Chemistry is traditionally divided into organic and inorganic chemistry. Computed Properties of C9H6O2, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 4265-16-1
Design, synthesis and biological evaluation of new embelin derivatives as CK2 inhibitors
A new series of furan embelin derivatives was synthesized and characterized as ATP-competitive CK2 inhibitors. The new compounds were efficiently synthesized using a multicomponent approach from embelin (1), aldehydes and isonitriles through a Knoevenagel condensation/Michael addition/heterocyclization. Several compounds with inhibitory activities in the low micromolar or even submicromolar were identified. The most active derivative was compound 4l (2-(tert-butylamino)-3-(furan-3-yl)-5-hydroxy-6-undecylbenzofuran-4,7-dione) with an IC50 value of 0.63 muM. It turned out to be an ATP competitive CK2 inhibitor with a Ki value determined to be 0.48 muM. Docking studies allowed the identification of key ligand-CK2 interactions, which could help to further optimize this family of compounds as CK2 inhibitors.
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Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H723O – PubChem