One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, COA of Formula: C8H7BrO, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 66826-78-6, Name is 5-Bromo-2,3-dihydrobenzofuran, molecular formula is C8H7BrO
The transient receptor potential ankyrin 1 (TRPA1) channel is activated by a series of by-products of oxidative/nitrative stress, produced under inflammatory conditions or in the case of tissue damage, thus generating inflammatory and neuropathic pain and neurogenic inflammatory responses. These findings have identified TRPA1 as an emerging opportunity for the design and synthesis of selective inhibitors as potential analgesic and antiinflammatory agents. Herein we present the synthesis and functional evaluation of a new series of 7-substituted-1,3-dimethyl-1,5-dihydro-pyrrolo[3,2-d]pyrimidine-2,4- dione derivatives designed as TRPA1 antagonists. A small library of compounds has been built by the introduction of differently substituted N 7-phenylacetamide or N7-[4-(substituted-phenyl)-thiazol-2- yl]-acetamide chains. All the synthesized compounds were assayed to evaluate their ability to block acrolein-mediated activation of native human and rat TRPA1 channels employing a fluorometric calcium imaging assay. Our study led us to the identification of compound 3h which showed considerably improved potency (IC50 = 400 nM) against human TRPA1 with regard to some of the most representative antagonists previously reported and integrated in our screening program as reference compounds. In addition, 3h proved to maintain its efficacy toward rTRPA1, which designates it as a possible candidate for future evaluation of in vivo efficacy in rodent animal model of inflammatory and neuropathic pain.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. COA of Formula: C8H7BrO, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 66826-78-6, in my other articles.
Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H3355O – PubChem