PIM kinase-responsive microsecond-lifetime photoluminescent probes based on selenium-containing heteroaromatic tricycle was written by Ekambaram, Ramesh;Babu Manoharan, Ganesh;Enkvist, Erki;Ligi, Kadri;Knapp, Stefan;Uri, Asko. And the article was included in RSC Advances in 2015.Product Details of 330555-71-0 This article mentions the following:
A new structural fragment was synthesized for construction of protein binding-responsive photoluminescent probes. In complex with protein kinases of the PIM family, bisubstrate inhibitors containing benzo[4,5]seleno[3,2-d]pyrimidin-4-one moiety revealed microsecond-lifetime phosphorescence emission after pulse excitation with near-UV radiation. The phosphorescence signal was substantially (more than 50-fold) amplified by a covalently bound fluorescent dye (PromoFluor-555 or PromoFluor-647) whose absorption spectrum well overlapped with the phosphorescence emission spectrum of the selenium-containing heteroaromatic tricycle. The developed organic small-mol. long-lifetime photoluminescence probes possess subnanomolar affinity towards kinases of the PIM family and reveal especially strong emission signal with PIM-2 isoenzyme. The developed probes have potential to be used for monitoring of activity of PIM kinases for diagnosis of cancer. In the experiment, the researchers used many compounds, for example, Ethyl 3-amino-5-bromobenzofuran-2-carboxylate (cas: 330555-71-0Product Details of 330555-71-0).
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Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem