Category: 4687-25-6

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. HPLC of Formula: C9H6O2, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 4687-25-6, name is Benzofuran-3-carbaldehyde. In an article£¬Which mentioned a new discovery about 4687-25-6

Manganese-Catalyzed Ring-Opening Coupling Reactions of Cyclopropanols with Enones

A manganese-catalyzed ring-opening coupling reaction of cyclopropanols with enones for the facile and efficient preparation of 1,6-diketones is described. A wide array of synthetically important 1,6-diketones bearing manifold functional groups are obtained with up to 93% yield. These reactions feature broad substrate scopes, environmentally benign conditions, inexpensive catalyst, and operational simplicity.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 4687-25-6, help many people in the next few years.HPLC of Formula: C9H6O2

Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H1223O – PubChem

Reference of 4687-25-6, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 4687-25-6, molcular formula is C9H6O2, introducing its new discovery.

Photo-bleaching visible light initiator as well as preparation method and application thereof (by machine translation)

The photo initiator of the present invention can successfully initiate visible light free radical photopolymerization, and the polymerization completed material can be converted from colored to colorless transparent, to broaden the use range, of the material and the curing depth of the curing system to be lowered while. The present invention also provides a method, for preparing such a photobleachable visible light initiator by condensation . or, The present invention also provides a method for preparing such a photo-bleached visible light initiator in the visible light curing process. The present invention also provides such a photobleaching visible light initiator . The present invention also provides a method for preparing such a photo-bleached visible light initiator in the visible-light curing process by a condensation reaction of these photoinitiators, in the visible-light-curing field of the present invention and a curing depth thereof is reduced, as shown in FIGS. (by machine translation)

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 4687-25-6 is helpful to your research. Reference of 4687-25-6

Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H1158O – PubChem

4687-25-6, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 4687-25-6, Name is Benzofuran-3-carbaldehyde, molecular formula is C9H6O2. In a Article, authors is Paul, Noel M.£¬once mentioned of 4687-25-6

Structure-activity relationships for a novel series of dopamine D2-like receptor ligands based on N-substituted 3-aryl-8-azabicyclo[3.2.1]octan-3-ol

Discovering dopamine D2-like receptor subtype-selective ligands has been a focus of significant investigation. The D2R-selective antagonist 3-[4-(4-chlorophenyl)-4-hydroxypiperidinyl]methylindole (1, L741,626; K i(D2R/D3R) = 11.2:163 nM) has previously provided a lead template for chemical modification. Herein, analogues have been synthesized where the piperidine was replaced by a tropane ring that reversed the selectivity seen in the parent compound, in human hD2LR- or hD3R-transfected HEK 293 cells (31, Ki(D2R/D3R) = 33.4: 15.5 nM). Further exploration of both N-substituted and aryl ring-substituted analogues resulted in the discovery of several high affinity D2R/D3R ligands with 3-benzofurylmethyl-substituents (e.g., 45, Ki(D2R/D3R) = 1.7:0.34 nM) that induced high affinity not achieved in similarly N-substituted piperidine analogues and significantly (470-fold) improved D3R binding affinity compared to the parent ligand 1. X-ray crystallographic data revealed a distinctive spatial arrangement of pharmacophoric elements in the piperidinol vs tropine analogues, providing clues for the diversity in SAR at the D2 and D3 receptor subtypes.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.4687-25-6. In my other articles, you can also check out more blogs about 4687-25-6

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Benzofuran – Wikipedia,
Benzofuran | C8H1201O – PubChem

4687-25-6, Benzofuran-3-carbaldehyde is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of benzofuran-3-carbaldehyde (5 g, 33.8 mmol) in methanol (50 mL) was cooled with ice and sodium borohydride (1.9 g, 50.7 mmol) was added portionwise. The reaction mixture was stirred at rt for 1 h. The mixture was concentrated and the residue was partitioned between saturated ammonium chloride and DCM. The organic layer was separated, dried over sodium sulfate and concentrated. The crude benzofuran-3-ylmethanol (4.6 g, 92%) was taken as such for next step without further purification.

4687-25-6, As the paragraph descriping shows that 4687-25-6 is playing an increasingly important role.

Reference£º
Patent; PRINCIPIA BIOPHARMA INC.; LOU, Yan; OWENS, Timothy Duncan; BRAMELD, Kenneth Albert; GOLDSTEIN, David Michael; (302 pag.)WO2019/99582; (2019); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4687-25-6,Benzofuran-3-carbaldehyde,as a common compound, the synthetic route is as follows.

General procedure: Titanium tetrachloride (1.90 g, 10 mmol) was slowly added to100 mL of anhydrous THF at 0 ¡ãC, followed by addition of 5 mmol of the aldehyde (1) and stirred for 10 min, then ethyl 2-(3-bromopyridin-2-yl)acetate (2) (1.47 g, 6 mmol) was added. Subsequently, a solution of pyridine (3.16 g, 40 mmol) in 25 mL of anhydrous THF was added dropwise during a period of 30-60 min at 0 ¡ãC. The reaction mixture was then stirred for 1 h at room temperature and refluxed for 24 h. After that the mixture was poured on to crashed ice and extracted with ethyl acetate (4 30 mL). The combined extracts were successively washed with brine, saturated sodium hydrogen carbonate and brine, and then dried over anhydrous MgSO4. The organic phase was filtrated and the solvent was removed in vacuo, the residue was purified by column chromatography (silica gel) using PE/EA (5:1) / DCM/MeOH (50:1) to provide 3.

4687-25-6, As the paragraph descriping shows that 4687-25-6 is playing an increasingly important role.

Reference£º
Article; Li, Bo; Yue, Zhi-Zhou; Feng, Jian-Ming; He, Qian; Miao, Ze-Hong; Yang, Chun-Hao; European Journal of Medicinal Chemistry; vol. 66; (2013); p. 531 – 539;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

4687-25-6, Benzofuran-3-carbaldehyde is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,4687-25-6

General procedure: Using a previously described method,23 a catalytic amount of anhydrous ZnI2 (3.2 mg, 20 mumol) and trimethylsilyl cyanide (119 mg, 1.2 mmol) was added to a stirred solution of one of the aldehydes 1a-d (1 mmol) in dry dichloromethane (10 mL) and the resulting mixture was stirred at room temperature until all of the aldehydes was transformed. The solvent was evaporated and the crude product was redissolved in 10 mL of methanol. The formed trimethylsilyl cyanohydrin decomposed when HCl (3 M, 5 mL) was added. The reaction mass was evaporated to the final volume of 5 mL, after which water (5 mL) and dichloromethane (10 mL) were added. After the separation of the two layers, the aqueous layer was extracted with dichloromethane (2 .x. 10 mL). The combined organic layers were dried over anhydrous Na2SO4 and the solvent was evaporated in vacuo.

As the paragraph descriping shows that 4687-25-6 is playing an increasingly important role.

Reference£º
Article; Naghi, Mara Ana; Bencze, Laszlo Csaba; Brem, Juergen; Paizs, Csaba; Irimie, Florin Dan; Toa, Monica Ioana; Tetrahedron Asymmetry; vol. 23; 2; (2012); p. 181 – 187;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

4687-25-6,4687-25-6, Benzofuran-3-carbaldehyde is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 9Syntheses of N-benzofuran-3-yl-methylidene-N’-(8-morpholin-4-yl-2-pyridin-4-yl-imidazo[1.2-b]pyridazin-6-yl)-hydrazine (Compound 9)6-Chloro-8-morpholin-4-yl-2-pyridin-4-yl-imidazo[1,2-b] pyridazine (65.6mg, 0.208mol) was dissolved in N-methylpyrrolidone (2mL).Potassium carbonate (57.5mg, 0.416mmol) and hydrazine monohydrate (101 muL, 2.08mmol) were added thereto and stirred in a sealed tube at 150¡ãC for 2 hours.Thus obtained reaction liquid was diluted with water and extracted with an ethyl acetate.The extract together with the extraction liquid was dried with anhydrous sodium sulfate, and then the solvent was removed therefrom.The obtained residue was dissolved in ethanol (3mL), and benzofuran-3-carboxyaldehyde (30.4mg, 0.208mmol) was added thereto and stirred at room temperature for 3 hours.Then, the reaction liquid was filtered, and the obtained solid material was washed with diethyl ether to obtain a title compound (37.2mg, 41percent).The characteristic value of the compound is shown below.1H-NMR (300 MHz, DMSO): delta 3.87-3.89 (m, 4H), 3.98-4.00 (m, 4H), 6.50 (s, 1H), 7.40-7.43 (m, 2H), 7.64 (m, 1H), 7.88 (d, 2H, J=6.2 Hz), 8.21-8.24 (m, 2H), 8.37 (s, 1H), 8.57 (d, 2H, J=6.2 Hz), 8.59 (s, 1H), 11.03 (s, 1H); MS (ESI) m/z 440 (M+H)+.

The synthetic route of 4687-25-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; AJINOMOTO CO., INC.; EP2518072; (2012); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem