Category: 67713-99-9

Application of 67713-99-9, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 67713-99-9, Name is 3-(Chloromethyl)benzofuran, molecular formula is C9H7ClO. In a Article，once mentioned of 67713-99-9

Discovering dopamine D2-like receptor subtype-selective ligands has been a focus of significant investigation. The D2R-selective antagonist 3-[4-(4-chlorophenyl)-4-hydroxypiperidinyl]methylindole (1, L741,626; K i(D2R/D3R) = 11.2:163 nM) has previously provided a lead template for chemical modification. Herein, analogues have been synthesized where the piperidine was replaced by a tropane ring that reversed the selectivity seen in the parent compound, in human hD2LR- or hD3R-transfected HEK 293 cells (31, Ki(D2R/D3R) = 33.4: 15.5 nM). Further exploration of both N-substituted and aryl ring-substituted analogues resulted in the discovery of several high affinity D2R/D3R ligands with 3-benzofurylmethyl-substituents (e.g., 45, Ki(D2R/D3R) = 1.7:0.34 nM) that induced high affinity not achieved in similarly N-substituted piperidine analogues and significantly (470-fold) improved D3R binding affinity compared to the parent ligand 1. X-ray crystallographic data revealed a distinctive spatial arrangement of pharmacophoric elements in the piperidinol vs tropine analogues, providing clues for the diversity in SAR at the D2 and D3 receptor subtypes.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Application of 67713-99-9. In my other articles, you can also check out more blogs about 67713-99-9

Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H2583O – PubChem

Chemistry is traditionally divided into organic and inorganic chemistry. Computed Properties of C9H7ClO, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent，Which mentioned a new discovery about 67713-99-9

Four series of phenylpiperazinylmethylimidazo[1,2-a]pyridine, phenylpiperazinyl-methylpyrrole, phenylpiperazinylmethylbenzofuran, and phenylpiperazinylme-thylbenzothiophene derivatives were synthesized and investigated for their in vitro binding profiles for the dopamine receptor subtypes D1, D2long, D2Short D3 and D4. All tested compounds showed selectivity towards the D4 receptor subtype. Affinity and selectivity for D4 follows the order imidazo[1,2-a]pyridine > benzofuran > benzothiophene > pyrrole derivatives. The D4-related affinity and selectivity pattern seems to be dependent on the presence of a region of negative molecular electrostatic potential below the heterocyclic moiety.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H2575O – PubChem

Synthetic Route of 67713-99-9, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.67713-99-9, Name is 3-(Chloromethyl)benzofuran, molecular formula is C9H7ClO. In a article，once mentioned of 67713-99-9

Provided herein are compounds, such as a compound of Formula (I), or a pharmaceutically acceptable salt thereof, that are immunoproteasome (such as LMP2 and LMP7) inhibitors. The compounds described herein can be useful for the treatment of diseases treatable by inhibition of immunoproteasomes. Also provided herein are pharmaceutical compositions containing such compounds and processes for preparing such compounds.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 67713-99-9

Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H2574O – PubChem

Reference of 67713-99-9, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 67713-99-9, Name is 3-(Chloromethyl)benzofuran,introducing its new discovery.

The first asymmetric dearomatization addition reaction of halomethyl arenes including benzofuran and benzothiophene was enabled by chromium catalysis. A variety of aldehydes served as suitable electrophiles under mild reaction conditions. Molecular complexities are quickly increased in a highly diastereo- and enantioselective manner.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H2585O – PubChem

Electric Literature of 67713-99-9, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 67713-99-9, Name is 3-(Chloromethyl)benzofuran,introducing its new discovery.

