With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.496-41-3,Benzofuran-2-carboxylic acid,as a common compound, the synthetic route is as follows.,496-41-3
In a 50 mL round bottom flask equipped with a magnetic stirrer,Benzofuran-2-carboxylic acid (162 mg, 1.0 mmol, 1.0 eq),Selectfluor (708 mg, 2.0 mmol, 2.0 eq), potassium fluoride(232 mg, 4.0 mmol, 4.0 eq); then dichloroethane (3.3 mL) and water (1.7 mL) were added as solvent;The reaction bottle was sealed in an oil bath at 70 C and heated and stirred for 15 hours. After the reaction was completed,The reaction mixture was extracted twice with 20 mL of ether. The organic phase was combined and washed with saturated brine and then dried over anhydrous sodium sulfate. After drying,Solvent to give the crude product; the crude product was subjected to column separation using analytically pure n-pentane as eluent to give the final productThe 2-fluorobenzofuran was a yellow oily liquid in 75% yield.
As the paragraph descriping shows that 496-41-3 is playing an increasingly important role.
Reference£º
Patent; Central South University; Tang, Zhenyu; Yuan, Xi; Yao, Jianfei; (24 pag.)CN106397377; (2017); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem