Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. Application In Synthesis of N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide. Introducing a new discovery about 6296-53-3, Name is N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide
A method for purification of the product apps is special method (by machine translation)
The invention discloses a purification method for Apremilast in the preparation process. The purification method comprises steps as follows: (1), acid anhydride and chiral amine serving as reaction raw materials have a reaction in glacial acetic acid serving as a solvent, TLC (thin-layer chromatography) is used for detecting the reaction, after the chiral amine has a complete reaction, acetic anhydride is added, a reaction is performed for 1-1.5 h, glacial acetic acid is evaporated, residues are poured into water and stirred, suspended substances are formed, and coarse Apremilast products are obtained after suction filtration, filter cake washing and drying; (2), the coarse Apremilast prodcuts are added to EtOH, heating reflux is performed for 1-3 h, the mixture is cooled to the room temperature while being stirred, and the pure Apremilast products are obtained after vacuum suction filtration, filter cake washing and drying. Acid anhydride is added after the principal reaction is finished, and the pure Apremilast products with the purity higher than 99.9% can be obtained just through one-time crystallization, and the total yield is increased by more than 20%.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Application In Synthesis of N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide, you can also check out more blogs about6296-53-3
Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H3478O – PubChem