Acrylic acids and alanines substituted with heteroaryl groups at the beta-position were synthesized and spectroscopically characterized (UV, HRMS, 1H NMR, and 13C NMR spectroscopy). The heteroaryl groups were furanyl, thiophenyl, benzofuranyl, and benzothiophenyl and contained the alanyl side chains either at the 2- or 3-positions. While the former are good substrates for phenylalanine ammonia lyase (PAL), the latter compounds are inhibitors. Exceptions are thiophen-3-yl-alanine, a moderate substrate and furan-3-yl-alanine, which is inert. Possible reasons for these exceptions are discussed. Starting from racemic het eroaryl-2-alanines their D-enantiomers were prepared by using a stereodestructive procedure. From the heteroaryl-2- acrylates, the L-enantiomers of the heteroaryl-2-alanines were prepared at high ammonia concentration. These results can be best explained by a Friedel – Crafts-type electrophilic attack at the aromatic part of the substrates as the initial step of the PAL reaction.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H2582O – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Safety of 3-(Chloromethyl)benzofuran, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 67713-99-9, Name is 3-(Chloromethyl)benzofuran, molecular formula is C9H7ClO

Various diethyl 3-arylisoxazole-4,5-dicarboxylates were efficiently prepared in good to moderate yields by the successive treatment of benzylic chlorides and alkyl p-tosylates with N-methylmorpholine N-oxide (NMO) and then hydroxylamine hydrochloride and potassium carbonate followed by Oxone and diethyl acetylenedicarboxylates. This one-pot proccess was carried out under mild, transition-metal-free conditions.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H2578O – PubChem

Application of 67713-99-9, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.67713-99-9, Name is 3-(Chloromethyl)benzofuran, molecular formula is C9H7ClO. In a Article，once mentioned of 67713-99-9

Novel, potent non-imidazole histamine H3 receptor antagonists have been prepared and in vitro tested as H3-receptor antagonists (the electrically evoked contraction of the guinea-pig jejunum). The present compounds contain a 4-hydroxypiperidine core, which behaves as a conformationally restricted version of the 3-amino-1-propanol moiety common to the many previously described non-imidazole H3 ligands. Detailed structure-activity studies revealed that 1-(2-benzofuranylmethyl)- 5c (pA 2 = 8.47 ± 0.05) and 1-(3-benzofuranylmethyl)-4-[5-(N-methyl- N-propyl)pentyloxy]piperidine 5d (pA2 = 8.15 ± 0.07) exhibit high potency for the H3 histamine receptor. In addition, the potency of selected 1-[(N-substituted-N-methyl)-3-propyloxy]-5-(N-methyl-N-propyl) pentanediamines as antagonist of the H3 histamine receptor was also evaluated. Replacement of the 4-hydroxypiperidine of the leads 7 and 5c by a highly flexible 3-(methylamino)propyloxy chain yields compounds 6a (pA 2 = 8.02) and 6b (pA2 = 6.23) with higher and lower potency than their piperidine analogues (7, pA2 = 7.79; 5c, pA 2 = 8.47), respectively. The histaminergic H1 antagonism of selected compounds 5c, 5d and 6a has been established on the isolated guinea-pig ileum by conventional methods; the pA2 values have compared with the potency of pyrilamine. None of them showed any H 1-antagonistic activity (pA2 < 4; for pyrilamine pA2 = 8.5). The present compounds contain a 4-hydroxypiperidine core, which behaves as a conformationally restricted version of the 3-amino-1-propanol moiety common to the many previously described non-imidazole H3 ligands. Detailed structure-activity studies revealed that 1-(2-benzofuranylmethyl)- 5c (pA2 = 8.47 ± 0.05) and 1-(3-benzofuranylmethyl)-4-[5-(N-methyl-N-propyl)pentyloxy]piperidine 5d (pA2 = 8.15 ± 0.07) exhibit high potency for the H3 histamine receptor. Replacement of the 4-hydroxypiperidine of the leads 7 and 5c by a highly flexible 3-(methylamino)propyloxy chain yields compounds 6a (pA2 = 8.02) and 6b (pA2 = 6.23) with higher and lower potency than their piperidine analogues (7, pA2 = 7.79; 5c, pA 2 = 8.47), respectively. A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 67713-99-9 Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H2581O – PubChem