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Heterocyclic thromboxane synthetase inhibitors of the formula STR1 wherein R1, which is attached to the 2-, 3- or 4-position, is hydrogen, halogen, C1 -C4 alkyl, hydroxy or C1 -C4 alkoxy; Y, which is attached to the 2- or 3-position, is –COOH, –COO(C1 -C4 alkyl) or –CONH2 ; X is O, S, NH, N(C1 -C4 alkyl) or N(benzyl); and R, which is attached to the 5-, 6- or 7-position, is a group of the formula STR2 or (3- or 4-pyridyl)-Z2 – wherein Z1 is –CH2 –, –CH2 CH2 — or –CH2 CH2 O– and Z2 is –CH2 –, –CH2 CH2 –, –CH=CH–, –CH2 O– or –OCH2 –; and their pharmaceutically acceptable salts; processes for their preparation, and pharmaceutical compositions containing them.

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Benzofuran – Wikipedia,
Benzofuran | C8H3062O – PubChem

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The present invention provides a compound of formula (I), in which R1, R2 and R3 are defined in the Summary of the Invention, or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses linked to hERG activation. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H3061O – PubChem

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POLYCYCLIC HERG ACTIVATORS

The present invention provides a compound of formula I, in which R1, R2, X and R3 are defined in the Summary of the Invention, or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

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Benzofuran – Wikipedia,
Benzofuran | C8H3060O – PubChem

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2-Nitrofurans as dienophiles in Diels-Alder reactions

alpha-Nitrofuran derivatives are studied in Diels-Alder reactions under thermal conditions. In contrast to alpha-acylfurans, they proved to be efficient dienophiles.

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Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H3063O – PubChem