Category: 6296-53-3

Chemistry is traditionally divided into organic and inorganic chemistry. Product Details of 6296-53-3, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent，Which mentioned a new discovery about 6296-53-3

The present invention relates to a process for providing a chiral beta-hydroxysulfone compound, an intermediate useful in the synthesis of the isoindoline-based compound apremilast.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H3467O – PubChem

Chemistry is traditionally divided into organic and inorganic chemistry. HPLC of Formula: C10H7NO4, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent，Which mentioned a new discovery about 6296-53-3

The present invention relates to a process for preparation of apremilast. The present invention relates to p-xylene solvate of apremilast and process for its preparation.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H3421O – PubChem

Reference of 6296-53-3, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Patent, and a compound is mentioned, 6296-53-3, N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide, introducing its new discovery.

The present invention provides an improved process for preparation of pure N-(2-(l-(3- ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-l,3-dioxoisoindolin-4-yl)acetamide (1) (commonly known as Apremilast); wherein the content of des-acetyl apremilast (la) is less than 1% w/w and having total amount of genotoxic substances less than 25 ppm; comprising the steps of reacting the compound l-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethan- 1-amine (A) or its chiral acid salt with N-(l,3-dioxo-l,3-dihydroisobenzofuran-4-yl)-acetamide (B) in presence of ether or amide solvent and optionally, in presence of an acid; followed by the treatment with an acetylating agent.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Reference of 6296-53-3. In my other articles, you can also check out more blogs about 6296-53-3

Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H3437O – PubChem

Reference of 6296-53-3, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.6296-53-3, Name is N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide, molecular formula is C10H7NO4. In a Patent，once mentioned of 6296-53-3

Disclosed are a novel isoindoline derivative, a pharmaceutical composition and use thereof. The compound of formula I, or the pharmaceutically acceptable salt, solvate, polymorph, co-crystal, stereoisomer, isotopic compound, metabolite or prodrug thereof disclosed in the invention can regulate the generation and/or activity of PDE4 and/or TNF-alpha so as to effectively treat cancer and inflammatory diseases.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 6296-53-3

Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H3443O – PubChem

Application of 6296-53-3, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Patent, and a compound is mentioned, 6296-53-3, N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide, introducing its new discovery.

Present application relates to the process for the preparation of 1-(3-Ethoxy-4-methoxy-phenyl)-2-methanesulfonyl-ethylamine of the formula (II), its resolution and its use in preparation of Apremilast of formula (I), process for the preparation of crystalline form B of apremilast, process for preparation of amorphous form of apremilast and the crystalline form of (S)-1-(3-Ethoxy-4-methoxy-phenyl)-2-methanesulfonyl-ethylamine of the formula (Va).

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Application of 6296-53-3. In my other articles, you can also check out more blogs about 6296-53-3

Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H3473O – PubChem

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Formula: C10H7NO4, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 6296-53-3, name is N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide. In an article，Which mentioned a new discovery about 6296-53-3

The present invention relates to new substituted isoindoline -1,3-dione derivatives and their pharmaceutically acceptable salts. More specifically, the invention relates to novel substituted analogue apremilast isoindoline -1,3-dione derivatives. The invention also provides a compound of the invention composition and the carrier, and the compounds and compositions disclosed by administering cryptoequipment apremilast the treatment treating diseases and use of the method of the state. (by machine translation)

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H3448O – PubChem

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. SDS of cas: 6296-53-3, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 6296-53-3, name is N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide. In an article，Which mentioned a new discovery about 6296-53-3

no abstract published

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H3440O – PubChem

Synthetic Route of 6296-53-3, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, and a compound is mentioned, 6296-53-3, N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide, introducing its new discovery.

In this communication, we report the discovery of 1S (apremilast), a novel potent and orally active phosphodiesterase 4 (PDE4) and tumor necrosis factor-alpha inhibitor. The optimization of previously reported 3-(1,3-dioxo-1,3-dihydroisoindol-2-yl)-3-(3,4-dimethoxyphenyl)propionic acid PDE4 inhibitors led to this series of sulfone analogues. Evaluation of the structure-activity relationship of substitutions on the phthalimide group led to the discovery of an acetylamino analogue 1S, which is currently in clinical trials.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Synthetic Route of 6296-53-3. In my other articles, you can also check out more blogs about 6296-53-3

Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H3485O – PubChem

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Recommanded Product: N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 6296-53-3, name is N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide. In an article，Which mentioned a new discovery about 6296-53-3

The present invention provides a method for preparing apps is special and intermediates thereof. The present invention provides a kind of type III intermediates apps is special shown, and the compound of the formula III are sequentially and methyl sulfonate reaction, reductive amination, and the asymmetric acid salt forming, and 3-acetyl amino group is obtained by reacting phthalic anhydride apps is special. The present invention provides synthetic apps is special method can avoid the use of n-butyl lithium-hexane solution, not only reduce the production cost, and has the advantage of convenient operation process, and a large extent in improving the safety of the industrial production, and more suitable commercial continuous production. Of this invention offers 3-acetamino method for preparing phthalic anhydride to improve the yield of 81%, higher yield, is extremely suitable for industrial production of apps is special. (by machine translation)

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H3475O – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, HPLC of Formula: C10H7NO4, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 6296-53-3, Name is N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide, molecular formula is C10H7NO4

The invention relates to a 3-acetamide group ortho-phthalic acid imide preparation method, including: the 3-nitrophthalic acid is dissolved in sodium hydroxide aqueous solution, then adding reducing agent and catalyst, heating to 70-80C, stirring reaction 1-20 hours, recrystallization, to obtain 3-amino-O-phthalic acid; stirring reflux reaction with acetic anhydride 1-10 hours, to obtain 3-acetamide group of phthalic anhydride; the 3-acetamide group of phthalic anhydride dissolved in organic solvent, by adding amino donor, stirring reflux 1-10 hours, to obtain 3-acetamide group ortho-phthalic acid imide. The method of the present invention the operation is simple, high yield, the reaction route is short, the three wastes are few, easy commercial production. (by machine translation)

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. HPLC of Formula: C10H7NO4, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 6296-53-3, in my other articles.

Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H3479O – PubChem