Category: 10242-12-3

Application of 10242-12-3, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.10242-12-3, Name is 5-Nitrobenzofuran-2-carboxylic acid, molecular formula is C9H5NO5. In a Article£¬once mentioned of 10242-12-3

Microwave assisted Gould-Jacob reaction: Synthesis of 4-quinolones under solvent free conditions

A single step Gould-Jacob reaction between aromatic amines and diethyl ethoxymethylenemalonates (EMME) for the synthesis of 4-quinolones under solvent free microwave irradiation has been carried out and compared with classical heating.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 10242-12-3

Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H3521O – PubChem

10242-12-3, Name is 5-Nitrobenzofuran-2-carboxylic acid, belongs to benzofuran compound, is a common compound. Quality Control of 5-Nitrobenzofuran-2-carboxylic acidIn an article, once mentioned the new application about 10242-12-3.

A quinolone compound of green high-efficient synthetic method (by machine translation)

The invention discloses a quinolone compound of green high-efficient synthetic method. Method is as follows: step one, the second carbonyl compound, the original carboxylic acid triethyl and the aniline compound three-component raw materials in solvent-free and under the condition of catalyst reaction to obtain the enamine ester intermediate; step b, the enamine ester intermediate re-cyclization reagent ether under the effect of the molecule in the cyclization reaction to obtain the quinolone parent ring compound, the purity of the product up to 98.8% above. The synthesizing method of the invention the main advantages: 1. Step one efficient reaction, without the catalyst solvent use can avoid three waste generating high yield; 2. Step two process green, the cyclization reagent can be reclaimed and reused; 3. The process is simple, steps a and b can be carried out in the same reactor, the reaction end filter to get the quinolone compound. (by machine translation)

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Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H3517O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10242-12-3,5-Nitrobenzofuran-2-carboxylic acid,as a common compound, the synthetic route is as follows.

To a suspension of the bromo methyl seco compound prepared in step A in DMF was added EDC (10mg, 0.054mMoles) and 5-Nitro benzofuran carboxylic acid (12mg, 0.054 mMoles) and allowed to stir for 6 hours. To this reaction mixture was then added ethyl acetate and brine. The combined organic layers were concentrated after three extractions with ethyl acetate. And filterd over silica gel using MeOH/DCM with increasing amounts of MeOH The product was confirmed by Mass Spec, M+1 = 530, 10242-12-3

As the paragraph descriping shows that 10242-12-3 is playing an increasingly important role.

Reference£º
Patent; MEDAREX, INC.; WO2005/112919; (2005); A2;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

10242-12-3, 5-Nitrobenzofuran-2-carboxylic acid is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The achiral 2-(4-benzyloxy-2-nitrophenyl)ethyl chloride compound (0.500 g, 1.71 mmol) was dissolved in freezer-chilled THF (30 mL) and PtO2 (0.150 g) was added. The reaction was stirred while degassing under vacuum, followed by exposure to hydrogen gas. The degas/hydrogen exposure cycle was repeated 3 times, at which point the reaction was allowed to continue stirring under hydrogen at 50 psi at room temperature for one hour. The amine solution was filtered over Celite, and concentrated under reduced pressure. It was then coevaporated three times with dry CH2Cl2 (5 mL). A tan oil resulted and was placed under high vacuum, covered with foil for 30 minutes. Then, 5-nitrobenzofuran-2-carboxylic acid (0.394 g, 1.90 mmol) and PyBOP (0.999 g, 1.92 mmol) were suspended in dry CH2Cl2 (220 mL). The amine was then dissolved in dry CH2Cl2 (30 mL) and added to the suspension via a syringe through a septum. The reaction was allowed to stir for 10 minutes, at which point dry N,N-Diisopropylethylamine (0.75 mL, 4.29 mmol) was added to the suspension. The solution turned clear yellow. It was covered with foil and the solution was stirred under nitrogen, at room temperature for two days. The solution was vacuum filtered and the filtrate was washed with water (1¡Á75 mL), 10% HCl (1¡Á75 mL), saturated Sodium bicarbonate (1¡Á75 mL), and brine (1¡Á75 mL). The organic layer was dried over sodium sulfate, vacuum filtered, and concentrated under reduced pressure to yield a yellow solid. The residue was purified on a silica gel column using a 5-20% EtOAc/hexane solvent system to give the desired product 2-(4-benzyloxy-2-(5-nitrobenzofuran-2-carboxamido)phenyl)ethyl chloride as a yellow solid (0.173 g, 22% yield). Rf=0.22 (20% EtOAc/hexane) M.p. 109-113 C. IR (neat) 3370, 3088, 3032, 2945, 2858, 1690, 1531, 1337, 1270, 1168, 1101, 1025, 753, 610 1H-NMR (500 MHz, CDCl3) 8.67 (d, 2.0, 1H), 8.64 (s br, 1H), 8.39 (dd, 2.0, 9.0, 1H), 7.73 (s, 1H), 7.70 (d, 9.0, 1H), 7.65 (d, 2.5, 1H), 7.45 (d, 8.0, 2H), 7.40 (t, 8.0, 2H), 7.36 (t, 8.0, 1H), 7.19 (d, 8.5, 1H), 6.89 (dd, 2.5, 8.5, 1H), 5.10 (s, 2H), 3.83 (t, 6.5, 2H), 3.14 (t, 6.5, 2H). FAB-MS (NBA) 451 (M+H+, 11). Accurate mass for C24H19N2O5Cl+H: calcd. 451.1060; obs. 451.1050., 10242-12-3

The synthetic route of 10242-12-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Taiho Pharmaceutical Co. Ltd.; US6660742; (2003); B2;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

10242-12-3, 5-Nitrobenzofuran-2-carboxylic acid is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a suspension of 5-nitro-2-benzofurancarboxylic acid (5 g, 24.15 mmol) in CH2Cl2 (250 mL) at 0 C. was added DMF (0.100 mL) followed by (COCl)2 (2M in CH2Cl2, 36.23 mL, 72.46 mL) over a period of 10 min. The reaction was stirred at 0 C. for 1 h and then at room temperature for 30 min. The reaction solvent was removed under a reduced pressure, dried under high vacuum and again suspended in CH2Cl2 (250 mL). The solution was cooled to 0 C., were added pyridine (4.8 mL, 48.03 mmol) followed by McOH (10 mL, excess) and stirred overnight. The extractive work-up with CH2Cl2 gave the expected 2-methoxycarbonyl-5-nitrobenzofuran (R926609). 1H NMR (CDCl3): delta 8.66 (d, 1H, J=2.4 Hz), 8.36 (dd, 1H, J=2.4 and 9.6 Hz), 7.71 (d, 1H, J=9.3 Hz), 7.65 (s, 1H), 4.01 (s, 3H); LCMS: ret. time: 26.94 min.

10242-12-3, As the paragraph descriping shows that 10242-12-3 is playing an increasingly important role.

Reference£º
Patent; RIGEL PHARMACEUTICALS, INC.; Singh, Rajinder; Argade, Ankush; Payan, Donald; Molineaux, Susan; Holland, Sacha; Clough, Jeffrey; Keim, Holger; Bhamidipati, Somasekhar; Sylvain, Catherine; Li, Hui; Rossi, Alexander; US2015/266828; (2015); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

10242-12-3, 5-Nitrobenzofuran-2-carboxylic acid is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Compound 11 (0.414 g, 2 mmol), dichloromethane (5 mL), DMF (0.1 mL) was added to the reaction flask,(0.519 g, 6 mmol) oxalyl chloride. The reaction solution was allowed to stand at room temperature for 2 hours and concentrated. The residue was dissolved in acetone at 0 C, and then concentrated aqueous ammonia (7.5 mL) was added dropwise. The mixture was stirred for 10 minutes. A large amount of water was added to the reaction solution to precipitate a solid, And dried to give 0.28 g of compound 12 in a yield of 68%., 10242-12-3

Big data shows that 10242-12-3 is playing an increasingly important role.

Reference£º
Patent; Luoyang Juhui Pharmaceutical Technology Co., Ltd.; Zhang Hongli; Yang Songfeng; (36 pag.)CN106749203; (2017); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

10242-12-3, 5-Nitrobenzofuran-2-carboxylic acid is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Under nitrogen protection conditions, 5 mL of anhydrous dichloromethane was addedNitrobenzofuran-2-carboxylic acid (23 mg, 0.11 mmol)After stirring at room temperature, HOBt (18 mg, 0.13 mmol) was added,After stirring for 10 minutes, EDC ¡¤ HCl (25 mg,0.13 mmol) followed by the addition of compound III-8-a of Example 6(50 mg, 0.17 mmol) and DIPEA (0.04 mL, 0.22 mmol)TLC after 15 hours showed complete reaction,The reaction solution was washed with 5% NaHCO3 solution, 10% citric acid solution,5% NaHCO3 solution and saturated brine,Adding to the organic phase anhydrous sodium sulfate drying, drying and filtering,The solvent was removed using a rotary evaporator and the product was added directly to 5 mL of methanol,After stirring at room temperature, 2-methylpropylboronic acid (22 mg, 0.22 mmol) was added5 mL of n-hexane, followed by the addition of 1 M HCl solution (0.33 mL, 0.33 mmol)After 5 hours, the TLC assay showed complete reaction, the reaction solution was allowed to stand,The lower layer was washed with n-hexane, dried over anhydrous sodium sulfate,Drying after filtration, the use of rotary evaporator in addition to solvent,Column chromatography (dichloromethane: methanol = 60: 1) gave 17 mg of a yellow solid,Yield 48%, 10242-12-3

The synthetic route of 10242-12-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Fudan University; Shao Liming; Xu Yulong; Chen Yiyi; Li Wei; Xie Qiong; (36 pag.)CN107151255; (2017); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10242-12-3,5-Nitrobenzofuran-2-carboxylic acid,as a common compound, the synthetic route is as follows.

Compound 1 (300 mg) and HATU (551 mg) were dissolved in DMF (10 mL),DIEA (561 mg) was added dropwise thereto, and after stirring at room temperature for 15 minutes,Dimethylamine (2.2 mL, 2.0 M in THF) was then added to the reaction system.Stir for 20 hours at room temperature, dilute with saturated ammonium chloride solution, extract with ethyl acetate,The combined organic phases were dried over anhydrous sodium sulfate, the solvent was removed under reduced pressure,The obtained residue 2 (crude, 320 mg) was used directly in the next reaction.

10242-12-3, The synthetic route of 10242-12-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Shanghai Hongyi Biological Technology Co., Ltd.; Chinese Academy Of Sciences Shanghai Pharmaceutical Institute; Wu Rongguang; Li Jia; Yi Dewu; Zhou Yubo; Ye Wei; Wang Peipei; Xiang Junfeng; Zhang Kaixiang; Hu Xiaobei; (61 pag.)CN110872296; (2020); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

10242-12-3, 5-Nitrobenzofuran-2-carboxylic acid is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Ethyl 5-nitro-1-benzofuran-2-carboxylate (2.0 g, 8.54 mmol) was suspended in a mixed solvent of methanol (3.2 mL) and THF (3.2 mL), then a 4 mol/L aqueous solution of sodium hydroxide (3.2 mL) was added thereto, and the mixture was stirred at 70C for 1 hour. A 1 mol/L aqueous solution of hydrochloric acid was added to the reaction solution, followed by extraction with ethyl acetate twice. The organic layer was washed with a saturated saline solution, dried over anhydrous sodium sulfate and filtered, and then the solvent was concentrated under reduced pressure to obtain a crude product. The obtained crude product was dissolved in DMF (20 mL), then 1,1-di-tert-butoxy-N,N-dimethylmethaneamide (13.9 g, 68.32 mmol) was added, and the mixture was stirred at 80C for 11 hours. Water was added to the reaction solution, followed by extraction with ethyl acetate. The organic layer was washed with a saturated saline solution, dried over anhydrous sodium sulfate and filtered, and then the organic layer was concentrated under reduced pressure to obtain a crude product. Chloroform (10 mL) was added to the obtained crude product, and the crystal was filtered out to obtain the title compound (1.76 g, 78%). 1H NMR (CDCl3, 300 MHz) delta 12.43 (s, 1H), 8.13-8.11 (m, 1H), 7.61-7.59 (m, 1H), 7.34 (s, 1H), 2.11-1.98 (m, 4H), 1.64-1.59 (m, 9H).

10242-12-3, The synthetic route of 10242-12-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Sumitomo Dainippon Pharma Co., Ltd.; IKUMA Yohei; FUKUDA Nobuhisa; IWATA Masato; KIMURA Hidenori; SUZUKI Kuniko; EP2876105; (2015); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem