Category: 87-41-2

An article Quinine-derived thiourea promoted enantioselective Michael addition reactions of 3-substituted phthalides to maleimides WOS:000467500500016 published article about ASYMMETRIC CONJUGATE ADDITION; CARBOXYLIC-ACIDS; FACILE ACCESS; QUATERNARY; DIHYDRONAPHTHOQUINONES; BENZOFURAN-2(3H)-ONES; BENZOFURAN-2-ONES; STEREOCENTERS; DERIVATIVES; CYCLIZATION in [Wang, Jie; Li, Xin; Cheng, Jin-Pei] Nankai Univ, State Key Lab Elementoorgan Chem, Collaborat Innovat Ctr Chem Sci & Engn, Coll Chem, Tianjin 300071, Peoples R China in 2019, Cited 44. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2. Application In Synthesis of Isobenzofuran-1(3H)-one

A highly diastereoselective and enantioselective Michael addition/desymmetrization reaction of maleimides with prochiral 3- substituted phthalides catalyzed by quinine-derived bifunctional thiourea was realized. A broad range of the 3,3-disubstituted phthalides bearing vicinal quaternary-tertiary stereogenic centers were synthesized in moderate to good yields (up to 96%) with high diastereoselectivities (up to >19:1 dr) and enantioselectivities (up to 96:4 er).

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Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Authors Feng, XY; Pi, YH; Song, Y; Xu, ZW; Li, Z; Lin, WB in AMER CHEMICAL SOC published article about in [Feng, Xuanyu; Pi, Yunhong; Song, Yang; Xu, Ziwan; Lin, Wenbin] Univ Chicago, Dept Chem, Chicago, IL 60637 USA; [Pi, Yunhong; Li, Zhong] South China Univ Technol, Sch Chem & Chem Engn, Guangzhou 510640, Peoples R China in 2021, Cited 63. Computed Properties of C8H6O2. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2

We report here the construction of two metal-organic frameworks (MOFs), Zr-6-Cu/Fe-1 and Zr-6–Cu/Fe-2, by integrating earth-abundant cuprous photosensitizers (Cu-PSs) and Fe catalysts for photocatalytic aerobic oxidation. Site isolation and pore confinement stabilize both Cu-PSs and Fe catalysts, while the proximity between active centers facilitates electron and mass transfer. Upon visible light irradiation and using O-2 as the only oxidant, Zr-6-Cu/Fe-1 and Zr-6-Cu/ Fe-2 efficiently oxidize alcohols and benzylic compounds to afford corresponding carbonyl products with broad substrate scopes, high turnover numbers of up to 500 with a 9.4-fold enhancement over homogeneous analogues, and excellent recyclability in four consecutive runs. Control experiments, spectroscopic evidence, and computational studies revealed the photooxidation mechanism: oxidative quenching of [Cu-PS]* by O-2 affords [Cu-II-PS], which efficiently oxidizes Fe-III-OH to generate a hydroxyl radical for substrate oxidation. This work highlights the potential of MOFs in promoting earth-abundant metal-based photocatalysis.

Welcome to talk about 87-41-2, If you have any questions, you can contact Feng, XY; Pi, YH; Song, Y; Xu, ZW; Li, Z; Lin, WB or send Email.. Computed Properties of C8H6O2

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Recommanded Product: Isobenzofuran-1(3H)-one. Hassan, AY; Mohamed, MA; Abdel-Aziem, A; Hussain, AO in [Hassan, A. Y.; Abdel-Aziem, A.; Hussain, A. O.] Al Azhar Univ, Chem Dept, Fac Sci, Girls Branch, POB 11754,Yousef Abbas Str, Cairo, Egypt; [Mohamed, M. A.] Al Azhar Univ, Girls Branch, Fac Sci, Biochem Div,Chem Dept, Cairo, Egypt published Synthesis and Anticancer Activity of Some Fused Heterocyclic Compounds Containing Pyrazole Ring in 2020, Cited 25. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2.

5-Amino-1-phenyl-1H-pyrazole-4-carbohydraizde(1) was used as a key to synthesize new imidazopyrazol-5(1H)-one 5, pyrazolopyrimidines 7 and 9. Furthermore, imidazopyrazoles 13, 15, pyrazolopyridine 16 and pyrazolopyrazolopyridopyrimidine 17 were prepared from pyrazoles 10 and 11. The structure of the new compounds was confirmed by spectral data as well as elemental analysis. Some compounds were selected by the national cancer institute NCI (USA) for anticancer activity against different human cancer cell lines. The results indicated that compound 12 exhibited strong anticancer activity toward Renal Cancer UO-31(GI, 42.81%), while compound 3 was strong active against Breast Cancer MCF7 (GI, 49.88%) and moderate against T-47D (GI, 38.15%) cell lines. However, compound 17 showed strong activity against Leukemia CCRF-CEM (GI, 41.37%) and SR (GI, 44.95%), whereas, compound 9 showed weak activity toward all tested cancer cell lines.

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Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Safety of Isobenzofuran-1(3H)-one. In 2021 ANGEW CHEM INT EDIT published article about ENANTIOSELECTIVE C-ACYLATION; SECONDARY ALCOHOLS; DERIVATIVES in [Zhou, Muxing; Zhang, Zhenfeng; He, Ende; Liu, Yangang; Zhang, Wanbin] Shanghai Jiao Tong Univ, Shanghai Key Lab Mol Engn Chiral Drugs, Sch Pharm, 800 Dongchuan Rd, Shanghai 200240, Peoples R China; [Gridneva, Tatiana; Zhang, Wanbin] Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, Frontiers Sci Ctr Transformat Mol, 800 Dongchuan Rd, Shanghai 200240, Peoples R China in 2021, Cited 47. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2.

Utilizing a chiral bicyclic imidazole organocatalyst and adopting a continuous injection process, an alternative route has been developed for the efficient synthesis of chiral phthalidyl ester prodrugs via dynamic kinetic resolution of 3-hydroxyphthalides through enantioselective acylation (up to 99 % ee). The computational studies suggest a general base catalytic mechanism differing from the widely accepted nucleophilic catalytic mechanism. The structure analysis of the key transition states shows that the CH-pi interactions and not the previously considered cation/pi-pi interactions between the catalyst and substrate is the dominant factor giving rise to the observed stereocontrol.

Safety of Isobenzofuran-1(3H)-one. Bye, fridends, I hope you can learn more about C8H6O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Recommanded Product: 87-41-2. I found the field of Chemistry very interesting. Saw the article EXPLORATION OF MODERATE CONDITIONS AND SUBSTRATE VARIATION IN THE DIRECT CONDENSATION BETWEEN PHTHALIDE AND PRIMARY AMINE CATALYZED BY GaCl3. ARE ALIPHATIC AMINES LESS REACTIVE THAN AROMATIC ONES? published in 2019, Reprint Addresses Takahashi, I (corresponding author), Univ Fukui, Fac Engn, Dept Appl Chem & Biotechnol, Bunkyo Ku, Fukui 9108507, Japan.. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one.

Direct condensation between phthalide and a primary amine in the presence of Lewis acid was achieved for the first time in organic solvent-diluted reaction systems catalyzed by GaCl3. The peripheral aspects of this reaction is discussed.

Welcome to talk about 87-41-2, If you have any questions, you can contact Takahashi, I; Nishiwaki, Y; Saitoh, K; Matsunaga, T; Aratake, A; Morita, T; Hosoi, S or send Email.. Recommanded Product: 87-41-2

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

An article Synthesis of Poly(Arylene Alkenylene)s by Pd-Catalyzed Three-Component Coupling Polycondensation of Diiodoarenes, Non-Conjugated Dienes, and Nucleophiles that Involves Chain Walking Isomerization WOS:000490302000001 published article about ALLYLIC AMINES; ARYL IODIDES; POLYMERIZATION; POLYMERS; COMPLEX; ETHYLENE; CYCLOPOLYMERIZATION; COPOLYMERIZATION; POLYETHYLENES; ALKYLENE)S in [Tan, Liyi; Takeuchi, Daisuke; Osakada, Kohtaro] Tokyo Inst Technol, Lab Chem & Life Sci, R1-03,4259 Nagatsuta, Yokohama, Kanagawa 2268503, Japan; [Takeuchi, Daisuke] Hirosaki Univ, Grad Sch Sci & Technol, Dept Frontier Mat Chem, 3 Bunkyo Cho, Hirosaki, Aomori 0368561, Japan in , Cited 41. Application In Synthesis of Isobenzofuran-1(3H)-one. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2

The Pd-catalyzed three-component coupling polycondensation of diiodoarenes, nonconjugated dienes, and carbonucleophiles afforded poly(arylene alkenylene)s with moderate molecular weight in good yield. The reaction involves Mizoroki-Heck coupling, olefin migration via chain walking, and addition of the carbonucleophile to the resulting pi-allylpalladium species. The polymerization with a slight excess of nucleophile with respect to diiodoarene also proceeded to give the polymer without significant decrease in molecular weight in spite of the nonstoichiometric mixture of the monomers. The Pd-catalyzed three-component coupling polycondensation of diiodoarenes, nonconjugated dienes, and diimide also proceeded. The base used in the reaction is critical for yield and molecular weight of the product. The reaction using NaHCO3 afforded the product with low solubility, which can be explained by the high molecular weight of the polymer and/or the strong interaction of the electron donating dimethoxyphenylene groups and electron accepting diimide groups in the polymer. (c) 2019 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2019

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Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

In 2019 MOLECULES published article about ONE-STEP SYNTHESIS; BENZOIC-ACIDS; CARBOXYLIC-ACIDS; SOFT ACIDS; OXIDASE CATALYSIS; INTERNAL ALKYNES; H ALKENYLATIONS; BASES HSAB; ALDEHYDES; KETONES in [Renzetti, Andrea; Fukumoto, Kozo] Univ Ryukyus, Fac Educ, 1 Senbaru, Nishihara, Okinawa 9030213, Japan in 2019, Cited 68. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2. Recommanded Product: 87-41-2

Phthalides and ,-butenolides are two related classes of oxygenated heterocycles with a wide range of biological activities. An innovative strategy to prepare these compounds is based on CH bond functionalization reactions, in which two simple, unfunctionalized molecules are coupled together with cleavage of a CH bond and formation of a CX bond (X=C or heteroatom). This paper reviews the methods for the synthesis of phthalides and ,-butenolides by CH bond functionalization from non-halogenated starting materials. Over 30 methods are reported, mostly developed during the past ten years.

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Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

COA of Formula: C8H6O2. I found the field of Environmental Sciences & Ecology; Toxicology very interesting. Saw the article Investigation of the Potential Environmental Risks of Phthalate Derivatives Designed To Be Environmentally Friendly published in 2020, Reprint Addresses Li, Y (corresponding author), North China Elect Power Univ, Coll Environm Sci & Engn, Beijing, Peoples R China.; Li, Y (corresponding author), North China Elect Power Univ, State Key Lab Reg Optimizat Energy Syst, Beijing, Peoples R China.. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one.

Phthalate derivatives with low estrogenic activity, high infrared spectrum signals, high Raman characteristic vibration spectrum, high fluorescence intensity, and high ultraviolet sensitivity were selected as precursors from our previous studies, so that the changes in their toxicity and estrogenic activity during biological metabolism, ozone oxidation, photocatalytic degradation, photodegradation, and microbial degradation could be studied.The transformation pathways of these derivatives were simulated, and the reaction energy barriers were calculated. To determine the potential environmental risks of these phthalate derivatives, the pharmacophore models of biotoxicity and estrogen activity of phthalates were used to predict the biotoxicity and estrogen activity of the transformed products. The results showed an increase in the biotoxicity and estrogen activity of the biometabolites, ozonation products, photocatalytic degradation products, and microbial degradation products; the only products that did not follow this trend were the photodegradation products. Notably, the pathways that produced more potentially toxic compounds were the less favorable paths. Our results indicate that the transformation products of the designed environmentally friendly phthalate derivatives potentially pose environmental risks. To avoid such risks, the environmental transformation pathway of these derivatives should be simulated to screen for environmentally friendly phthalate molecules. Environ Toxicol Chem 2020;00:1-11. (c) 2020 SETAC

COA of Formula: C8H6O2. Bye, fridends, I hope you can learn more about C8H6O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Safety of Isobenzofuran-1(3H)-one. In 2020 J MED CHEM published article about PROTEASE INHIBITORS; PHARMACOKINETICS; GLECAPREVIR; NUCLEOSIDE; DESIGN; SAFETY; SINGLE in [Randolph, John T.; Voight, Eric A.; Greszler, Stephen N.; Uno, Brice E.; Newton, James N.; Gleason, Kenneth M.; Stolarik, DeAnne; Van Handel, Cecilia; Bow, Daniel A. J.; DeGoey, David A.] Abbvie Inc, Global Pharmaceut Res & Dev, N Chicago, IL 60064 USA in 2020, Cited 26. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2.

A research program to discover solubilizing prodrugs of the HCV NS5A inhibitor pibrentasvir (PIB) identified phosphomethyl analog 2 and trimethyl-lock (TML) prodrug 9. The prodrug moiety is attached to a benzimidazole nitrogen atom via an oxymethyl linkage to allow for rapid and complete release of the drug for absorption following phosphate removal by intestinal alkaline phosphatase. These prodrugs have good hydrolytic stability properties and improved solubility compared to PIB, both in aqueous buffer (pH 7) and FESSIF (pH 5). TML prodrug 9 provided superior in vivo performance, delivering high plasma concentrations of PIB in PK studies conducted in mice, dogs, and monkeys. The improved dissolution properties of these phosphate prodrugs provide them the potential to simplify drug dosage forms for PIB-containing HCV therapy.

Safety of Isobenzofuran-1(3H)-one. Welcome to talk about 87-41-2, If you have any questions, you can contact Randolph, JT; Voight, EA; Greszler, SN; Uno, BE; Newton, JN; Gleason, KM; Stolarik, D; Van Handel, C; Bow, DAJ; DeGoey, DA or send Email.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

I found the field of Engineering very interesting. Saw the article Photocatalytic degradation of gaseous VOCs over Tm3+-TiO2: Revealing the activity enhancement mechanism and different reaction paths published in 2020. Quality Control of Isobenzofuran-1(3H)-one, Reprint Addresses Xie, XF; Sun, J (corresponding author), Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, 1295 Dingxi Rd, Shanghai 200050, Peoples R China.. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one

In this work, we synthesized thulium (Tm3+) modified TiO2 nanoparticles by a facile sol-gel route. We show that Tm3+-modified TiO2 exhibit superior photocatalytic activity than pure TiO2 towards gas-phase degradation of acetaldehyde, o-xylene, and their mixture. The photocatalytic activity enhances with the increasing Tm content from 0.1 to 0.5 mol%. The 0.5 mol%Tm-TiO2 sample demonstrated the highest photodegradation efficiency (> 90.0%) for acetaldehyde and o-xylene. According to the systematic characterization such as photoluminescence (PL), photocurrent, up-conversion spectra, UV-Vis diffuse reflectance spectroscopy and electron spin resonance (ESR) analysis, the enhanced photocatalytic performance can be attributed to introducing the new Tm-4f states between the original band gap of TiO2, which led to the increase of efficiency of light-induced electron-hole separation and the increase of hydrophilicity which resulted in the increased adsorption capacity towards acetaldehyde and o-xylene. Gas Chromatography-Mass Spectrometer (GC-MS) analysis suggested that o-xylene was first oxidized to o-benzaldehyde, which was eventually converted to butanol before being mineralized into CO2. However, new intermediates including phthalide, o-methyl acetophenone, naphthalene and 5-Methyl-4-octanone were detected in the mixture.

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Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem