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Disclosed herein is a new class of pyrazole compounds which act at the 5HT2A receptors.

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Benzofuran – Wikipedia,
Benzofuran | C8H3327O – PubChem

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The transient receptor potential ankyrin 1 (TRPA1) channel is activated by a series of by-products of oxidative/nitrative stress, produced under inflammatory conditions or in the case of tissue damage, thus generating inflammatory and neuropathic pain and neurogenic inflammatory responses. These findings have identified TRPA1 as an emerging opportunity for the design and synthesis of selective inhibitors as potential analgesic and antiinflammatory agents. Herein we present the synthesis and functional evaluation of a new series of 7-substituted-1,3-dimethyl-1,5-dihydro-pyrrolo[3,2-d]pyrimidine-2,4- dione derivatives designed as TRPA1 antagonists. A small library of compounds has been built by the introduction of differently substituted N 7-phenylacetamide or N7-[4-(substituted-phenyl)-thiazol-2- yl]-acetamide chains. All the synthesized compounds were assayed to evaluate their ability to block acrolein-mediated activation of native human and rat TRPA1 channels employing a fluorometric calcium imaging assay. Our study led us to the identification of compound 3h which showed considerably improved potency (IC50 = 400 nM) against human TRPA1 with regard to some of the most representative antagonists previously reported and integrated in our screening program as reference compounds. In addition, 3h proved to maintain its efficacy toward rTRPA1, which designates it as a possible candidate for future evaluation of in vivo efficacy in rodent animal model of inflammatory and neuropathic pain.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H3355O – PubChem

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This invention is directed to compounds and salts that are generally useful as anthelmintic agents or as intermediates in processes for making anthelmintic agents. This invention also is directed to processes for making the compounds and salts, pharmaceutical compositions and kits comprising the compounds and salts, uses of the compounds and salts to make medicaments, and treatments comprising the administration ofthe compounds and salts to animals in need of the treatments.

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Benzofuran – Wikipedia,
Benzofuran | C8H3328O – PubChem

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PROBLEM TO BE SOLVED: bakanae noxious organism pest control composition having excellent. SOLUTION: eq. (1) and indicated by a condensed heterocyclic compound, selected from a group of one or more A-D agrochemically active component 1 and persticide compsn. contg.. Group A; a sterilizing agent, group B; insecticide Nematicide · · acaricide, group C; reducting agent, group D; plant growth regulator (R 1 is H, 1 containing one or more halogen atom is substituted for/unsubstd. C1-C3 alkyl group, a halogen atom, C1-C3 alkoxy group, an alkoxy carbonyl group C2-C4, S (O) m R 2, NR 3 R 4, or nitro group, a cyano group; R 2 the alkyl group C1-C3; R 3 and R 4 are each independently H or C1-C3 alkyl group; R 5 the CF 3, C 2 F 5 or S (O) p CF 3; X the CH or N; the Y NH, NCH 3, O or S; m, n and p are each independently an integer) selected drawing 0-2:no (by machine translation)

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H3346O – PubChem

Final Thoughts on Chemistry for 5-Bromo-2,3-dihydrobenzofuran

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Fluorescent deep-blue emitters consisting of arylamine chrysene have attracted immense commercial interest in organic light-emitting devices (OLEDs). Herein, we endeavor to design emitters with super hydrophobic groups, namely trifluoromethoxy ([sbnd]OCF3) or trifluoromethylsufanyl ([sbnd]SCF3) substituted on 6,12-diarylamine chrysene. Surprisingly, the new materials show highly efficient and substantial blue shift in fluorescence spectra with more pure color quality, higher thermostability and better moisture resistant properties. Astonishing electroluminescence performance is envisioned by promoting the molecular design based on experience and theoretical calculations along with the single crystal X-Ray analysis. The CIE coordinate values for 6, 12-diamine-N,N,N?,N?-tetra(p-trifluoromethoxyphenyl)chrysene (DATPC-OCF3) and 6,12-diamine-N,N,N?,N?-tetra(p-trifluoromethylsulfanylphenyl)chrysene (DATPC-SCF3) are (0.14, 0.09) and (0.15, 0.06), respectively, which exactly match with the National Television System Committee (NTSC) and High-Definition Television requirements for unprecedented deep-blue emission.

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Benzofuran – Wikipedia,
Benzofuran | C8H3370O – PubChem

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A quinazoline derivative, its synthesis is simple, raw material sources are extensive. It adopts the quinazoline skeleton, through the introduction of the fluorine-containing group – CF kuikui zuo lin link2 H? – SCF3 , To obtain a series of with anti-tumor activity of the quinazoline derivatives, these compounds compared with erlotinib, demonstrates better activity, and less toxicity. A quinazoline derivative of the preparation method, by means of a simple substitution reaction can be obtained with high efficiency and high quality of the quinazoline derivatives, simple and convenient operation, high requirements on equipment, is suitable for use with large-scale production. An above-mentioned quinazoline derivatives, the quinazoline derivative can be applied to the production of anti-tumor drug, compared with the prior of for erlotinib, it can achieve a better curative effect and smaller toxic side effects. (by machine translation)

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H3340O – PubChem

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The invention relates to a sulfonamide compound of formula (I) or a pharmaceutically, veterinarily or agriculturally acceptable salt or solvate thereof, where the groups R1-R5 are described in the description, to compositions comprising such compounds, processes for their synthesis and their use as parasiticides.

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Benzofuran – Wikipedia,
Benzofuran | C8H3330O – PubChem

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2-Amino-benzo[d]thiazole was identified as a new scaffold for the development of improved pteridine reductase-1 (PTR1) inhibitors and anti-trypanosomatidic agents. Molecular docking and crystallography guided the design and synthesis of 42 new benzothiazoles. The compounds were assessed for Trypanosoma brucei and Leishmania major PTR1 inhibition and in vitro activity against T. brucei and amastigote Leishmania infantum. We identified several 2-amino-benzo[d]thiazoles with improved enzymatic activity (TbPTR1 IC50 = 0.35 muM; LmPTR1 IC50 = 1.9 muM) and low muM antiparasitic activity against T. brucei. The ten most active compounds against TbPTR1 were able to potentiate the antiparasitic activity of methotrexate when evaluated in combination against T. brucei, with a potentiating index between 1.2 and 2.7. The compound library was profiled for early ADME toxicity, and 2-amino-N-benzylbenzo[d]thiazole-6-carboxamide (4c) was finally identified as a novel potent, safe, and selective anti-trypanocydal agent (EC50 = 7.0 muM). Formulation of 4c with hydroxypropyl-beta-cyclodextrin yielded good oral bioavailability, encouraging progression to in vivo studies.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H3372O – PubChem

Extracurricular laboratory:new discovery of 5-Bromo-2,3-dihydrobenzofuran

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A simple two-step synthesis method was used to make 51 B-ring-substituted 4-hydroxyquinolines allowing analysis of the effect of ring substitutions on inhibition of growth of chloroquine sensitive and resistant strains of Plasmodium falciparum, the dominant cause of malaria morbidity. Substituted quinoline rings other than the 7-chloroquinoline ring found in chloroquine were found to have significant activity against the drug-resistant strain of P. falciparum W2.

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Benzofuran – Wikipedia,
Benzofuran | C8H3374O – PubChem

The important role of 5-Bromo-2,3-dihydrobenzofuran

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Syntheses are reported for 2,3,3-trimethyl-3H-indoles and 1,1,2-trimethyl-1H-benzindoles with fluorine-containing substituents (CF3, SCF3, and SO2CF3) at C-5 and for carbocyanine, merocyanine, and styryl dye derivatives of these indoles.The fluorine-containing substituents studied produce a bathochromic effect in the styryl dyes, hypsochromic effect in the merocyanine dyes, and, as a rule, a hypsochromic effect in the carbocyanine dyes.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H3380O – PubChem