Category: 174775-48-5

More research is needed about Ethyl 5-aminobenzofuran-2-carboxylate

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 174775-48-5. HPLC of Formula: C11H11NO3.

Chemistry, like all the natural sciences, HPLC of Formula: C11H11NO3, begins with the direct observation of nature¡ª in this case, of matter.174775-48-5, Name is Ethyl 5-aminobenzofuran-2-carboxylate, SMILES is O=C(C1=CC2=CC(N)=CC=C2O1)OCC, belongs to benzofurans compound. In a document, author is Zhou, Jiacheng, introduce the new discover.

FeCl2-Catalyzed Direct C-2-Benzylation of Benzofurans with Diarylmethanes via Cross Dehydrogenative Coupling

A direct strategy for the iron-catalyzed oxidative coupling C-2-functionalization of benzofurans with unactivated diarylmethanes has been established. The developed procedure provides a straightforward access to C-2-benzylation of benzofurans from simple and abundant starting materials without the need for pre-functionalization or specific substituted functional groups of both, substrates and coupling partners.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 174775-48-5. HPLC of Formula: C11H11NO3.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Simple exploration of 174775-48-5

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 174775-48-5. Formula: C11H11NO3.

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Formula: C11H11NO3, 174775-48-5, Name is Ethyl 5-aminobenzofuran-2-carboxylate, SMILES is O=C(C1=CC2=CC(N)=CC=C2O1)OCC, belongs to benzofurans compound. In a document, author is Assiri, Mohammed M., introduce the new discover.

The Chemical Behavior of (2E)-3-(4,9-Dimethoxy-5-Oxo-5H-Furo[3,2-g] Chromen-6-yl)Acrylonitrile Towards Some Carbon Nucleophiles

Some novel substituted benzofurans and annulated furochromenes were obtained through the treatment of the novel (2E)-3-(4,9-dimethoxy-5-oxo-5H-furo[3,2-g]chromen-6-yl)acrylonitrile (2) by some active carbon nucleophiles such as active methylene ketones and methylene nitriles. Thus, the reaction of acrylonitrile 2 with acetylacetone, ethyl acetoacetate, diethylmalonate, and acetoacetanilide in ethanol containing piperidine produced efficiently the corresponding polyfunctionalized benzonitrile derivatives 3?5 and furochromeno-pyridine 6, respectively. Also, treatment of acrylonitrile 2 with some methylene nitriles such as malononitrile, ethyl cyanoacetate, and malononitrile dimer afforded the annulated furochromene derivatives 7?9. Furthermore, the pyrido[1,2-a] benzimidazole system 10 was furnished via reaction of acrylonitrile 2 with 2-(1?H-benzimidazol-2-yl)acetonitrile. These reactions took place through Michael addition, retro-Michael, and ?-pyrone ring opening followed by different types of recyclization. The chemical structures of the novel products were established on the basis of their spectral data and elemental analysis.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 174775-48-5. Formula: C11H11NO3.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Some tips on 174775-48-5

As the paragraph descriping shows that 174775-48-5 is playing an increasingly important role.

174775-48-5, Ethyl 5-aminobenzofuran-2-carboxylate is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Commercially available ethyl 5-NITROBENZOFURAN-2-CARBOXYLATE 30 was HYDROGENATED on PD-C and ACYLATED using commercially available 4-NITRO-N-METHYL-2- TRICHLOROACETYL-PYRROLE 32 to form 33. HYDROGENATION of 33 followed by acylation with 32 afforded the nitro compound 35, which upon HYDROGENATION yielded 36 as the amino compound. ACETYLATION of the amino group of 36 followed by base catalyzed hydrolysis resulted in the acid 37. Coupling of 37 with the hydrochloride salt 39 (obtained by DEPROTECTION of the BOC derivative 38) using EDC afforded the ester 40. See Figure 4., 174775-48-5

As the paragraph descriping shows that 174775-48-5 is playing an increasingly important role.

Reference£º
Patent; THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES; WO2005/32594; (2005); A2;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

Downstream synthetic route of 174775-48-5

The synthetic route of 174775-48-5 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.174775-48-5,Ethyl 5-aminobenzofuran-2-carboxylate,as a common compound, the synthetic route is as follows.

To the solution of ethyl 5-aminobenzofuran-2-carboxylate (4) (1 mmol), bis-(2-chloro ethyl) amine (1.5 mmol), and sodium carbonate (2.0 mmol), in 1-propanol solvent. Reaction mass is heat to reflux for 24 h and filtered. Add mixture of water and MDC. Extract the compound with MDC twice. The combined organic layer was dried over Na2SO4 and then evaporated to dryness. Compound purified by column chromatography. 35% yield. Get the ethyl-5-(1-piperazinyl) benzofuran-2-carboxylate. White solid, 89% yield, mp 269.4-271.4 C, 1H NMR (300 MHz, CDCl3): delta = 7.68 (s, 1H), 7.36 (m, 1H), 6.84 (m, 2H), 4.35 (q, J = 7.5, 14.4 Hz, 2H), 3.89 (t, J = 4.4 Hz, 4H), 3.15 (t, J = 4.8 Hz, 4H), 1.33 (m, 3H) 6H); 13C NMR (75 MHz, DMSO+CDCl3): 157.3, 154.9, 142.5, 129.7, 120.8, 112.2, 110.4, 109.2, 107.2, 58.8, 59.2, 49.8, 48.2, 43.4, 13.2. MS calcd for C19H23N3O4: 357.4. Found: 358.6, (M+). Anal. Calcd for C19H23N3O4: C, 63.85; H, 6.49; N, 11.76. Found: C, 63.82; H, 6.48; N, 11.78., 174775-48-5

The synthetic route of 174775-48-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Renuka, Janupally; Reddy, Kummetha Indrasena; Srihari, Konduri; Jeankumar, Variam Ullas; Shravan, Morla; Sridevi, Jonnalagadda Padma; Yogeeswari, Perumal; Babu, Kondra Sudhakar; Sriram, Dharmarajan; Bioorganic and Medicinal Chemistry; vol. 22; 17; (2014); p. 4924 – 4934;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

Brief introduction of 174775-48-5

Big data shows that 174775-48-5 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.174775-48-5,Ethyl 5-aminobenzofuran-2-carboxylate,as a common compound, the synthetic route is as follows.

Example-4: preparation of ethyl 5-(l-piperazinyl)-benzofuran-2-carboxylate hydrobromide. ethyl-5 -amino- l-benzofuran-2-carboxylate obtained in above step was dissolved in o-Xylene (1500ml) and then Bis (2-chloroethyl) amine hydrochloride (1 13.8g), Potassium carbonate powder (108.6g) and TBAB (5.0g) at 20-30C was added in the reaction mixture. The reaction mixture was maintained for 32 hrs at 135-140C. After completion of the reaction solid was filtered and washed it with o-Xylene [100ml *3], suck it dry. The wet cake was charged in the saturated brine solution under stirring and ammonia solution (100ml) was added in the reaction mixture at 10- 15C under stirring. The product was extracted in MDC (1000ml) and washed subsequently with dilute acetic acid and water. Aqueous HBr was charged in MDC layer and then MDC was removed atmospherically up-to 50C. Ethanol (700ml) was charged to the residue and raise the temperature of the suspension to 55-60C. The reaction mass was cooled for 1-2 hours at 20-30C and filtered the solid, washed it with Ethanol [100ml x3]. Dried at 55-60C for 12 hours. Yield: 81.3%, 174775-48-5

Big data shows that 174775-48-5 is playing an increasingly important role.

Reference£º
Patent; ALEMBIC PHARMACEUTICALS LIMITED; JAYARAMAN, Venkat Raman; RATHOD, Dhiraj; VOHRA, Irfan; BHUJADE, Vinayak; MODI, Viral; GANDHI, Ojas; BUDH, Mayur; WO2013/153492; (2013); A2;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

Downstream synthetic route of 174775-48-5

The synthetic route of 174775-48-5 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.174775-48-5,Ethyl 5-aminobenzofuran-2-carboxylate,as a common compound, the synthetic route is as follows.

General procedure: To a stirred solution of 1-(2,3-dichlorophenyl) piperazine (entry 3) (5 g, 0.022 mol) in THF (25 mL) was added formamide (2.4 g, 0.054 mol).To the above mixture was added sodium methoxide (30% solution in methanol, 9.7 g, 0.054 mol) and stirred at room temperature for 6 h. The solvent was evaporated and the reaction mixture was diluted with water and extracted with dichloromethane (50 mL ¡Á 2). The dichloromethane layer was washed with 25 mL of dilute HCl and concentrated under reduced pressure to give the product (5.1 g, 92%)., 174775-48-5

The synthetic route of 174775-48-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Joseph, Sony; Das, Prasenjit; Srivastava, Bindu; Nizar, Hashim; Prasad, Mohan; Tetrahedron Letters; vol. 54; 8; (2013); p. 929 – 931;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

Analyzing the synthesis route of 174775-48-5

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174775-48-5, Ethyl 5-aminobenzofuran-2-carboxylate is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: An oven-dried Schlenk tube (A) equipped with a magnetic stir bar was charged with AgF (132.2 mg, 1.05 mmol, 3.5 equiv), sealed with a septum, and degassed by alternating vacuum evacuation and nitrogen backfill (three times) before freshly distilled EtCN (3 mL)was added. To the resulting suspension, which was precooled to -78 C (dry ice-acetone bath), was added TMSCF3 (149.3 mg, 1.05 mmol, 3.5 equiv) by microsyringe. The mixture was allowed towarm to r.t. and stirring was continued for an additional 15 min. In due course, AgF solid dissolved and a gray, dark solution of [Ag-CF3] formed. Another Schlenk tube (B) equipped with a magnetic stir bar was charged with the aniline (ArNH2; 0.30 mmol, 1.0 equiv) in freshly distilled EtCN (1.5 mL). To the resulting solution, which was precooled to 0 C (ice bath), aq HCl (12 M; 50.0 muL, 0.60mmol, 2.0 equiv) was added; precipitate formed immediately. After 5 min stirring, t-BuONO (37.7 mg, 0.33 mmol, 1.1 equiv) was added by microsyringe, and the mixture was allowed to stir at 0 C for 15 min. The resulting suspension in Schlenk tube (B) was degassed by alternating vacuum evacuation at -196 C (liquid nitrogen), then the solution was allowed to warm to r.t. under a nitrogen atmosphere (three times), and finally cooled to -78 C (dry ice-acetone bath). The gray, dark solution of [AgCF3] in Schlenk tube (A), which was precooled to -78 C (dry ice-acetone bath), was added to Schlenk tube (B) (ArN2+Cl-) by syringe at -78 C (dry ice-acetone bath) over a period of 1 h. After the addition was complete, the reaction mixture was stirred for 3 h at -78 C (dry ice-acetone bath), allowed to warm to r.t., and stirring was continued for an additional 1 h. An off-white precipitate was observed, and the reaction mixture was diluted with EtOAc (3 mL) and filtered through a short silica gel column. The solvent was removed under reduced pressure with a rotatory evaporator, and the crude residue was purified by silica gel column chromatography to give the desired trifluoromethylation product 3. The yields of products 3a, 3f, 3g, 3l, 3o, 3r, 3x, and 3zb are based on the 19F NMR spectra with 4-F3COC6H4OMe as internal standard. Analytical data for the representative product ethyl 4-(trifluoromethyl)benzoate (3i) are provided below. Data for other products can be found in the literature.

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Reference£º
Article; Wang, Xi; Xu, Yan; Zhou, Yujing; Zhang, Yan; Wang, Jianbo; Synthesis; vol. 46; 16; (2014); p. 2143 – 2148;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem