Downstream synthetic route of 28033-47-8

The synthetic route of 28033-47-8 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.28033-47-8,5-Chlorobenzofuran-2(3H)-one,as a common compound, the synthetic route is as follows.

A. a solution of 47.6 parts by weight of 2-hydroxy-5-chlorophenylacetic acid lactone in 560 parts by volume of glacial acetic acid is treated with 59.2 parts by weight of sodium nitrite at 10C to 20C. The reaction mixture is stirred for 4 hours at 15to 20C and poured into 1700 parts by volume of ice water. The reaction product is collected by filtration, washed with water and dried in vacuo over potassium hydroxide to yield 51.5 parts by weight of 5-chlorocoumaranedione-3-monoxime, m.p. 192C (dec)., 28033-47-8

The synthetic route of 28033-47-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Bayer Aktiengesellschaft; US3993665; (1976); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem