Category: 1646-27-1

One-pot synthesis of 2-aryl-3-alkoxycarbonyl chromones through a cascade Lewis acid-catalyzed aldehyde olefination/oxa-Michael addition/oxidation was written by Wang, Ningning;Cai, Shuying;Zhou, Chao;Lu, Ping;Wang, Yanguang. And the article was included in Tetrahedron in 2013.Computed Properties of C10H8O3 This article mentions the following:

2-Aryl-3-alkoxycarbonyl chromones were effectively constructed from aryl aldehydes and 3-(2-(methoxymethoxy)phenyl)propiolates via a cascade Lewis acid catalyzed phenol ether deprotection/aldehyde olefination/intramol. oxa-Michael addition reaction, and a sequential oxidation This four-step reaction could be conducted in one-pot with high atom efficiency. In the experiment, the researchers used many compounds, for example, Methyl benzofuran-2-carboxylate (cas: 1646-27-1Computed Properties of C10H8O3).

Methyl benzofuran-2-carboxylate (cas: 1646-27-1) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.Computed Properties of C10H8O3

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Benzofuran derivatives. XVI. Infrared spectra of coumarilic acid esters was written by Goldenberg, C.;Binon, F.. And the article was included in Bulletin des Societes Chimiques Belges in 1966.Electric Literature of C10H8O3 This article mentions the following:

The ir spectra of coumarilic acid esters in CS₂ showed 2 peaks in the carbonyl stretching region. Exptl. it was proved that this splitting was not due to a Fermi resonance or to the existence of dimers. The splitting was ascribed to the link XCCOOR(X = O or N) in a cyclic or acyclic structure, in which 2 rotational isomers were present in equilibrium In the experiment, the researchers used many compounds, for example, Methyl benzofuran-2-carboxylate (cas: 1646-27-1Electric Literature of C10H8O3).

Methyl benzofuran-2-carboxylate (cas: 1646-27-1) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Electric Literature of C10H8O3

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Accepting the Invitation to Open Innovation in Malaria Drug Discovery: Synthesis, Biological Evaluation, and Investigation on the Structure-Activity Relationships of Benzo[b]thiophene-2-carboxamides as Antimalarial Agents was written by Pieroni, Marco;Azzali, Elisa;Basilico, Nicoletta;Parapini, Silvia;Zolkiewski, Michal;Beato, Claudia;Annunziato, Giannamaria;Bruno, Agostino;Vacondio, Federica;Costantino, Gabriele. And the article was included in Journal of Medicinal Chemistry in 2017.Recommanded Product: 1646-27-1 This article mentions the following:

Malaria eradication is a global health priority, but current therapies are not always suitable for providing a radical cure. Artemisinin has paved the way for the current malaria treatment, the so-called Artemisinin-based Combination Therapy (ACT). However, with the detection of resistance to ACT, innovative compounds active against multiple parasite species and at multiple life stages are needed. GlaxoSmithKline has recently disclosed the results of a phenotypic screening of an internal library, publishing a collection of 400 antimalarial chemotypes, termed the “Malaria Box”. After anal. of the data set, we have carried out a medicinal chem. campaign in order to define the structure-activity relationships for one of the released compounds, which embodies a benzothiophene-2-carboxamide core. Thirty-five compounds were prepared, and a description of the structural features responsible for the in vitro activity against different strains of P. falciparum, the toxicity, and the metabolic stability is herein reported. In the experiment, the researchers used many compounds, for example, Methyl benzofuran-2-carboxylate (cas: 1646-27-1Recommanded Product: 1646-27-1).

Methyl benzofuran-2-carboxylate (cas: 1646-27-1) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Recommanded Product: 1646-27-1

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Direct Alkoxycarbonylation of Heteroarenes via Cu-Mediated Trichloromethylation and In Situ Alcoholysis was written by Luo, Wenkun;Jiang, Kai;Li, Yingwei;Jiang, Huanfeng;Yin, Biaolin. And the article was included in Organic Letters in 2020.SDS of cas: 1646-27-1 This article mentions the following:

An efficient approach for direct alkoxycarbonylation of furans I (R¹ = iso-Pr, cyclopentyl, benzyl, etc.) as well as other heteroarenes, e.g., thiazole via a one-step copper-mediated reaction of three components (i.e., heteroarene, alc., and CHCl₃) was reported. The copper additive was confirmed to simultaneously promote the reaction in three pathways: oxidant cracking, single electron transfer, and alcoholysis. By means of this protocol, various functionalized furancarboxylates II (R² = Me, cyclopentyl, etc) and other heteroarenecarboxylates, e.g., Me benzo[d]thiazole-2-carboxylate were facilely obtained in moderate to good yields. In the experiment, the researchers used many compounds, for example, Methyl benzofuran-2-carboxylate (cas: 1646-27-1SDS of cas: 1646-27-1).

Methyl benzofuran-2-carboxylate (cas: 1646-27-1) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.SDS of cas: 1646-27-1

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Preparation and reactions of a benzofurylmercuric compound was written by Izumi, Taeko;Takeda, Toru;Kasahara, Akira. And the article was included in Yamagata Daigaku Kiyo, Kogaku in 1974.Synthetic Route of C10H8O3 This article mentions the following:

2-Benzofurylmercuric chloride (I) was obtained by the reaction of benzofuran (II), 1 equivalent HgCl2, and 2 equivalentsNaOAc. 3H2O in aqueous EtOH at room temperature 5 days; m.p. 274-8°. I was also prepared by the reaction of Na coumarylate with an equivalent amount of HgCl2 in 1 l. water followed by decarboxylation under gentle reflux. Benzofurylation of olefins such as styrene, Et acrylate, Et crotonate, and H2C:CHCN were performed in the presence of Li2PdCl4 in MeOH or MeCN, accompanied by the formation of 2,2′-dibenzofuran (III). Carbonylation of I at 100° 6 hr under 50 atm CO pressure in the presence of Li2PdCl4 in MeOH gave Me coumarylate, 2,2′-dibenzofuryl ketone, and a small amount of III. 2-Acetylation and benzoylation of I with acyl chlorides, coupling reaction to 2,2′-dibenzofurylmercury by Na2S2O3, and 2-bromination with Br were reported. In the experiment, the researchers used many compounds, for example, Methyl benzofuran-2-carboxylate (cas: 1646-27-1Synthetic Route of C10H8O3).

Methyl benzofuran-2-carboxylate (cas: 1646-27-1) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Synthetic Route of C10H8O3

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Visible-Light-Induced Direct Photocatalytic Carboxylation of Indoles with CBr₄/MeOH was written by Yang, Qing-Qing;Marchini, Marianna;Xiao, Wen-Jing;Ceroni, Paola;Bandini, Marco. And the article was included in Chemistry – A European Journal in 2015.Application In Synthesis of Methyl benzofuran-2-carboxylate This article mentions the following:

Photocatalysis enables the cascade reactions of indoles and CBr₄ in MeOH through a C(sp²)-H functionalization/methanolysis sequence. The title reaction provides an efficient access to indole-2- and 3-carboxylates in a single operation (no preinstallation of protecting or directing groups was required) with good yields under mild reaction conditions. In the experiment, the researchers used many compounds, for example, Methyl benzofuran-2-carboxylate (cas: 1646-27-1Application In Synthesis of Methyl benzofuran-2-carboxylate).

Methyl benzofuran-2-carboxylate (cas: 1646-27-1) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.Application In Synthesis of Methyl benzofuran-2-carboxylate

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Design, synthesis and evaluation of benzoheterocycle analogues as potent antifungal agents targeting CYP51 was written by Zhao, Shizhen;Wei, Peng;Wu, Mengya;Zhang, Xiangqian;Zhao, Liyu;Jiang, Xiaolin;Hao, Chenzhou;Su, Xin;Zhao, Dongmei;Cheng, Maosheng. And the article was included in Bioorganic & Medicinal Chemistry in 2018.Recommanded Product: 1646-27-1 This article mentions the following:

To further enhance the anti-Aspergillus efficacy of the previously discovered antifungal lead compound, a series of benzoheterocycle analogs were designed, synthesized and evaluated for their in vitro antifungal activity. The most promising compounds I and II exhibited excellent antifungal activity against C. albicans, C. neoformans, A. fumigatus and fluconazole-resistant C. albicans strains, that was superior or comparable to those of the reference drugs fluconazole and voriconazole. GC-MS analyses suggested that the novel compound I might have a similar mechanism to fluconazole by inhibiting fungal lanosterol 14α-demethylase (CYP51). Furthermore, compounds I and II exhibited low inhibition profiles for various human cytochrome P 450 isoforms as well as excellent blood plasma stability. In the experiment, the researchers used many compounds, for example, Methyl benzofuran-2-carboxylate (cas: 1646-27-1Recommanded Product: 1646-27-1).

Methyl benzofuran-2-carboxylate (cas: 1646-27-1) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.Recommanded Product: 1646-27-1

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem