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The chemical composition of root and rhizosphere soil extracts of plant of Tagetes patula L. was investigated by GC-MS for the identification of allelochemicals. The dried and powdered root material was subjected to Soxhlet extraction using methanol. The rhizosphere soil around the plant was also extracted with methanol. GC-MS analysis of the roots and rhizosphere soil extracts led to identification of 25 and 27 compounds, respectively. The major compounds identified in methanol root extract were 5-hydroxymethylfurfural (21.81 %), butanoic acid, 2,2-dimethyl-3-oxo-methyl ester (11.71 %), 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one (12.68 %), 5-(4-acetoxy- 1-butynyl)-2,2?-bithienyl (8.50 %). However in rhizosphere soil extract dimethylsulfoxonium formylmethylide (6.32 %), 2-phenylthieno[2,3-b]thiophene (9.34 %), hexadecanoic acid (16.64 %), alpha-terthienyl (5.81 %), stigmasterol (5.32 %), gamma-sitosterol (5.71 %) were present as major compounds.

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Benzofuran – Wikipedia,
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N-heterocyclic moiety-containing hydroxyethylamine protease inhibitor compounds, methods for making the compounds, and intermediates useful in the method. Also, a method for inhibiting retroviral proteases and for treatment or prophylaxis of a retroviral infection.

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Synthesis of chiral succinates via Pd(0) catalyzed carbonylation/asymmetric hydrogenation sequence

We report a novel 4 step synthesis of chiral trisubstituted succinic acid derivatives utilizing carbonylation of a vinyl triflate followed by catalytic asymmetric hydrogenation to yield the title compounds.

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Brief introduction of Methyl 4-acetamido-5-chloro-2,3-dihydrobenzofuran-7-carboxylate

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ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES

Formula M (L A) x (L B) y and formula III, Is is a compound having structure of disclosure. Formula M (L A) x (L B) y in, ligands L A the And, ligands L B is the monovalent anionic bidentate ligands. In these compounds, metal M the atom number greater than 40 ; the x 1,2 or 3 and; 0,1 or 2 and the y; and oxidation state of a means of a metallic compound x+y M; L 11 alkyl, cycloalkyl, aryl and heteroaryl group connection selected from; L 12 the NR 15 and PR 15 exhibits connecting group selected from; R 1, R 2, R 3, R 4, R 5, R 6, R 11, R 12, R 13, R 14 and R 15 of independently permutes each and wherein the polymer is selected from group, wherein optionally the substituents of adjacent teeth any combination and and by forming rings fusion or non fusion; L A and L B at least the, optionally combined form ligands that digits you. Formula M (L A) x (L B) y formulations and including compound of their intensity such as OLED is disclosure. (by machine translation)

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Benzofuran – Wikipedia,
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Bicyclic [b]-heteroannulated pyridazine derivatives. 10. Acid cleavage of some beta-keto esters in the reaction with 4,4-dimethyl- and 4-phenyltetrahydropyridazine-3,6-dione 3-hydrazones

4,4-Dimethyltetrahydropyridazine-3,6-dione 3-hydrazone (1) reacted with beta-keto esters in refluxing ethanol to give the acid cleavage products: 7,8-dihydro-3,8,8-trimethyl-triazolo[4,3-b]pyridazin-6(5H)-one (7) and esters 9. The yield of the reaction in most cases was nearly quantitative. At room temperature mostly the simple condensation products 4 were isolated. In analogous reactions, 4-phenyltetrahydropyridazine-3,6-dione 3-hydrazone (2) was found to be much less reactive. The hydrazone-ester condensation products 4 and some 5 were converted into the corresponding pyrazolylpyridazine derivatives 10 and 11, respectively, by heating above their melting points; the formation of 7 was noted in the reactions with 4. The results support the concept of different tautomeric preferences in 1 and 2.

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A simple and efficient method for transesterification of beta-keto esters catalyzed by cesium fluoride

Cesium fluoride is found to be an efficient and reusable catalyst for the transesterification of beta-keto esters with various alcohols in good to high yields. Georg Thieme Verlag Stuttgart.

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Compositions for Treatment of Cystic Fibrosis and Other Chronic Diseases

The present invention relates to pharmaceutical compositions comprising an inhibitor of epithelial sodium channel activity in combination with at least one ABC Transporter modulator compound of Formula A, Formula B, Formula C, or Formula D. The invention also relates to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis using the pharmaceutical combination compositions.

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Benzofuran – Wikipedia,
Benzofuran | C8H4068O – PubChem

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RETROVIRAL PROTEASE INHIBITORS

N-heterocyclic moiety containing hydroxyethylamine compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.

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Synthesis of 2,2-functionalized benzo[1,3]dioxoles

Highly functionalized catechol ketals exhibiting either a tert-butyl moiety or a spiro center in position 2 are synthesized by ketalization and functionalized in a sequence of subsequent transformations. By a specific ketalization protocol catechol ketals of enolizable beta-keto esters can be prepared. With the succeeding steps these compounds incorporate moieties, which are not compatible and accessible by direct ketalization of catechol.

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Benzofuran – Wikipedia,
Benzofuran | C8H4075O – PubChem

Discovery of Methyl 4-acetamido-5-chloro-2,3-dihydrobenzofuran-7-carboxylate

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Recent Advances in Electrochemical Oxidative Cross-Coupling for the Construction of C-S Bonds

With the importance of sulfur-containing organic molecules, developing methodologies toward C-S bond formation is a long-standing goal, and, to date, considerable progress has been made in this area. Recent electrochemical oxidative cross-coupling reactions for C-S bond formation allow the synthesis of sulfur-containing molecules from more effective synthetic routes with high atom economy under mild conditions. In this review, we highlight the vital progress in this novel research arena with an emphasis on the synthetic and mechanistic aspects of the organic electrochemistry reactions. 1 Introduction 2 Electrochemical Oxidative Sulfonylation for the Formation of C-S Bonds 2.1 Applications of Sulfinic Acid Derivatives for the Formation of C-S Bonds 2.2 Applications of Sulfonylhydrazide Derivatives for the Formation of C-S Bonds 3 Electrochemical Oxidative Thiolation for the Formation of C-S Bonds 3.1 Applications of Disulfide Derivatives for the Formation of C-S Bonds 3.2 Applications of Thiophenol Derivatives for the Formation of C-S Bonds 4 Electrochemical Oxidative Thiocyanation for the Formation of C-S Bonds 5 Electrochemical Oxidative Cyclization for the Formation of C-S Bonds 6 Conclusion.

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Benzofuran – Wikipedia,
Benzofuran | C8H4095O – PubChem