Category: 6296-53-3

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. SDS of cas: 6296-53-3. Introducing a new discovery about 6296-53-3, Name is N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide

Nonsense mutations introduce premature termination codons and underlie 11% of genetic disease cases. High concentrations of aminoglycosides can restore gene function by eliciting premature termination codon readthrough but with low efficiency. Using a high-throughput screen, we identified compounds that potentiate readthrough by aminoglycosides at multiple nonsense alleles in yeast. Chemical optimization generated phthalimide derivative CDX5-1 with activity in human cells. Alone, CDX5-1 did not induce readthrough or increase TP53 mRNA levels in HDQ-P1 cancer cells with a homozygous TP53 nonsense mutation. However, in combination with aminoglycoside G418, it enhanced readthrough up to 180-fold over G418 alone. The combination also increased readthrough at all three nonsense codons in cancer cells with other TP53 nonsense mutations, as well as in cells from rare genetic disease patients with nonsense mutations in the CLN2, SMARCAL1 and DMD genes. These findings open up the possibility of treating patients across a spectrum of genetic diseases caused by nonsense mutations.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.SDS of cas: 6296-53-3, you can also check out more blogs about6296-53-3

Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H3482O – PubChem

Related Products of 6296-53-3, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 6296-53-3, Name is N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide, molecular formula is C10H7NO4. In a Patent，once mentioned of 6296-53-3

The invention provides a synthetic method for 3 – preparing erprista by taking a raw S – 1 – (3 – material as a raw) – 2 – material as a N – raw material by taking a raw material as a raw material as a raw material. The method has the advantages of simple operation, high yield, small pollution, suitability for large quantity of preparation and the like. (by machine translation)

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Related Products of 6296-53-3. In my other articles, you can also check out more blogs about 6296-53-3

Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H3474O – PubChem

6296-53-3, Name is N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide, belongs to benzofurans compound, is a common compound. Product Details of 6296-53-3In an article, once mentioned the new application about 6296-53-3.

The invention discloses a process for preparing high-purity app Si Te (type I) method of industrialization of intermediates thereof. The method is to 3-nitrophthalic acid (compound II) as the starting material, with organic acid or an acid anhydride as a solvent, the different intermediates of preparing high-purity 3-acetyl-phthalic anhydride (compound IV), directly without drying the product in glacial acetic acid in the reflux (S) – 1 – (3-ethoxy-4-methoxyphenyl) – 2-methylsulfonyl) ethylamine (compound V) or its salt obtained by reacting app Si Te. The preparation method is simple in operation, low energy consumption, high yield, suitable for industrial production. (by machine translation)

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H3450O – PubChem

Related Products of 6296-53-3, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 6296-53-3, molcular formula is C10H7NO4, introducing its new discovery.

Processes for the preparation of certain isoindole compounds, and isotopologues thereof, are provided. In some embodiments, the processes comprise catalytic assymetrical hydrogenation with hydrogen gas or deuterium gas in a solvent containing exchangeable proton or deuterium for proton-deuterium exchange.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 6296-53-3 is helpful to your research. Related Products of 6296-53-3

Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H3423O – PubChem

Chemistry is traditionally divided into organic and inorganic chemistry. Application In Synthesis of N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent，Which mentioned a new discovery about 6296-53-3

Administration of apremilast in a specific dosage titration schedule, alone or in combination with a second active agent for use in methods of treating, managing or preventing diseases ameliorated by inhibiting PDE4 such as psoriasis, ankylosing spondylitis, Behcet’s disease, rheumatoid arthritis, atopic dermatitis, Crohn’s disease, and ulcerative colitis.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H3426O – PubChem

Application of 6296-53-3, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.6296-53-3, Name is N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide, molecular formula is C10H7NO4. In a Patent，once mentioned of 6296-53-3

The synthesizing method 2 – of.acetyl – 6 6-amido benzoate 3 – has the characteristics 2 – of easily available,route short, route, high, yield, easy operation, environment pollution and the like, and is suitable for large-scale industrial production, The method is suitable for. large-scale industrial production of the target product, acetyl – 6 6-amido benzoate. (by machine translation)

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 6296-53-3

Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H3447O – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Product Details of 6296-53-3, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 6296-53-3, Name is N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide, molecular formula is C10H7NO4

The present invention relates to new crystalline forms of apps is special, compared with the solid form of apps especially known, new crystalline form of the present invention has good stability, have advantageous processing and handling characteristics, is suitable for solid preparation application. The invention also relates to a process for the preparation of the new crystalline form, its pharmaceutical compositions, and their use for the preparation of a medicament for the treatment of arthritis and psoriasis in use. (by machine translation)

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Product Details of 6296-53-3, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 6296-53-3, in my other articles.

Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H3465O – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, name: N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 6296-53-3, Name is N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide, molecular formula is C10H7NO4

The invention discloses a high optical purity of formula I shown in the preparation method of the app Si Te, the resulting product and its application. The invention of the preparation method of the app Si Te, through IV and compound to compound V as reaction raw material, glacial acetic acid as reaction solvent in the condensation reaction, the use of selected from anhydrous magnesium sulfate, anhydrous sodium sulfate, anhydrous calcium chloride, anhydrous copper sulfate or anhydrous molecular sieve catalysts such as, make this invention app Si Te preparation method has high-efficient, high yield, the characteristics of high optical purity, is more suitable for industrial production; the resulting app Si Te high optical purity of the product, used as material preparing into medicines, will have better curative effect, so as to improve the treatment of patient compliance. (by machine translation)

One of the oldest and most widely used commercial enzyme inhibitors is aspirin, name: N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 6296-53-3

Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H3438O – PubChem

Synthetic Route of 6296-53-3, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.6296-53-3, Name is N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide, molecular formula is C10H7NO4. In a article，once mentioned of 6296-53-3

The invention discloses a process for preparing high optical purity apps is special method, comprises the following steps: in the aromatic hydrocarbon solvent, the (S)- 2 – (3 – ethoxy – 4 – methoxyphenyl) – 1 – (methylsulfonyl) – b – 2 – ylamine or a salt thereof with 3 – acetyl amino phthalic anhydride in the amination reaction, make apps is special. Using the method of preparation of optical purity can be apps is special to the 99.9% or more. (by machine translation)

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 6296-53-3

Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H3445O – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, name: N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 6296-53-3, Name is N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide, molecular formula is C10H7NO4

The present invention is directed to a novel process for the preparation of Apremilast in amorphous form directly from the crude reaction mixture comprising the final stage condensation of a 3- acetamidophthalic anhydride and a chiral amino acid salt of (S)-2-(3-ethoxy-4-methoxyphenyl)-1- (methylsulfonyl)-eth-2-ylamine, isolated in amorphous form using a solvent-antisolvent mixture comprising acetonitrile-water, dimethylformamide-water, dimethylsulfoxide-water, acetonitrile- dimethylformamide-water or mixtures thereof.

One of the oldest and most widely used commercial enzyme inhibitors is aspirin, name: N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 6296-53-3

Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H3430O – PubChem