Category: 5471-63-6

《Spectroscopic and theoretical methods to probe protein-ligand binding》 was published in Materials Today: Proceedings in 2020. These research results belong to Sreedhanya, S.; Jeena, V. R.; Ammu, S.; Aravindakumar, C. T.; Aravind, Usha K.. Synthetic Route of C20H14O The article mentions the following:

Protein-ligand binding studies have gained considerable attention owing to its application in biomedical research. The present study discusses the application of spectroscopic and theor. methods to probe the interaction between a model ligand, 1, 3-diphenylisobenzofuran (DPBF) and bovine serum albumin (BSA). The quenching of the intrinsic fluorescence of BSA arising from tryptophan residue in the presence of DPBF is monitored to follow the nature and mechanism associated with the binding process. The binding affinity and number of binding sites have been investigated. Synchronous fluorescence and UV-Vis spectroscopic studies have been carried out to follow the changes in the fluorophore micro-environment and binding mechanism. Theor. methods such as fluorescence resonance energy transfer (FRET) and mol. docking are also employed to predict the binding mechanism, binding modes, binding sites and the distance between the tryptophan residue in BSA and DPBF. The experimental part of the paper was very detailed, including the reaction process of 1,3-Diphenylisobenzofuran(cas: 5471-63-6Synthetic Route of C20H14O)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used to study the single crystal molecular structure and solution photophysical properties of DPBF.Synthetic Route of C20H14O

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

《Fluorinated Phenanthrenes as Aryne Precursors: PAH Synthesis Based on Domino Ring Assembly Using 1,1-Difluoroallenes》 was written by Fuchibe, Kohei; Abe, Masashi; Idate, Hiroto; Ichikawa, Junji. Synthetic Route of C20H14O And the article was included in Chemistry – An Asian Journal in 2020. The article conveys some information:

On treatment with the catalyst InBr3, 1,1-difluoroallenes e.g., [1-(3,3-difluoropropa-1,2-dien-1-yl)cyclopent-3-en-1-yl]benzene that bear a cyclopentene moiety and an aryl group underwent domino ring assembly in the presence or absence of N-bromosuccinimide or N-iodosuccinimide to afford aryne precursors such as three-ringed ortho-fluoro(halo)phenanthrenes, four-ringed ortho-fluoro(halo)tetraphenes, ortho-fluoro(halo)chrysenes and 6-fluoro-benzo[c]phenanthrene. Metalation of the aryne precursors followed by elimination of the fluoride resulted in the unprecedented systematic generation of arynes bearing π-extended systems e.g., 9,14-dihydro-9,14-diphenyl-9,14-epoxybenzo[b]triphenylene. Diels-Alder reactions of these arynes with isobenzofurans afforded the corresponding cycloadducts e.g., I, whose reductive aromatization in an SnCl2/HBr system furnished fully aromatized benzotriphenylenes e.g., 9,14-diphenylbenzo[b]triphenylene. In addition, oxidative aryl-aryl coupling (Scholl reaction) of these benzotriphenylenes facilitated the synthesis of ‘half HBCs’ (hexabenzocoronenes) II (R1 = H, n-Hex, t-Bu). In addition to this study using 1,3-Diphenylisobenzofuran, there are many other studies that have used 1,3-Diphenylisobenzofuran(cas: 5471-63-6Synthetic Route of C20H14O) was used in this study.

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used as quencher during the photoinactivation of TA-3 mouse mammary carcinoma cells containing hematoporphyrin.Synthetic Route of C20H14O

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Luo, Huanhuan; Kong, Li; Zhang, Feng; Huang, Chenglong; Chen, Jiayi; Zhang, Hongbo; Yu, Han; Zheng, Song; Xu, Hongwei; Zhang, Yiran; Deng, Lianfu; Chen, Gang; Santos, Helder A.; Cui, Wenguo published an article in 2021. The article was titled 《Light-Controlled Nanosystem with Size-Flexibility Improves Targeted Retention for Tumor Suppression》, and you may find the article in Advanced Functional Materials.Safety of 1,3-Diphenylisobenzofuran The information in the text is summarized as follows:

Although great promise has been achieved with nanomedicines in cancer therapy, limitations are still encountered, such as short retention time in the tumor. Herein, a nanosystem that can modulate the particle size in situ by near-IR (NIR) light is self-assembled by crosslinking the surface-modified poly(lactic-co-glycolic acid) from the up-conversion nanoparticle with indocyanine green and doxorubicin-nitrobenezene-polyethylene glycol (DOX-NB-PEG). The nanosystem with its small size (100 nm) achieves better tumor targeting, while the PEG on the surface of the nanosystem can effectively shield the adsorption of proteins during blood circulation, maintaining a stable nanostructure and achieving good tumor targeting. Moreover, the nanosystem at the tumor realizes the rapid shedding of PEG on its surface by NIR irradiation, and the enhanced cellular uptake. At the same time, aggregation occurs inside the nanosystem to form bigger particles (600 nm) in situ, prolonging the retention time at the tumor and producing enhanced targeted therapeutic effects. In vitro data show higher cellular uptake and a higher rate of apoptosis after irradiation, and the in vivo data prove that the nanosystem have a longer residence time at the tumor site after NIR irradiation This nanosystem demonstrates an effective therapeutic strategy in targeted synergistic tumors. In the experiment, the researchers used 1,3-Diphenylisobenzofuran(cas: 5471-63-6Safety of 1,3-Diphenylisobenzofuran)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used as quencher during the photoinactivation of TA-3 mouse mammary carcinoma cells containing hematoporphyrin.Safety of 1,3-Diphenylisobenzofuran

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

《Tuning Optical Properties of BODIPY Dyes by Pyrrole Conjugation for Photoacoustic Imaging》 was written by Merkes, Jean Michel; Lammers, Twan; Kancherla, Rajesh; Rueping, Magnus; Kiessling, Fabian; Banala, Srinivas. Formula: C20H14O And the article was included in Advanced Optical Materials in 2020. The article conveys some information:

Photoacoustic imaging (PAI) is increasingly employed in (pre-) clin. research, thus, development of suitable contrast agents, in particular fluorescence-quenched chromophores, for PAI is of high importance. Small mol. dyes are appropriate due to favorable circulation, excretion properties, and ease of conjugation to targeting moieties. The BODIPY chromophores have been widely used in bioimaging, yet they are not ideal for PAI due to high fluorescence. Hence, here nonfluorescent BODIPY are designed by 1H-pyrrole conjugation (PyBODIPY) to apply as probes for PAI. The PyBODIPYs exhibit absorption maxima up to 800 nm, and PA signal could be detected in concentrations of 1 nmol mL-1 and 35 pmol mm-3, by tube and tissue phantom, resp. In addition to nonfluorescent, PyBODIPYs are non-phototoxic, photostable, and show high molar extinction coefficients, as well as inertness toward nucleophilic addition PyBODIPYs are modified with PEG-400, to improve aqueous solubility and to enable in vivo imaging. Thus, PyBODIPY is an attractive small mol. to use as PA contrast agent, which could be coupled to targeting ligands for in vivo use. In addition, 1H-pyrrole conjugation might be applied to the design of novel near-IR ranged quenchers suitable for PAI, and promote the development of probes for clin. translation. The experimental part of the paper was very detailed, including the reaction process of 1,3-Diphenylisobenzofuran(cas: 5471-63-6Formula: C20H14O)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used as quencher during the photoinactivation of TA-3 mouse mammary carcinoma cells containing hematoporphyrin.Formula: C20H14O

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

《Carrier-Free Triterpene Prodrugs with Glutathione Response and Biosafety for Synergistically Enhanced Photochemotherapy》 was written by Cheng, Jianjun; Li, Xinyu; Wang, Shu; Han, Ying; Zhao, Haitian; Yang, Xin. Related Products of 5471-63-6This research focused ontriterpene prodrug glutathione biosafety photochemotherapy; carrier-free; glutathione response; photochemotherapy; self-assembly; triterpene prodrugs. The article conveys some information:

Carrier-free pure drug self-assembled nanosystems have been proposed as a promising strategy for synergetic anticancer therapy. Herein, we purposefully designed and synthesized disulfide-modified glutathione (GSH)-responsive natural pentacyclic triterpene betulinic acid (BA) with better biodegradability and biocompatibility to construct carrier-free photosensitive prodrugs BA-S-S/Ce6 NPs for synergistically enhanced and biosafe photochemotherapy. The mol. dynamics simulation elucidates the possible coassembly mechanism that the coplanar arrangement of BA-S-S dimeric may be primarily responsible for the formation of a long lamella-like or spherical morphol. The d. functional theory calculations demonstrate that the reduced energy gap (ΔEST) of Ce6 facilitates the improved singlet oxygen generation of BA-S-S/Ce6 nanoparticles (NPs). The assembled prodrugs exhibited remarkable GSH-responsive property and multiple favorable therapeutic features, leading to enhanced synergistic antitumor efficacy without noticeable toxicity. Addnl., evaluation of the antitumor efficacy of another tetracyclic triterpene stigmasterol (ST)-mediated ST-S-S/Ce6 NPs further confirmed the effectiveness of this rational design. This work provides a promising insight for exploring the pure drug self-assembly behavior and construction of GSH-responsive carrier-free triterpenoid prodrugs toward improved multiple combination antitumor therapies. The results came from multiple reactions, including the reaction of 1,3-Diphenylisobenzofuran(cas: 5471-63-6Related Products of 5471-63-6)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) is a fluorescent dye. 1,3-Diphenylisobenzofuran is the model compound in studies of singlet fission.Related Products of 5471-63-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

SDS of cas: 5471-63-6In 2020 ,《Lifetime and diffusion distance of singlet oxygen in air under everyday atmospheric conditions》 was published in Physical Chemistry Chemical Physics. The article was written by Wang, Kang-Kyun; Song, Sanggeun; Jung, Seung-Jin; Hwang, Jung-Wook; Kim, Min-Goo; Kim, Ji-Hyun; Sung, Jaeyoung; Lee, Jin-Kyu; Kim, Yong-Rok. The article contains the following contents:

Singlet oxygen is a toxic chem. but powerful oxidant, exploited in many chem. and biol. applications. However, the lifetime of singlet oxygen in air under atm. conditions is yet to be known. This has limited safe usage of singlet oxygen in air, despite being a strong antimicrobial agent with the unique property of relaxing to breathable oxygen after serving its purpose. Here, we solve this long-standing problem by combining exptl. and theor. research efforts; we generate singlet oxygen using a photosensitizer at a local source and monitor the time-dependent extent of singlet oxygen reaction with probe mols. at a detector, precisely controlling the detector distance from the source. To explain our exptl. results, we employ a theor. model that fully accounts for singlet oxygen diffusion, radiative and nonradiative relaxations, and the bimol. reaction with probe mols. at the detector. For all cases investigated, our model, with only two adjustable parameters, provides an excellent quant. explanation of the experiment From this anal., we extract the lifetime of singlet oxygen in the air to be 2.80 s at 23°C under 1 atm, during which time singlet oxygen diffuses about 0.992 cm. The correctness of this estimation is confirmed by a simple mean-first-passage time anal. of the maximum distance singlet oxygen can reach from the source. We also confirm the sterilization effects of singlet oxygen for distances up to 0.6-0.8 cm, depending on the bacteria strain in question, between the bacteria and the singlet oxygen source. In the part of experimental materials, we found many familiar compounds, such as 1,3-Diphenylisobenzofuran(cas: 5471-63-6SDS of cas: 5471-63-6)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) is a fluorescent dye. 1,3-Diphenylisobenzofuran is the model compound in studies of singlet fission.SDS of cas: 5471-63-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

In 2022,Zhang, Rui; Liu, Changlin; Zhao, Ruoxi; Du, Yaqian; Yang, Dan; Ding, He; Yang, Guixin; Gai, Shili; He, Fei; Yang, Piaoping published an article in Journal of Colloid and Interface Science. The title of the article was 《Engineering oxygen vacancy of MoOx nanoenzyme by Mn doping for dual-route cascaded catalysis mediated high tumor eradication》.SDS of cas: 5471-63-6 The author mentioned the following in the article:

There is an urgent need to develop photosensitive nanoenzymes with better phototherapeutic efficiency through simple processes. By exploiting semiconductor catalysis and defect chem. principles, herein, a MnMoOx composite semiconductor nanoenzyme was developed to achieve a fully integrated theranostic nanoenzyme for highly efficient photo/chemo-enzyme-dynamic eradication of deep tumors. Relative to iron oxides, manganese oxides offer ideal catalytic performance under near-neutral conditions, which helps to broaden the suitable pH range of the MnMoOx nanoenzyme for antitumor therapy. Furthermore, with the assistance of glutathione depletion, Mn4+/Mo6+ was successfully converted to Mn2+/Mo5+, inhibiting the scavenging of reactive oxygen species (ROS) and promoting cycling. Therefore, MnMoOx has favorable catalase (CAT)-like activity and oxidase (OXD)-like activity in the tumor microenvironment (TME) for promoting the “”H2O2-O2-·O2-“” and “”H2O2-·OH”” cascade reactions. The abundant oxygen vacancy defects also promote the surface plasmon resonance (SPR) effect in the second near-IR (NIR-II) window of MnMoOx, which significantly enhanced its photothermal therapy (PTT) effect and catalytic activity. In detail, ROS production was significantly enhanced due to the adsorption of water and oxygen mols. by the rich oxygen vacancies of MnMoOx. MnMoOx also exhibited excellent multi-modal imaging activity (including computed tomog. (CT), magnetic resonance imaging (MRI), and photoacoustic (PA)), which can be exploited to better guide the administration of medication. After reading the article, we found that the author used 1,3-Diphenylisobenzofuran(cas: 5471-63-6SDS of cas: 5471-63-6)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used as quencher during the photoinactivation of TA-3 mouse mammary carcinoma cells containing hematoporphyrin.SDS of cas: 5471-63-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Cao, Changyu; Zou, Hai; Yang, Nan; Li, Hui; Cai, Yu; Song, Xuejiao; Shao, Jinjun; Chen, Peng; Mou, Xiaozhou; Wang, Wenjun; Dong, Xiaochen published their research in Advanced Materials (Weinheim, Germany) in 2021. The article was titled 《Fe3O4/Ag/Bi2MoO6 Photoactivatable Nanozyme for Self-Replenishing and Sustainable Cascaded Nanocatalytic Cancer Therapy》.SDS of cas: 5471-63-6 The article contains the following contents:

Catalytic cancer therapy based on nanozymes has recently attracted much interest. However, the types of the current nanozymes are limited and their efficiency is usually compromised and not sustainable in the tumor microenvironment (TME). Therefore, combination therapy involving addnl. therapeutics is often necessary and the resulting complication may jeopardize the practical feasibility. Herein, an unprecedented “”all-in-one”” Fe3O4/Ag/Bi2MoO6 nanoparticle (FAB NP) is rationally devised to achieve synergistic chemodynamic, photodynamic, photothermal therapy with guidance by magnetic resonance, photoacoustic, and photothermal imaging. Based on its manifold nanozyme activities (mimicking peroxidase, catalase, superoxide dismutase, glutathione oxidase) and photodynamic property, cascaded nanocatalytic reactions are enabled and sustained in TME for outstanding therapeutic outcomes. The working mechanisms underlying the intraparticulate interactions, sustainability, and self-replenishment arising from the coupling between the nanocatalytic reactions and nanozyme activities are carefully revealed, providing new insights into the design of novel nanozymes for nanocatalytic therapy with high efficiency, good specificity, and low side effects. In the part of experimental materials, we found many familiar compounds, such as 1,3-Diphenylisobenzofuran(cas: 5471-63-6SDS of cas: 5471-63-6)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used to study the single crystal molecular structure and solution photophysical properties of DPBF.SDS of cas: 5471-63-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Hadi, Marym Mohammad; Nesbitt, Heather; Masood, Hamzah; Sciscione, Fabiola; Patel, Shiv; Ramesh, Bala S.; Emberton, Mark; Callan, John F.; MacRobert, Alexander; McHale, Anthony P.; Nomikou, Nikolitsa published their research in Journal of Controlled Release in 2021. The article was titled 《Investigating the performance of a novel pH and cathepsin B sensitive, stimulus-responsive nanoparticle for optimized sonodynamic therapy in prostate cancer》.Reference of 1,3-Diphenylisobenzofuran The article contains the following contents:

Nano-formulations that are responsive to tumor-related and externally-applied stimuli can offer improved, site-specific antitumor effects, and can improve the efficacy of conventional therapeutic agents. Here, we describe the performance of a novel stimulus-responsive nanoparticulate platform for the targeted treatment of prostate cancer using sonodynamic therapy (SDT). The nanoparticles were prepared by self-assembly of poly(L-glutamic acid-L-tyrosine) co-polymer with hematoporphyrin. The nanoparticulate formulation was characterized with respect to particle size, morphol., surface charge and singlet oxygen production during ultrasound exposure. The response of the formulation to the presence of cathepsin B, a proteolytic enzyme that is overexpressed and secreted in the tumor microenvironment of many solid tumors, was assessed. Our results showed that digestion with cathepsin B led to nanoparticle size reduction In the absence of ultrasound, the formulation exhibited greater toxicity at acidic pH than at physiol. pH, using the human prostate cells lines LNCaP and PC3 as targets. Nanoparticle cellular uptake was enhanced at acidic pH – a condition that was also associated with greater cathepsin B production Nanoparticles exhibited enhanced ultrasound-induced cytotoxicity against both prostate cancer cell lines. Subsequent proof-of-concept in vivo studies demonstrated that, when ectopic human xenograft LNCaP tumors in SCID mice were treated with SDT using the systemically-administered nanoparticulate formulation at a single dose, tumor volumes decreased by up to 64% within 24 h. No adverse effects were observed in the nanoparticle-treated mice and their body weight remained stable. The potential of this novel formulation to deliver safe and effective treatment of prostate cancer is discussed. The results came from multiple reactions, including the reaction of 1,3-Diphenylisobenzofuran(cas: 5471-63-6Reference of 1,3-Diphenylisobenzofuran)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used to study the single crystal molecular structure and solution photophysical properties of DPBF.Reference of 1,3-Diphenylisobenzofuran

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Chen, Wei; Liu, Chuang; Ji, Xiaoyuan; Joseph, John; Tang, Zhongmin; Ouyang, Jiang; Xiao, Yufen; Kong, Na; Joshi, Nitin; Farokhzad, Omid C.; Tao, Wei; Xie, Tian published their research in Angewandte Chemie, International Edition in 2021. The article was titled 《Stanene-Based Nanosheets for β-Elemene Delivery and Ultrasound-Mediated Combination Cancer Therapy》.Name: 1,3-Diphenylisobenzofuran The article contains the following contents:

Ultrasound (US)-mediated sonodynamic therapy (SDT) has emerged as a superior modality for cancer treatment owing to the non-invasiveness and high tissue-penetrating depth. However, developing biocompatible nanomaterial-based sonosensitizers with efficient SDT capability remains challenging. Here, we employed a liquid-phase exfoliation strategy to obtain a new type of two-dimensional (2D) stanene-based nanosheets (SnNSs) with a band gap of 2.3 eV, which is narrower than those of the most extensively studied nano-sonosensitizers, allowing a more efficient US-triggered separation of electron (e-)-hole (h+) pairs for reactive oxygen species (ROS) generation. In addition, we discovered that such SnNSs could also serve as robust near-IR (NIR)-mediated photothermal therapy (PTT) agents owing to their efficient photothermal conversion, and serve as nanocarriers for anticancer drug delivery owing to the inherent 2D layered structure. This study not only presents general nanoplatforms for SDT-enhanced combination cancer therapy, but also highlights the utility of 2D SnNSs to the field of nanomedicine. The results came from multiple reactions, including the reaction of 1,3-Diphenylisobenzofuran(cas: 5471-63-6Name: 1,3-Diphenylisobenzofuran)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used to study the single crystal molecular structure and solution photophysical properties of DPBF.Name: 1,3-Diphenylisobenzofuran

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem