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Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. Computed Properties of C10H12O2. Introducing a new discovery about 1563-38-8, Name is 2,2-Dimethyl-2,3-dihydrobenzofuran-7-ol

N – [(dihydrobenzofuran -7 – oxy) alkyl] -2 – aryloxy amide derivatives (by machine translation)

The invention discloses a such as chemical structural formula I and II shown in the N – [(dihydrobenzofuran – 7 – yloxy) alkyl] – 2 – aryloxy amide derivatives: Wherein R is selected from: hydrogen, C1 – C2 Alkyl, C3 – C4 C straight chain alkyl or3 – C4 Branched alkyl; n selected from: 1, 2, 3, 4, 5, 6; Y1 Is selected from: hydrogen, C1 – C2 Alkyl, fluorine, chlorine, bromine or iodine; Y2 Is selected from: hydrogen, C1 – C2 Alkyl, fluoro, chloro, bromo, iodo, trifluoromethyl or trifluoroethyl; Y3 Is selected from: hydrogen, C1 – C2 Alkyl, fluorine, chlorine, bromine or iodine. N – [(dihydrobenzofuran -7 – oxy) alkyl] -2 – aryloxy amide derivatives for the preparation of herbicide in the application. (by machine translation)

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Benzofuran – Wikipedia,
Benzofuran | C8H2302O – PubChem

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Furan and chroman wowo alkene/propargylether and its preparation method and application (by machine translation)

The invention relates to furan chroman oxime alkene/propargyl ether shown in the chemical structural formula I/II (please see the formula in the specification). R in the formula is selected from hydrogen, C1-C2 alkyl groups, and C3-C4 straight chain or C3-C4 branched chain alkyl groups. The furan chroman oxime alkene/propargyl ether is used in preparation of sterilizing agents.

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Benzofuran – Wikipedia,
Benzofuran | C8H2306O – PubChem

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2-Phenylaminonaphthoquinones and related compounds: Synthesis, trypanocidal and cytotoxic activities

A series of new 2-aminonaphthoquinones and related compounds were synthesized and evaluated in vitro as trypanocidal and cytotoxic agents. Some tested compounds inhibited epimastigote growth and trypomastigote viability. Several compounds showed similar or higher activity and selectivity as compared with current trypanocidal drug, nifurtimox. Compound 4l exhibit higher selectivity than nifurtimox against Trypanosoma cruzi in comparison with Vero cells. Some of the synthesized quinones were tested against cancer cells and normal fibroblasts, showing that certain chemical modifications on the naphthoquinone moiety induce and excellent increase the selectivity index of the cytotoxicity (4g and 10). The results presented here show that the anti-T. cruzi activity of 2-aminonaphthoquinones derivatives can be improved by the replacement of the benzene ring by a pyridine moiety. Interestingly, the presence of a chlorine atom at C-3 and a highly lipophilic alkyl group or aromatic ring are newly observed elements that should lead to the discovery of more selective cytotoxic and trypanocidal compounds.

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Benzofuran – Wikipedia,
Benzofuran | C8H2412O – PubChem

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Scaffold hopping of sampangine: Discovery of potent antifungal lead compound against Aspergillus fumigatus and Cryptococcus neoformans

Discovery of novel antifungal agents against Aspergillus fumigatus and Cryptococcus neoformans remains a significant challenge in current antifungal therapy. Herein the antifungal natural product sampangine was used as the lead compound for novel antifungal drug discovery. A series of D-ring scaffold hopping derivatives were designed and synthesized to improve antifungal activity and water solubility. Among them, the thiophene derivative S2 showed broad-spectrum antifungal activity, particularly for Aspergillus fumigatus and Cryptococcus neoformans. Moreover, compound S2 also revealed better water solubility than sampangine, which represents a promising antifungal lead compound for further structural optimization.

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Benzofuran – Wikipedia,
Benzofuran | C8H2369O – PubChem

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Synthesis and antiprotozoal activity of naphthofuranquinones and naphthothiophenequinones containing a fused thiazole ring

The synthesis of tetracyclic quinones 10a,b, 14a,b, 19a,b and 20a,b is described. The preparations involve regioselective Diels-Alder reactions via trapping the thiazole o-quinodimethane 9 with several benzofuranquinones and benzothiophenequinones. The structure of the regioisomers was assigned through 2D NMR 1H-13C HMBC experiments performed on 10a and 14a. Compounds 10a,b, 14a as well as phenol 1 and the starting quinones 2, 5, 7 and 15 are evaluated against Leishmania sp., Toxoplasma gondii and THP-1 cells. Almost all the tested compounds exhibit significant antiprotozoal activities with lower cytotoxicities than the reference compounds. Among them, quinones 2 and 14a possess the best activities towards L. donovani and T. gondii with the lowest toxicities.

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Benzofuran – Wikipedia,
Benzofuran | C8H2421O – PubChem

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Application of 1563-38-8, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.1563-38-8, Name is 2,2-Dimethyl-2,3-dihydrobenzofuran-7-ol, molecular formula is C10H12O2. In a Article£¬once mentioned of 1563-38-8

Is intraspecies QSTR model answer to toxicity data gap filling: Ecotoxicity modeling of chemicals to avian species

Interspecies model represents an established approach for the response data gap filling for regulatory agencies and researchers. We propose a novel approach of intraspecies modeling within the animals of the same species, instead of animals from different species. The proposed intraspecies model is capable of more precise extrapolation of data than the interspecies model, as animals under the same species share a similar mechanism of action (MOA) and target sites for the response. Along with the advantage of better prediction over the interspecies model, the intraspecies model has all the significant features like recognition of MOA, species-specific toxicity, reduction of animal experimentation, and money and time. To establish and test the intraspecies modeling approach, we have modeled ecotoxicity of organic chemicals to three avian species: Anas platyrhynchos, Colinus virginianus, and Phasianus colchicus. The intraspecies models offer to identify the mechanistic interpretation of the ecotoxicity of the studied chemicals along with the toxicity data gap filling. The success of the intraspecies modeling relies on connecting the missing dots of toxicity for the regulatory purposes, especially when there is a scarcity of ecotoxicity experimental data and in silico models for avian species.

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Benzofuran – Wikipedia,
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Partial degradation of carbofuran by natural pyrite

This work provides new insight into the degradation of 2,2-dimethyl-2,3-dihydrobenzofuran-7-yl-methylcarbamate (hereafter carbofuran) by natural pyrite as a function of pH and adsorbent loading. In the presence of tert-butyl alcohol i.e., OH scavenger, the degradation efficiency of carbofuran was almost stopped. In acidic solutions (pH < 5) the degradation kinetics was pseudo first order in carbofuran as -d[carbofuran]dt=-kobserved¡Á[carbofuran]. The dependence of kobserved on [FeS2] was given as kobserved = k0 + [FeS2] ¡Á k1 where k0 = 1.16 ¡Á 10-7 h-1 and k1 = 0.137 h-1. The elucidation of precise steps of carbofuran degradation by pyrite has yet to be solved. I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 1563-38-8, help many people in the next few years.COA of Formula: C10H12O2

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Benzofuran – Wikipedia,
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Carbofuran Degradation by Biogenic Manganese Oxides

This work studied the effect of biogenic manganese oxides (Bio-MnOx) on carbofuran degradation.The results showed that 21.05 % and 90.63 % carbofuran, respectively, were degraded in 4 days by Bio-MnOx with and without NaN3 at initial pH 4.80, whereas carbofuran was hardly degraded by chemical manganese oxides in the same condition. Bio-MnOx promoted carbofuran hydrolysis by changing the pH of the environment and encouraged carbofuran phenol cleavage by its oxidization. Both the oxidation of carbofuran phenol by Bio-MnOx and the reoxidation of the released Mn(II) by Mn(II)-oxidizing microorganisms ensured the continuous reactivity of Bio-MnOx and prevented the secondary pollution of Mn(II). Carbofuran phenol was the major transformation product in the degradation and was further oxidized into small organic molecules as monitored by a GC/MS analyzer. This report offers an efficient, feasible, and no-secondary-pollution approach to controlling carbofuran pollution.

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Benzofuran – Wikipedia,
Benzofuran | C8H2385O – PubChem

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Hydrolase CehA and monooxygenase CfdC are responsible for carbofuran degradation in Sphingomonas sp. strain CDS-1

Carbofuran, a broad-spectrum systemic insecticide, has been extensively used for approximately 50 years. Diverse carbofuran-degrading bacteria have been described, among which sphingomonads have exhibited an extraordinary ability to catabolize carbofuran; other bacteria can only convert carbofuran to carbofuran phenol, while all carbofuran-degrading sphingomonads can degrade both carbofuran and carbofuran phenol. However, the genetic basis of carbofuran catabolism in sphingomonads has not been well elucidated. In this work, we sequenced the draft genome of Sphingomonas sp. strain CDS-1 that can transform both carbofuran and carbofuran phenol but fails to grow on them. On the basis of the hypothesis that the genes involved in carbofuran catabolism are highly conserved among carbofurandegrading sphingomonads, two such genes, cehACDS-1 and cfdCCDS-1, were predicted from the 84 open reading frames (ORFs) that share ?95% nucleic acid similarities between strain CDS-1 and another sphingomonad Novosphingobium sp. strain KN65.2 that is able to mineralize the benzene ring of carbofuran. The results of the gene knockout, genetic complementation, heterologous expression, and enzymatic experiments reveal that cehACDS-1 and cfdCCDS-1 are responsible for the conversion of carbofuran and carbofuran phenol, respectively, in strain CDS-1. CehACDS-1 hydrolyzes carbofuran to carbofuran phenol. CfdCCDS-1, a reduced flavin mononucleotide (FMNH2)- or reduced flavin adenine dinucleotide (FADH2)-dependent monooxygenase, hydroxylates carbofuran phenol at the benzene ring in the presence of NADH, FMN/FAD, and the reductase CfdX. It is worth noting that we found that carbaryl hydrolase CehAAC100, which was previously demonstrated to have no activity toward carbofuran, can actually convert carbofuran to carbofuran phenol, albeit with very low activity.

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Benzofuran – Wikipedia,
Benzofuran | C8H2433O – PubChem

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Syntheses and crystal structure of lithium, zinc and sodium 2,3-dihydro-2,2-dimethyl-7-benzofuranoxide aggregates

The synthesis, characterization and the X-ray structure of the three title complexes containing the 2,3-dihydro-2,2-dimethyl-7-benzofuranoxide (ddbfo) ligand are reported. The structure of [Li4Zn(mu3,eta2- ddbfo)2(mu,eta2-ddbfo)3Cl(CH3CN)2] includes four lithium and one zinc tetrahedral metal centers linked by mu-O(aryloxide) and mu3- O(aryloxide) bridges. The crystals of [Na4([mu3,eta2-ddbfo)4(CH3CN)4] are composed of centrosymmetric cubic molecules. The crystal structure determination of compound [Zn2(mu,eta1-ddbfo)2Cl2(py)2] shows it to be a centrosymmetric dimer, in which two ZnCl(py) units are linked by mu-O(aryloxide) oxygen atoms of eta1-ddbfo ligands.

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Benzofuran – Wikipedia,
Benzofuran | C8H2415O – PubChem