Properties and Exciting Facts About 2-Methylbenzofuran

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4265-25-2, Name is 2-Methylbenzofuran, belongs to benzofuran compound, is a common compound. Computed Properties of C9H8OIn an article, once mentioned the new application about 4265-25-2.

Ruthenium NHC catalyzed highly asymmetric hydrogenation of benzofurans

H2-O-T! Aromatic O-heterocycles are a challenging substrates for asymmetric hydrogenation (H2). An in situ formed chiral N-heterocyclic carbene (NHC) ruthenium complex allows the high yielding, completely regioselective, and highly asymmetric hydrogenation of substituted benzofurans at room Temperature, giving valuable 2,3-dihydrobenzofurans (see scheme). Copyright

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More research is needed about 2-Methylbenzofuran

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Analytical pyrolysis for determining the molecular composition of contemporary monosulfidic black ooze

On-line flash pyrolysis, micro-scale sealed vessel (MSSV) pyrolysis and catalytic hydropyrolysis (HyPy) were used to characterise the insoluble, macromolecular organic component of monosulfidic black oozes (MBO) which have accumulated within the contemporary eutrophic environment of the Peel-Harvey estuary system (Geographe Bay, Western Australia). Pyrolysates were analysed by gas chromatography-mass spectrometry (GC-MS) and the relative characterisation potential of the three pyrolysis techniques were evaluated with a particular interest in their sensitivity to organic sulfur compounds (OSCs). A similarity of results obtained from three different parts of the ?1 m cores sampled suggests a largely homogenous organic composition throughout the unit. The different pyrolysis techniques did, however, show several notable product differences, particularly the gaseous products detected by the on-line methods of flash- and MSSV-pyrolysis. The very high (i.e., ballistic) heating rate of flash-Py produced very high proportions of gaseous products (e.g., CO 2, H2S and SO2). A strong terrestrially sourced product component was reflected in all three pyrolysates profiles: flash-Py showed relatively high concentrations of lignocellulose products, while MSSV-Py and HyPy produced an abundance of plant wax (>n-C20) n-alkanes. Additionally, quantitatively significant levels (7-14% of total GC product signal) of several higher plant derived terpenoids (e.g., cadalene, p-cymene and calamanene) were identified by MSSV-Py. MSSV-Py also produced far greater overall concentrations of GC-amenable products than flash-Py, including a 14-fold increase of OSCs, which comprised nearly 10% of the total sulfur signal (i.e., organic plus ‘inorganic’ sulfur; cf. 4% of flash pyrolysis). An extended series of alkyl (COA of Formula: C9H8O

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Benzofuran – Wikipedia,
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Extracurricular laboratory:new discovery of 2-Methylbenzofuran

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Recent developments in honey characterization

Honey is a very complex matrix to be investigated. Several chemical classes of compounds are present in a very large range of concentrations. A large number of research groups worldwide have focused their attention and studies to improve the knowledge of honey characterization; it appears clear that new developments of technological improvements would help to provide insight on this complex problem. In the meantime, it is also clear that the officially recognized methodologies are no longer sufficient to answer to the more demanding questions concerning honey authenticity. Complicated and time demanding sample preparation, and the requirement for people specialized in pollen analysis have significantly slowed down analysis response, becoming nowadays unaffordable. The emerging new techniques are opening new frontiers in honey characterization and the most promising approach seems to be the multidisciplinary one, focused on the detection of multiple components, with the aid of chemometrics. In the present review recent findings in honey characterization using advanced analytical techniques such as NMR and Raman spectroscopy, mass spectrometry (MS) also coupled with chromatographic techniques, and other methods are presented covering the period between 2010 and 2015.

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Benzofuran – Wikipedia,
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Environmental factors influencing sorption of heterocyclic aromatic compounds to soil

Heterocyclic organic compounds containing nitrogen, sulfur, or oxygen (NSOs) are an important class of groundwater contaminants related to the production and use of manufactured gas, heavy oils, and coal tar. Surprisingly little is known about the processes that control sorption and transport of NSOs in the subsurface. In this study, the effects of various environmental factors including temperature, ionic strength, and dissolved/sorbed ion composition on the sorption of NSOs have been investigated by means of a soil column chromatography approach. For the investigated compounds, increased temperature normally decreases their sorption to soil. The enthalpy change of the sorption process corroborates earlier findings that van der Waals forces dominate the sorption of S- and O-heterocyclic compounds such as thiophene, benzothiophene, benzofuran, and 2-methylbenzofuran. Ionic strength and ion composition (Ca 2+ vs K+ at given ionic strength) of the aqueous phase show no significant effects on the sorption of these compounds. Previous studies demonstrated that for N-heterocyclic compounds, cation exchange and surface complex formation rather than partitioning into soil organic matter control their overall sorption. In contrast to S- and O-heterocyclic compounds, increasing ionic strength reduced the sorption of ionizable N-heterocyclic compounds (pyridine, 2-methylpyridine, quinoline, 2-methylquinoline, and isoquinoline), due to increased electrostatic competition by cations. At given ionic strength, an increase of the K+/Ca2+ ratio in the mobile phase enhanced the sorption of N-heterocyclic compounds, consistent with cation exchange of the protonated organic species as the dominating sorption process. Among the investigated N-heterocyclic compounds sorption of benzotriazole showed a peculiar feature in that ternary surface complexation with Ca2+ appears to be the dominant sorption mechanism.

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Brief introduction of 2-Methylbenzofuran

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Intramolecular <2 + 2> Cycloaddition Reactions of Ketene and Carbonyl Groups. A New Synthesis of Benzofurans

(o-Carbonylphenoxy)acetyl chlorides are dehydrochlorinated to the corresponding (o-carbonylphenoxy)ketenes which undergo a <2 + 2> cycloaddition reaction to yield tricyclic beta-lactones which spontaneously decarboxylate to benzofurans.

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Benzofuran – Wikipedia,
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Analysis of property variation and stability on the aging of bio-oil from fractional condensation

A series of experiments on bio-oil storage and property measurement were conducted to compare the stability of multi-stage bio-oil from fractional condensation at normal pressure and temperature. The samples from bio-oil stored for 0, 5, 15, 35, 75 days were analyzed for chemical components, moisture, pH and thermophysical properties. During storage, moisture, thermal conductivity, specific heat capacity and viscosity exhibited upward tendencies whereas pH and higher heating value decreased gradually. The properties varied more frequently in the early period of storage due to active components in fresh bio-oil. The relative contents of aliphatic compounds with small molecular weights were significantly reduced after storage but those of phenols were improved slightly. The bio-oil from high condensing temperature showed fewer changes of properties and components during long-term storage. Bio-oil aging was mainly consequent on the reaction of polymerization and oxidation, and results indicated that the bio-oil obtained from 90 C condensing temperature was more appropriate for combustion and processing because of ample high value-added components and stable properties.

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Benzofuran – Wikipedia,
Benzofuran | C8H314O – PubChem

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Synthesis and evaluation of 2-pyridinone derivatives as HIV-1-specific reverse transcriptase inhibitors. 4. 3-[2-(Benzoxazol-2-yl)ethyl]-5-ethyl-6- methylpyridin-2(1H)-one and analogues

A new series of potent specific 2-pyridinone reverse transcriptase (RT) inhibitors was developed based on the preliminary development lead 3- [(phthalimido)ethyl]-5-ethyl-6-methylpyridin-2(1H)-one (3), a non-nucleoside derivative which exhibited weak antiviral activity in cell culture against HIV-1 strain III(B). One compound, 3-[(benzoxazol-2-yl)ethyl]-5-ethyl-6- methylpyridin-2(1H)-one (9,L-696,229), which was a highly selective antagonist of the RT enzyme (IC50 = 23 nM) and which inhibited the spread of HIV-1 III(B) infection by >95% in MT4 human T-lymphoid cell culture (CIC95 = 50-100 nM), was selected for clinical evaluation as an antiviral agent.

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Benzofuran – Wikipedia,
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Discovery of 2-Methylbenzofuran

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HYDROXYL PURINE COMPOUNDS AND USE THEREOF

Disclosed are a series of hydroxyl purine compounds and the use thereof as PDE2 or TNFalpha inhibitors, in particular, the compounds as shown in formula (I), or tautomers thereof or pharmaceutically acceptable salts thereof.

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SELECTIVE PREPARATION AND CYCLIZATION OF 2-(2-HYDROXYPHENYL)-2-(ISOPROPYLTHIO)ETHANOLS. NEW SYNTHESIS OF 1-BENZOFURANS

Reaction of phenols with 2-(isopropylthio)ethyl acetate activated by sulphuryl chloride afforded 2-<2-acetoxy-1-(isopropylthio)ethyl>phenols regioselectively, via <2,3>sigmatropic rearrangement of phenoxysulphonium ylides.The ortho-alkylated phenols thus obtained have been cyclized with conc. hydrochloric acid in 2-methoxyethanol to 1-benzofurans. 2-Methyl- and 2-phenyl-1-benzofurans have been prepared similarly.

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Claisen rearrangement of meta-substituted aryl propargyl ethers in poly(Ethylene glycol)

The thermal rearrangement of meta-substituted aryl propargyl ethers was studied in poly(ethylene glycol)-200. The rearrangement was not regiospecific.

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Benzofuran – Wikipedia,
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