Category: 87-41-2

87-41-2, Isobenzofuran-1(3H)-one is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Isobenzofuran-1(3H)-one (6.6 g, 49.6 mmol), NBS (9.7 g,54.5 mmol) and AIBN (0.8 g, 4.9 mmol) were diluted in dry carbon tetrachloride (CCl4) (200 mL) and heated to72C for 2.5h. The mixture was cooled to room temperatureovernight, filtered, and the residue was washed withpetroleum ether. The filtrate was concentrated in vacuo toprovide the crude product, which was recrystallized fromcyclohexane to give 2 (8.6 g, 81.8%) as a light brown solid;m. p. 79-82C (lit. [24]: 76-78C). – 1H NMR (600MHz,CDCl3): =7.65 (d, 1H, J=7.2Hz), 7.80-7.77 (m, 1H), 7.64-7.61(m, 2H), 7.41 (s, 1H). – 13C NMR (150MHz, CDCl3): =167.3,148.8, 135.2, 130.9, 125.9, 124.0, 123.5, 74.6.

87-41-2, 87-41-2 Isobenzofuran-1(3H)-one 6885, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Article; Fan, Lingling; Luo, Bilan; Luo, Zhongfu; Zhang, Li; Fan, Judi; Xue, Wei; Tang, Lei; Li, Yong; Zeitschrift fur Naturforschung, B: Chemical Sciences; (2019);,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.87-41-2,Isobenzofuran-1(3H)-one,as a common compound, the synthetic route is as follows.

6-Nitroisobenzofuran-1(3H)-one To a stirred solution of 3H-isobenzofuran-1-one (30.0 g, 0.220 mol) in H2SO4 (38 mL) was added KNO3 (28.0 g, 0.290 mol) in H2SO4 (60 mL) at 0 C. The mixture was stirred at 20 C. for 1 h. The reaction mixture was poured into ice and the resulting precipitate was filtered off. The solid was recrystallized from ethanol to give 6-nitroisobenzofuran-1(3H)-one (32.0 g, 80%). 1H NMR (300 MHz, CDCl3) delta 8.76 (d, J=2.1, 1H), 8.57 (dd, J=8.4, 2.1, 1H), 7.72 (d, J=8.4, 1H), 5.45 (s, 2H).

87-41-2, The synthetic route of 87-41-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Vertex Pharmaceuticals Incorporated; Van Goor, Fredrick F.; Burton, William Lawrence; US2015/231142; (2015); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

87-41-2, Isobenzofuran-1(3H)-one is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step (1) Preparation of 3-Bromophthalide A mixture of phthalide (7.5 g, 56 mmol) and N-bromosuccinimide (10 g, 55.5 mmol) in CCl4 (150 mL) was heated at reflux for 3 hours (reaction checked by TLC). The mixture was filtered hot and the filtrate was evaporated to dryness to yield the crude title compound (11.15 g, 97%). It was used as such in the next step.

87-41-2, As the paragraph descriping shows that 87-41-2 is playing an increasingly important role.

Reference£º
Patent; American Home Products Corporation; US4960902; (1990); A;,
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Benzofuran | C8H6O – PubChem

87-41-2, Isobenzofuran-1(3H)-one is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Isobenzofuran-1(3H)-one (0.4 mmol), KOH (0.4 mmol), PhSiH3 (1.2 mmol), dried THF (2 mL) were charged in a Schlenk tube(15 mL) under N2 atmosphere. The mixture was refluxed for 4 h. After cooling to rt, the reaction was quenched with EtOH(0.5-1 mL). Solvent was removed under reduced pressure and the crude residue was purified by column chromatography on silica gel with petroleum ether-ethyl acetate as the eluent to afford the desired product., 87-41-2

As the paragraph descriping shows that 87-41-2 is playing an increasingly important role.

Reference£º
Article; Liu, Bin; Zhou, Xigeng; Chinese Chemical Letters; vol. 30; 3; (2019); p. 725 – 728;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

87-41-2, Isobenzofuran-1(3H)-one is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of phthalide 1 (1 eq, 22 mmol, 3.0 g) in 30 mL ofH2SO4 (95e98%) was added dropwise at 0 C to a solution of KNO3(1.2 eq, 26.0 mmol, 2.63 g) in 12 mL of H2SO4 (95e98%). The reaction mixture was stirred at room temperature for 2h30 and then poured on ice. The resulting precipitate was filtered under reducedpressure and washed with distilled water. The filtrate was onceagain filtered under reduced pressure and the remaining solid waswashed with distilled water. The combined solids were dried under reduced pressure to give 6-nitroisobenzofuran-1(3H)-one 11(3.41 g, 87%) as an off-white solid; Rf (petroleum ether/ethyl acetate:70/30) 0.19; 1H NMR (300 MHz, CDCl3) d (ppm): 8.78 (d, J 2.1,0.7 Hz, 1H), 8.58 (dd, J 8.4, J 2.1 Hz, 1H), 7.72 (dd, J 8.4,J 0.7 Hz, 1H), 5.45 (s, 2H); HRMS (ESI): C8H5O4N [MNa],calculated 202.0111, found 202.0105. The spectral data was in accordance with the literature [24].

87-41-2, The synthetic route of 87-41-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Christine, Thifanie; Tabey, Alexis; Cornilleau, Thomas; Fouquet, Eric; Hermange, Philippe; Tetrahedron; vol. 75; 52; (2019);,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.87-41-2,Isobenzofuran-1(3H)-one,as a common compound, the synthetic route is as follows.

To a solution of phthalide (2.5 g, 18.65 mmol) in conc.H2S04 was added a solution of potassium nitrate (2.22 g, 18.65 mmol) in cone. H2S04. The reaction mixture was stirred at 0C for 30 minutes and quenched with water and filtered. The filtrate was concentrated and purified by column chromatography to afford 1.00 g of the title product. 1H NMR (300 MHz, DMSO-Je): delta 5.45 (s, 2H), 7.72 (d, / = 8.4 Hz, 1H), 8.58 (d, / = 8.1 Hz, 1H), 8.78 (s, 1H)., 87-41-2

As the paragraph descriping shows that 87-41-2 is playing an increasingly important role.

Reference£º
Patent; GLENMARK PHARMACEUTICALS S.A.; GHARAT, Laxmikant Atmaram; BANERJEE, Abhisek; KHAIRATKAR-JOSHI, Neelima; KATTIGE, Vidya Ganapati; WO2013/72825; (2013); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

87-41-2, Isobenzofuran-1(3H)-one is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

0.67 g (5 mmol, 1 equiv.) Of compound I are added at room temperature (2-Benzofuranone, Homemade, Journal of the American Chemical Society, 136 (49), 17180-17192; 2014) Add 15 mL of chloroform and 10mL acetic acid composition of the mixed solution, Stirring, Add under nitrogen protection N-bromobutanimide 1.067 g (6 mmol, 1.2 equiv.). Slow heating caused by reflux, After stirring for 5h, Dianban confirm the end of the reaction, The reaction liquid in the refrigerator for half an hour, Filter to remove the solid, Vacuum distillation, Washed, extraction, The organic phase was dried to give 1.06 g of crude product, which is, The mixture of compound IIa and compound IIb is to be directly cast into one reaction., 87-41-2

As the paragraph descriping shows that 87-41-2 is playing an increasingly important role.

Reference£º
Patent; Suzhou Haofan Biological Technology Co., Ltd.; Lv Minjie; Zhang Haiyan; Wang Guichun; Sun Fangchao; (9 pag.)CN105153013; (2017); B;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

87-41-2, Isobenzofuran-1(3H)-one is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

3H-Isobenzofuran-1-one (4.00 g, 29.8 mmol) was dissolved in concentrated sulfuric acid (5.0 ml) at 0 C., and a solution of potassium nitrate (3.0 g, 30 mmol) in concentrated sulfuric acid (8.0 ml) was added dropwise thereto. After stirring at room temperature for 5 hours, the reaction solution was diluted with water. The precipitated solid was filtered and recrystallized from ethanol (20 ml) to obtain the title compound (2.0 g, 37%). [1323] 1H NMR (400 MHz, DMSO-d6): delta 8.62-8.59 (m, 1H), 8.53 (d, J=2.8 Hz, 1H), 7.72 (d, J=8.0 Hz, 1H), 5.57 (s, 2H), 87-41-2

87-41-2 Isobenzofuran-1(3H)-one 6885, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; AJINOMOTO CO., LTD.; Ueno, Hirokazu; Yamamoto, Takashi; Takashita, Ryuta; Yokoyama, Ryohei; Sugiura, Toshihiko; Kageyama, Shunsuke; Ando, Ayatoshi; Eda, Hiroyuki; Eviryanti, Agung; Miyazawa, Tomoko; Kirihara, Aya; Tanabe, Itsuya; Nakamura, Tarou; Noguchi, Misato; Shuto, Manami; Sugiki, Masayuki; Dohi, Mizuki; US2015/51395; (2015); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem