Category: 6296-53-3

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. Application In Synthesis of N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide. Introducing a new discovery about 6296-53-3, Name is N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide

A method for purification of the product apps is special method (by machine translation)

The invention discloses a purification method for Apremilast in the preparation process. The purification method comprises steps as follows: (1), acid anhydride and chiral amine serving as reaction raw materials have a reaction in glacial acetic acid serving as a solvent, TLC (thin-layer chromatography) is used for detecting the reaction, after the chiral amine has a complete reaction, acetic anhydride is added, a reaction is performed for 1-1.5 h, glacial acetic acid is evaporated, residues are poured into water and stirred, suspended substances are formed, and coarse Apremilast products are obtained after suction filtration, filter cake washing and drying; (2), the coarse Apremilast prodcuts are added to EtOH, heating reflux is performed for 1-3 h, the mixture is cooled to the room temperature while being stirred, and the pure Apremilast products are obtained after vacuum suction filtration, filter cake washing and drying. Acid anhydride is added after the principal reaction is finished, and the pure Apremilast products with the purity higher than 99.9% can be obtained just through one-time crystallization, and the total yield is increased by more than 20%.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Application In Synthesis of N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide, you can also check out more blogs about6296-53-3

Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H3478O – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Formula: C10H7NO4, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 6296-53-3, Name is N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide, molecular formula is C10H7NO4

A method for preparing apps is special (by machine translation)

The invention discloses a method for preparing apps is special, the intermediate (1S) -1 – (3 – ethoxy -4 – methoxyphenyl) -2 – (methyl sulfonyl) b the ammonia passes through the oxidation reaction (1S) -1 – (3 – ethoxy -4 – methoxyphenyl) -2 – (methyl sulfonyl) b ammonia, with 3 – acetyl amino phthalic anhydride reaction preparation apps is special. The method through the chiral induced mode, the use of sterically hindered in the preparation of intermediate (1S) -1 – (3 – ethoxy -4 – methoxyphenyl) -2 – (methyl sulfonyl) b ammonia introduced to the chiral center. Compared with the prior art to avoid the use of N – acetyl – L – leucine splitting step, simplifies the synthesis routes, high yield, low cost, and is suitable for industrial mass production. (by machine translation)

One of the oldest and most widely used commercial enzyme inhibitors is aspirin, Formula: C10H7NO4, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 6296-53-3

Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H3433O – PubChem

Reference of 6296-53-3, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.6296-53-3, Name is N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide, molecular formula is C10H7NO4. In a article£¬once mentioned of 6296-53-3

CRYSTALLINE FORMS OF APREMILAST

The invention particularly relates to crystailine (solid) forms of N-[2-[(1S)-1-(3-ethoxy-4- methoxyphenyl)-2-(methylsulfonyl)ethyl]-1,3-dioxo-2,3-dihydro-1 H-isoindol-4-yl]acetamide), i.e. Form N, Form M, Form O and Form P. It also refers to a pharmaceutical composition or dosage form comprising said crystalline forms. The invention also concerns said pharmaceuticai composition or dosage form for use in a method of treating a disease or disorder defined in the claims. Finally, the invention pertains to the use of said novel crystalline forms for the preparation of a pharmaceutical composition or dosage form.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 6296-53-3

Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H3454O – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Product Details of 6296-53-3, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 6296-53-3, Name is N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide, molecular formula is C10H7NO4

A SYNTHETIC PATHWAY TOWARDS APREMILAST

The present invention relates to an asymmetric process for providing N-{2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}acetamide (apremilast) or a pharmaceutically acceptable salt or solvate thereof.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Product Details of 6296-53-3, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 6296-53-3, in my other articles.

Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H3468O – PubChem

Related Products of 6296-53-3, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.6296-53-3, Name is N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide, molecular formula is C10H7NO4. In a Patent£¬once mentioned of 6296-53-3

METHODS AND COMPOSITIONS USING PDE4 INHIBITORS FOR THE TREATMENT AND MANAGEMENT OF AUTOIMMUNE AND INFLAMMATORY DISEASES

Methods of treating, preventing, or managing autoimmune inflammatory diseases and disorders including but not limited to spondylitis, juvenile rheumatoid arthritis, psoriasis, psoriatic arthritis, osteoarthritis, ankylosing spondylitis, and rheumatoid arthritis by the administration of phosphodiesterase 4 (PDE4) inhibitors in combination with other therapeutics are disclosed. Pharmaceutical compositions, dosage forms, and kits suitable for use in methods of the invention are also disclosed.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 6296-53-3, and how the biochemistry of the body works.Related Products of 6296-53-3

Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H3461O – PubChem

6296-53-3, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In a patent, 6296-53-3, molecular formula is C10H7NO4, introducing its new discovery.

A high-purity apps is special refining preparation process (by machine translation)

The invention discloses a high-purity apps is special refining preparation process, comprising the following steps: (1) to anhydride and chiral amine as the raw material, the solvent in the A heating reflux 2 – 5 h, after processing by the apps is especially thick; (2) will be added to the solvent in the B apps is especially thick, heated and dissolved, mixture through refined apps special sterling; the invention through water and 2 – butanone compound as a purification solvent removing impurities, and have achieved good technical effect, can remarkably reduce the apps is especially thick intermediate a main impurity in the raw materials, intermediate b and process the content of the impurity, HPLC detection apps is special purity of 99.7% or more, the impurity limit is less than 0.1%. (by machine translation)

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.6296-53-3, you can also check out more blogs about6296-53-3

Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H3444O – PubChem

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent£¬Which mentioned a new discovery about 6296-53-3, molcular formula is C10H7NO4, introducing its new discovery. , 6296-53-3

NOVEL PROCESS TO PREPARE N-[2-[(1S)-1-(3-ETHOXY-4-METHOXYPHENYL)-2-(METHYLSULPHONYL) ETHYL]-1, 3-DIOXO-2,3-DIHYDRO-1H-ISOINDOL-4-YL]ACETAMIDE

An alternative and improved process for the preparation of Apremilast (Formula I) and Apremilast form B or a pharmaceutically acceptable salt thereof is provided. The novel process includes hydrogenation in acetone, Cyclization and acetylation followed by condensation in methyl isobutyl ketone (MIBK) and acetic acid mixture in specific volume ratios.

Because enzymes can increase reaction rates by enormous factors and tend to be very specific, 6296-53-3, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 6296-53-3

Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H3459O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6296-53-3,N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide,as a common compound, the synthetic route is as follows.,6296-53-3

A stirred mixture of 5-amino-5-(3-ethoxy-4-methoxyphenyl)pentan-3-ol hydrochloride(1.15 g, 3.97 mmol), 3-acetamidophthalic anhydride (0.82 g, 3.97 mmol) and triethylamine (0.4 g, 3.97 mmol) in DMF (20 ML) was heated at 80-90¡ã C. for 6 hours. The mixture was then concentrated in vacuo. The residue was dissolved in ethyl acetate (80 ML), washed with water (30 ML), brine (30 ML) and dried over magnesium sulfate. The solvent was removed in vacuo and the residue was purified by chromatography (silica gel, methylene chloride:ethyl acetate 8:2) to give N-{2-[1-(3-ethoxy-4-methoxyphenyl)-3-hydroxypentyl]-1,3-dioxoisoindolin-4-yl}acetamide (1.35 g, 77percent); 1H NMR (CDCl3) delta9.52 (s, 1H), 8.71 (d, J=8.4 Hz, 1H), 7.63 (t, J=7.6 Hz, 1H), 7.48 (d, J=7.3 Hz, 1H), 7.09-7.07 (m, 2H), 6.83-6.80 (m, 1H), 5.61-5.55 (J=3.9, 11.9 Hz, 1H), 4.11 (q, J=6.9 Hz, 2H), 3.84 (s, 3H), 3.47 (m, 1H), 2.97-2.86 (m, 1H), 2.25 (s, 3H), 2.06-1.95 (m, 1H), 1.78 (b, 1H), 1.62-1.52 (m, 2H), 1.45 (t, J=7.0 Hz, 3H), 0.95 (t, J=7.3 Hz, 3H); 13C NMR (CDCl3) delta170.39, 169.23, 168.11, 148.94, 148.14, 137.32, 135.83, 131.81, 131.19, 124.72, 120.30, 117.94, 115.31, 112.87, 111.09, 70.01, 64.36, 55.86, 51.29, 37.92, 30.46, 24.92, 14.73, 9.90.

6296-53-3 N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide 226121, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; Celgene Corporation; US6667316; (2003); B1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6296-53-3,N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide,as a common compound, the synthetic route is as follows.

6296-53-3, [0093] A stirred solution of l-(3-ethoxy-4-methoxyphenyl)-2- methylsulfonylethylamine (1.0 g, 3.7 mmol) and 3-acetamidophthalic anhydride (751 mg, 3.66 mmol) in acetic acid (20 mL) was heated at reflux for 15 h. The solvent was removed in vacuo to yield an oil. Chromatography of the resulting oil yielded the product as a yellow solid (1.0 g, 59% yield): mp, 144 C; 1H NMR (CDC13) delta: 1.47 (t, J=7.0 Hz, 3H, CH3), 2.26 (s, 3H, CH3), 2.88 (s, 3H, CH3), 3.75 (dd, J=4.4, 14.3 Hz, 1H, CH), 3.85 (s, 3H, CH3), 4.11 (q, J=7 Hz, 2H, CH2), 5.87 (dd, J=4.3, 10.5 Hz, 1H, NCH), 6.82-6.86 (m, 1H, Ar), 7.09-7.11 (m, 2H, Ar), 7.47 (d, J= 7 Hz, 1H, Ar), 7.64 (t, J= 8 Hz, 1H, Ar), 8.74 (d, J= 8 Hz, 1H, Ar), 9.49 (br s, 1H, NH); 13C NMR (CDC13) delta: 14.61, 24.85, 41.54, 48.44, 54.34, 55.85, 64.43, 111.37, 112.34, 115.04, 118.11, 120.21, 124.85, 129.17, 130.96, 136.01, 137.52, 148.54, 149.65, 167.38, 169.09, 169.40; Anal Calc’d. for C22H24NO7S : C, 57.38; H, 5.25; N, 6.08. Found: C, 57.31; H, 5.34; N, 5.83.

As the paragraph descriping shows that 6296-53-3 is playing an increasingly important role.

Reference£º
Patent; CELGENE CORPORATION; DAY, Robert; (60 pag.)WO2016/25686; (2016); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

6296-53-3,6296-53-3, N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

10213] A stirred solution of 1-(3-ethoxy-4-methoxyphe- nyl)-2-methyl sulfonylethylamine (1.0 g, 3.7 mmol) and 3-acetamidophthalic anhydride (751 mg, 3.66 mmol) in acetic acid (20 mL) was heated at reflux for 15 h. The solvent was removed in vacuo to yield an oil. Chromatography of the resulting oil yielded the product as a yellow solid (1.0 g, 59% yield): mp, 144 C.; ?H NMR (CDC13) oe: 1.47 (t, J=7.0 Hz, 3H, CH3), 2.26 (s, 3H, CH3), 2.88 (s, 3H, CH3), 3.75 (dd, J=4.4, 14.3 Hz, 1H, CH), 3.85 (s, 3H, CH3), 4.11 (q, J=7 Hz, 2H, CH2), 5.87 (dd, J=4.3, 10.5 Hz, 1H, NCH), 6.82-6.86 (m, 1H, Ar), 7.09-7.11 (m, 2H, Ar), 7.47 (d, J=7 Hz, 1H, Ar), 7.64 (t, J=8 Hz, 1H, Ar), 8.74 (d, J=8 Hz, 1H, Ar), 9.49 (br s, 1H, NH); ?3CNMR (CDC13) oe: 14.61,24.85,41.54,48.44,54.34, 55.85, 64.43, 111.37, 112.34, 115.04, 118.11, 120.21, 124.85, 129.17, 130.96, 136.01, 137.52, 148.54, 149.65, 167.38,169.09, 169.40; Anal Calc?d. for C22H24N075: C, 57.38; H, 5.25; N, 6.08. Found: C, 57.31; H, 5.34; N, 5.83.

As the paragraph descriping shows that 6296-53-3 is playing an increasingly important role.

Reference£º
Patent; Celgene Corporation; CHEN, Ming J.; HUI, HO-WAH; SHEN, XIAOLE; (48 pag.)US2016/128981; (2016); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem