Category: 4265-25-2

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4265-25-2,2-Methylbenzofuran,as a common compound, the synthetic route is as follows.

1.41 g of potassium hydroxide was sequentially added to a 200 mL autoclave.2.82g 2-methylbenzofuran, 30mL absolute ethanol,18 mg of metalloporphyrin tetrakis (o-chlorophenyl)iron porphyrin,Passing 2.0MPa of oxygen,The reaction was carried out at 130 C for 2 hours.The product is acidified, filtered,After recrystallization from hot water, benzofuran-2-carboxylic acid is obtained.The yield was 21.7%.

4265-25-2, 4265-25-2 2-Methylbenzofuran 20263, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; Beijing University of Technology; Bai Jinquan; Li Xinghua; Wang Sinan; Zhang Yahuan; Xie Yabo; Li Jianrong; (5 pag.)CN109206388; (2019); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

4265-25-2,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4265-25-2,2-Methylbenzofuran,as a common compound, the synthetic route is as follows.

A solution of 16-g (2.89 g, 21.91 mmol) dissolved in tetrahydroffiran (80 mE) was cooled to 5 C., and then N135 (4.68 g, 26.29 mmol) was slowly added thereto. The reactionsolution was reacted at normal temperature overnight, and then poured into sodium thiosulfate solution, and extracted with ethyl acetate (80 mLx3). The combined organic phase was dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluted with petroleum ether) to obtain compound 16-f (2.57 g, yield 56%) as a colourless liquid. ?H NMR (400 MHz, CDC13-MeOD): oe 7.37-7.3 1 (m, 2H), 7.20-7.18 (m, 2H), 2.40 (s, 3H).

4265-25-2 2-Methylbenzofuran 20263, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; SHANGHAI YINGLI PHARMACEUTICAL CO., LTD; XU, Zusheng; (174 pag.)US2016/214994; (2016); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

4265-25-2,4265-25-2, 2-Methylbenzofuran is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of 2-METHYLFURO [3,2-c] pyridine (prepared according to the procedure by T. KITAMURA, K. Tsuda, and Y. FUJIWARA, Tetrahedron Lett. 1998,39, pp. 5375-5376) (26.0 mg, 0.195 mmol) in 2 mL of THF was treated with lithium diisopropylamide (LDA; 1.5 M in cyclohexane, 195 LL) dropwise AT-78 C. The mixture was stirred for 30 minutes (the color changed from yellow to orange-red) and was slowly treated with a solution of 1, 1, 1-TRIFLUORO-4- (5-fluoro-2-methoxyphenyl) -4-methylpentan-2-one (81.5 mg, 0.293 mmol) in 1 mL of THF. The reaction was stirred AT-78 C for 4.5 hours, quenched with 5 mL of saturated ammonium chloride solution, and diluted with 20 mL of ethyl acetate. The phases were separated and the aqueous layer was extracted with three 10 ML portions of ethyl acetate. The combined organic layers were washed with brine, dried over magnesium sulfate, and concentrated in vacuo. Flash chromatography (ethyl acetate-hexanes, 5% to 50% gradient) gave 36.0 mg (45% yield) of the title product as a clear oil.

The synthetic route of 4265-25-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BOEHRINGER INGELHEIM PHARMACEUTICALS, INC.; WO2005/30213; (2005); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem