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A facile protocol that enables synthetic interconversion of CUR-BF2 and CUR compounds is described that significantly widens the preparative scope of curcuminoids, providing access to larger libraries of compounds, thus enabling comparative antiproliferative and apoptotic study of a larger library of synthetic analogs in cancer cell lines.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H1161O – PubChem

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Ru-catalyzed alkylation of 3-formylbenzofuran with acrylates and acrylamides has been described. Branched selectivity with unsubstituted or beta-substituted acrylates/acrylamides and linear selectivity with alpha-substituted acrylates have been observed. However, in all of the cases, the intermediate alkylation products seem to undergo further reactions, either cycloannulation or deformylation, depending on the substrate employed. For example, with methyl acrylate, the intermediate branched alkylation product underwent cycloannulation with another molecule of methyl acrylate, resulting in a densely functionalized cyclohexene ring formation. On the other hand, in the case of N-monosubstituted acrylamides, the branched alkylation proceeded with intramolecular aldehyde-amide condensation, leading to pyridin-2-one ring annulation. However, with both methacrylate and crotonate, deformylation of the initially formed alkylation products was observed.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H1213O – PubChem

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The present invention provides a compound represented by formula (I), wherein the compound is represented by formula (I). A conformational isomer, or an optical isomer, or a pharmaceutically acceptable salt thereof. The compounds represented by the formula (I) have good, broad-spectrum inhibitory activity on MBL and/or SBL enzymes, and can be used for preparing MBL and/or SBL enzyme inhibitors. In addition, the compound has excellent antibacterial activity on various drug-resistant bacteria, can reverse drug resistance, and has an antibacterial effect superior to L -captopril, of a positive control product. Is tazobactam. The compound disclosed by the invention has great potential in preparation MBL/SBL a medicament for preventing drug resistance of carbapenem resistant bacteria by using a dual inhibitor and reversal of carbapenem resistance. (by machine translation)

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H1150O – PubChem

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Thiazole derivatives represented by Formula (I) are disclosed, where R1, R2, R3, A, X, Y, Z, R6 and R7 are disclosed herein. These thiazole derivatives and pharmaceutical compositions comprising these derivatives are useful in the treatment of HIV mediated diseases and conditions

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Benzofuran – Wikipedia,
Benzofuran | C8H1156O – PubChem

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Cyclopropyl-cyclopropyl rearrangement can be achieved selectively by intramolecular trapping of cyclopropylmethyl carbenium ions with an internal nucleophile. This can be exploited as a useful method for the introduction of a cyclopropyl group into complex molecules using readily accessible disubstituted cyclopropane intermediates.

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Benzofuran – Wikipedia,
Benzofuran | C8H1210O – PubChem

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The benzofuran-3-acetic acids (3a-c) on treatment with pyridine N-oxide give benzofuran-3-carboxyaldehydes (5a-c) on reduction with NaBH4 in methanol yields naturally occurring benzofuran 6a which is converted into 6b and 6c by the literature method.

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Benzofuran – Wikipedia,
Benzofuran | C8H1178O – PubChem

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Asymmetric dearomatic diels-alder reactions of diverse heteroarenes via pi-system activation

An asymmetric dearomatic Diels-Alder protocol for various heteroarenes, such as benzofuran, benzothiophene, or even furan, has been developed via pi-system activation. This method involves in situ generation of formal trienamine species embedding a heteroaromatic moiety, and an array of chiral fused frameworks with high molecular complexity and skeletal diversity were efficiently constructed in good to excellent stereoselectivity by the catalysis of a cinchona-based primary amine.

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Benzofuran – Wikipedia,
Benzofuran | C8H1220O – PubChem

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Synthesis of imidazopyridine-fused indoles via one-pot sequential Knoevenagel condensation and cross dehydrogenative coupling

A simple and efficient strategy for the synthesis of imidazopyridine-fused indoles has been developed that involves one-pot sequential Knoevenagel condensation of readily available active methylene azoles with N-substituted-1H-indole-3-carboxaldehydes or N-substituted-1H-indole-2-carboxaldehydes followed by palladium-catalyzed intramolecular cross dehydrogenative coupling reaction. A series of 36 derivatives was prepared by using this strategy. The products were obtained in moderate to excellent (32-94%) yields and showed broad substrate scope with tolerance of various functional groups and was amiable for gram scale preparation without problems.

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Benzofuran – Wikipedia,
Benzofuran | C8H1208O – PubChem

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IMMUNOPROTEASOME INHIBITORS

Provided herein are compounds, such as a compound of Formula (I), as described herein, or a pharmaceutically acceptable salt thereof, that are immunoproteasome (such as LMP2 and LMP7) inhibitors. The compounds described herein can be useful for the treatment of diseases treatable by inhibition of immunoproteasomes. Also provided herein are pharmaceutical compositions containing such compounds and processes for preparing such compounds.

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Benzofuran – Wikipedia,
Benzofuran | C8H1153O – PubChem

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Synthesis of enantiomerically enriched (R)- and (S)-benzofuranyl- and benzo[b]thiophenyl-1,2-ethanediols via enantiopure cyanohydrins as intermediates

The chemoenzymatic synthesis of highly enantiopure (R)- and (S)-benzofuranyl- and benzo[b]thiophenyl-cyanohydrins and their chemical transformation into the corresponding heteroaryl-1,2-ethanediols is described.

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Benzofuran – Wikipedia,
Benzofuran | C8H1170O – PubChem