Category: 15832-09-4

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The synthetic route of 15832-09-4 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.15832-09-4,6-Methoxy-3(2H)-benzofuranone,as a common compound, the synthetic route is as follows.

To a solution of 2-12 (450 mg, 2.74 mmol) in anhydrous acetic acid (4.9 ml/mmol) was added the 3-chloro-4-hydroxybenzaldehyde (2.74 mmol), followed by dropwise addition of concentrated HCl (0.3 ml/mmol). The reaction mixture was stirred at room temperature for 2 h. The reaction mixture was diluted with distilled water (100 ml) and stirred for 15 min. The precipitate formed was filtered under suction to yield aurone 6-12 which was used without further purification, yellow solid, yield 91.6%. M.p. 210-212 C, 1H NMR (DMSO-d6, 500 MHz): delta 8.0 (d,J 2 Hz, 1H), d 7.79 (dd, J1 2 Hz, J2 8.6 Hz, 1H), 7.68 (d,J 8.6 Hz, 1H), 7.17 (d, J 2 Hz, 1H), 7.08 (d, J 8.5 Hz, 1H), 6.85 (dd,J1 2.1, J2 8.5 Hz, 1H), 6.79 (s, 1H), 3.93 (s, 3H).

The synthetic route of 15832-09-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Liew, Kok-Fui; Chan, Kit-Lam; Lee, Chong-Yew; European Journal of Medicinal Chemistry; vol. 94; (2015); p. 195 – 210;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

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15832-09-4 6-Methoxy-3(2H)-benzofuranone 585368, abenzofuran compound, is more and more widely used in various.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.15832-09-4,6-Methoxy-3(2H)-benzofuranone,as a common compound, the synthetic route is as follows.

To a solution of 6-methoxybenzofuran-3(2H)-one (58?mg, 0.354?mmol) in MeOH (5?mL) were added an aqueous solution of KOH (50%, 0.30?mL) and 3,4-dimethoxybenzaldehyde (59?mg, 0.354?mmol), and the mixture was stirred at room temperature for 2?h. The solid was then filtered, washed with cold MeOH and dried. The crude product was recrystallized from MeOH to afford 34 (25?mg, 23%) as a yellow solid. 1H NMR (CDCl3) delta 7.72 (d, 1H, J?=?8.3?Hz), 7.51 (d, 1H, J?=?1.9?Hz), 7.48 (dd, 1H, J1?=?8.3?Hz, J2?=?1.9?Hz), 6.94 (d, 1H, J?=?8.3?Hz), 6.80 (s, 1H), 6.77 (dd, 1H, J1?=?8.3?Hz, J2?=?2.1?Hz), 6.76 (s, 1H), 3.99 (s, 3H), 3.95 (s, 3H), 3.94 (s, 3H). 13C NMR (CDCl3) delta 183.0, 168.4, 167.4, 150.8, 149.2, 147.0, 126.0, 125.9, 125.6, 115.3, 113.9, 112.6, 112.2, 111.4, 96.8, 56.3, 56.2, 56.2. IR (ATR) upsilon 1596, 1516, 1442, 1424, 1292, 1283, 1261, 1169, 1145, 1122, 1091, 1043, 1015, 949, 896, 862, 835, 816, 771, 700?cm-1. HRMS (ESI) calc. for C18H17O5 [M + H]+ 313.1071, found 313.1065.

15832-09-4 6-Methoxy-3(2H)-benzofuranone 585368, abenzofuran compound, is more and more widely used in various.

Reference£º
Article; Olleik, Hamza; Yahiaoui, Samir; Roulier, Brayan; Courvoisier-Dezord, Elise; Perrier, Josette; Peres, Basile; Hijazi, Akram; Baydoun, Elias; Raymond, Josette; Boumendjel, Ahcene; Maresca, Marc; Haudecoeur, Romain; European Journal of Medicinal Chemistry; vol. 165; (2019); p. 133 – 141;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem