Tan, Yong-Xia’s team published research in Fitoterapia in 81 | CAS: 56317-21-6

Fitoterapia published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C20H12N2O2, Recommanded Product: 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol.

Tan, Yong-Xia published the artcileBioactive 2-arylbenzofuran derivatives from Morus wittiorum, Recommanded Product: 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, the publication is Fitoterapia (2010), 81(7), 742-746, database is CAplus and MEDLINE.

Investigation of an ethanol extract from the stem bark of Morus wittiorum led to the isolation of five new 2-arylbenzofuran derivatives that were named wittifuran S, wittifuran T, wittifuran V, wittifuran W and wittifuran X (1-5). Structures were determined on the basis of spectroscopic anal. Two new wittifurans and five previously isolated compounds were assayed for antioxidant and anti-inflammatory activity.

Fitoterapia published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C20H12N2O2, Recommanded Product: 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Wang, Lei’s team published research in Journal of Asian Natural Products Research in 12 | CAS: 56317-21-6

Journal of Asian Natural Products Research published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C25H47NO8, HPLC of Formula: 56317-21-6.

Wang, Lei published the artcileThree new compounds from Morus nigra L., HPLC of Formula: 56317-21-6, the publication is Journal of Asian Natural Products Research (2010), 12(6), 431-437, database is CAplus and MEDLINE.

A new 2-arylbenzofuran derivative, mornigrol D (1), along with two new flavones, mornigrol G (2) and mornigrol H (3), and six known compounds, norartocarpetin (4), dihydrokaempferol (5), albanin A (6), albanin E (7), moracin M (8), and albafuran C (9), were isolated from the barks of Morus nigra. Their structures were elucidated by spectroscopic anal. Compounds 1 and 9 showed antioxidative activities in vitro with inhibition ratios of 98 and 99% at the concentration of 10-4 mol/l, and of 74 and 75% at the concentration of 10-5 mol/l. In addition, compounds 1 and 4 showed potent anti-inflammatory activities (inhibition of release of β-glucuronidase from rat polymorphonuclear leukocytes induced by platelet activating factor) with inhibitory ratios of 65.9% (P < 0.01) and 67.7% (P < 0.01) at a concentration of 10-5 mol/l.

Journal of Asian Natural Products Research published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C25H47NO8, HPLC of Formula: 56317-21-6.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Celaje, Jeff A.’s team published research in Organic Letters in 13 | CAS: 56317-21-6

Organic Letters published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C14H10O4, HPLC of Formula: 56317-21-6.

Celaje, Jeff A. published the artcileChemistry of trans-Resveratrol with Singlet Oxygen: [2 + 2] Addition, [4 + 2] Addition, and Formation of the Phytoalexin Moracin M, HPLC of Formula: 56317-21-6, the publication is Organic Letters (2011), 13(18), 4846-4849, database is CAplus and MEDLINE.

Resveratrol reacts with singlet oxygen by two major pathways: A [2 + 2] cycloaddition forming a transient dioxetane that cleaves into the corresponding aldehydes and a [4 + 2] cycloaddition forming an endoperoxide that, upon heating, undergoes a rearrangement to moracin M. The rate constant by which singlet oxygen is removed by resveratrol (kT) was determined by time-resolved IR luminescence spectroscopy to be 1.5 × 106 M-1 sec-1 in CD3OD, smaller than previously reported values. Chem. reaction accounts for ca. 25% of kT.

Organic Letters published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C14H10O4, HPLC of Formula: 56317-21-6.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Yang, Pei-Song’s team published research in Heterocycles in 92 | CAS: 56317-21-6

Heterocycles published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C15H20BNO3, SDS of cas: 56317-21-6.

Yang, Pei-Song published the artcileTwo new 2-arylbenzofurans from the stems of Nicotiana tabacum and their bioactivities, SDS of cas: 56317-21-6, the publication is Heterocycles (2016), 92(8), 1462-1467, database is CAplus.

Two new 2-arylbenzofurans, 4-(7-methoxy-3,5-dimethyl-benzofuran-2-yl)phenol (1), 4-(6-methoxy-3,5-dimethylbenzofuran-2-yl)-phenol (2), together with two known 2-arylbenzofurans (3 and 4) were isolated from the stems of Nicotiana tabacum. Their structures were determined by means of HRESIMS and extensive 1D and 2D NMR spectroscopic studies. Compounds 1-4 were tested for their anti-TMV and cytotoxicity activities. The results showed that compound 2 exhibited high anti-TMV activities with inhibition rates of 36.4% at the concentration of 20 μM. This rate is higher than that of pos. control. Compounds 1-4 showed moderate-to-weak cytotoxicities against some tested human tumor cell lines with IC50 values in the range of 2.2-8.4 μM.

Heterocycles published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C15H20BNO3, SDS of cas: 56317-21-6.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Jing, Ying’s team published research in Tianran Chanwu Yanjiu Yu Kaifa in 22 | CAS: 56317-21-6

Tianran Chanwu Yanjiu Yu Kaifa published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C14H10O4, Category: benzofurans.

Jing, Ying published the artcileChemical constituents from the leaves of Morus mongolica, Category: benzofurans, the publication is Tianran Chanwu Yanjiu Yu Kaifa (2010), 22(2), 181-184, database is CAplus.

Chem. constituents of the leaves of Morus mongolica were isolated and purified by ion-exchange resin, silica gel, ODS and Sephadex LH-20 column chromatogs. Their structures were elucidated on the basis of physico-chem. properties and spectral data. Ten compounds were identified as 1-deoxynojirimycin (1), fagomine (2), myoinositol (3), moracin M (4), 3-O-β-D-glucopyranoside (5), umbelliferone (6), scopoletin (7), syringaresinol (8), 2,4,2′,4′-tetrahydroxychalcone (9), and daucosterol (10), resp. Compounds 2, 3, 5-10 were isolated from this plant for the first time, and compound 9 is a new natural product.

Tianran Chanwu Yanjiu Yu Kaifa published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C14H10O4, Category: benzofurans.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Chen, Shang-Ke’s team published research in Bioorganic & Medicinal Chemistry Letters in 22 | CAS: 56317-21-6

Bioorganic & Medicinal Chemistry Letters published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C14H10O4, Application In Synthesis of 56317-21-6.

Chen, Shang-Ke published the artcileMoracin M from Morus alba L. is a natural phosphodiesterase-4 inhibitor, Application In Synthesis of 56317-21-6, the publication is Bioorganic & Medicinal Chemistry Letters (2012), 22(9), 3261-3264, database is CAplus and MEDLINE.

Phosphodiesterase-4 (PDE4) has been identified to be a promising target for treatment of asthma. Moracin M extracted from Chinese herbal drug ‘Sang-Bai-Pi’ (Morus alba L.) was studied for the inhibitory affinity towards PDE4. It inhibited PDE4D2, PDE4B2, PDE5A1, and PDE9A2 with the IC50 values of 2.9, 4.5, >40, and >100 μM, resp. Our mol. docking and 8 ns mol. dynamics (MD) simulations demonstrated that moracin M forms three hydrogen bonds with Gln369, Asn321, and Asp318 in the active site and stacks against Phe372. In addition, comparative kinetics anal. of its analog moracin C was carried out to qual. validate their inhibitory potency as predicted by the binding free energy calculations after MD simulations.

Bioorganic & Medicinal Chemistry Letters published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C14H10O4, Application In Synthesis of 56317-21-6.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Arias, Leire’s team published research in Journal of Organic Chemistry in 77 | CAS: 56317-21-6

Journal of Organic Chemistry published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C14H10O4, Related Products of benzofurans.

Arias, Leire published the artcileRegioselective Preparation of Benzo[b]furans from Phenols and α-Bromoketones, Related Products of benzofurans, the publication is Journal of Organic Chemistry (2012), 77(1), 266-275, database is CAplus and MEDLINE.

A fully regiocontrolled synthesis of either 2- and 3-substituted benzo[b]furans is described. Direct reaction between phenols and α-bromoacetophenones in the presence of neutral alumina yields 2-substituted benzo[b]furans with complete regiocontrol. When a basic salt such as potassium carbonate is used, the corresponding 2-oxoether is obtained. Cyclization of these latter compounds promoted by neutral alumina yields the corresponding 3-substituted benzo[b]furans. Using the former method, Moracin M and other analogs can be obtained from com. sources in two preparative steps. DFT calculations provide reasonable reaction paths to understand the formation of 2-substituted benzo[b]furans.

Journal of Organic Chemistry published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C14H10O4, Related Products of benzofurans.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Ristivojevic, Petar M.’s team published research in Journal of Chromatography A in 1594 | CAS: 56317-21-6

Journal of Chromatography A published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C14H10O4, Formula: C14H10O4.

Ristivojevic, Petar M. published the artcileHigh-performance thin-layer chromatography/bioautography and liquid chromatography-mass spectrometry hyphenated with chemometrics for the quality assessment of Morus alba samples, Formula: C14H10O4, the publication is Journal of Chromatography A (2019), 190-198, database is CAplus and MEDLINE.

Quality control is a crucial step in the production of effective and safe herbal remedies. The aim of this study was to develop a new, simple, and high throughput procedure for the quality assessment of herbal drugs using a high-performance thin-layer chromatog. (HPTLC)/bioautog. and UPLC-MS/MS approach combined with chemometrics. This was exemplarily shown for Morus alba L. root bark (sang bai pi; SBP). Bioautog. assays were developed for the identification of constituents with radical scavenging (DPPH assay) and antimicrobial activities (Bacillus subtilis, Escherichia coli) of 18 different M. alba samples, which was supported by UPLC-MS/MS anal. Further, the combination of bioautog. and chemometrics identified those samples with the most bioactive constituents. Plant materials collected from Serbia (11 samples) showed higher both radical scavenging and antimicrobial activities compared to samples provided from China (7 samples). Principal component anal. (PCA) confirmed the discrimination of geog. different samples and recognized their main markers responsible for differences between Serbian and Chinese samples. Most importantly for quality assessment, the combined HPTLC/bioautog. and UPLC-MS/MS approach not only allowed for a fast chem. profiling of the investigated samples and their unambiguous identification, but also for the disclosure of major and minor bioactive constituents present in SBP.

Journal of Chromatography A published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C14H10O4, Formula: C14H10O4.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Zhang, De-Wu’s team published research in Journal of Asian Natural Products Research in 17 | CAS: 56317-21-6

Journal of Asian Natural Products Research published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C18H34N4O5S, SDS of cas: 56317-21-6.

Zhang, De-Wu published the artcileNew 2-arylbenzofuran metabolite from cell cultures of Morus alba, SDS of cas: 56317-21-6, the publication is Journal of Asian Natural Products Research (2015), 17(6), 683-688, database is CAplus and MEDLINE.

A new 2-arylbenzofuran compound, 5-dehydroxy-moracin U (1), along with 10 known compounds (2-11), were isolated from cell cultures of Morus alba. Their structures were elucidated on the basis of extensive spectroscopic analyses. The anti-inflammatory activity assay of – showed that and exhibited significant inhibitory effect on LPS-induced NO production with the values of 76.4% and 98.7% at 10 5 M, resp.

Journal of Asian Natural Products Research published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C18H34N4O5S, SDS of cas: 56317-21-6.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Zhang, Long’s team published research in Molecules in 21 | CAS: 56317-21-6

Molecules published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C24H12, Recommanded Product: 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol.

Zhang, Long published the artcileCharacterization of a new flavone and tyrosinase inhibition constituents from the twigs of Morus Alba L, Recommanded Product: 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, the publication is Molecules (2016), 21(9), 1130/1-1130/9, database is CAplus and MEDLINE.

The twigs of Morus alba.L were found to show strong tyrosinase inhibition activity, and the responsible active components in the extract were further investigated in this study. A flavone, named morusone (1), and sixteen known compounds 2-17 were isolated from M. alba twigs and their structures were identified by interpretation of the corresponding ESI-MS and NMR spectral data. In the tyrosinase inhibitory test, the compounds steppogenin (IC50 0.98 ± 0.01 μM), 2,4,2′,4′-tetrahydroxychalcone (IC50 0.07 ± 0.02 μM), morachalcone A (IC50 0.08 ± 0.02 μM), oxyresveratrol (IC50 0.10 ± 0.01 μM), and moracin M (8.00 ± 0.22 μM) exhibited significant tyrosinase inhibition activities, much stronger than that of the pos. control kojic acid. These results suggest that M. alba twig extract should served as a good source of natural tyrosinase inhibitors for use in foods as antibrowning agents or in cosmetics as skin-whitening agents.

Molecules published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C24H12, Recommanded Product: 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem