Reference of 496-41-3, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, and a compound is mentioned, 496-41-3, Benzofuran-2-carboxylic acid, introducing its new discovery.
The Generation and Synthetic Utility of Dianions derived from Benzofurancarboxylic Acids
The dianionic species, lithium 2-lithiobenzofuran-3-carboxylate (5) and lithium 3-lithiobenzofuran-2-carboxylate (11b) can be readily generated from the parent acids by reaction with lithium diisopropylamide in tetrahydrofuran at low temperatures.While compound (5) is a useful synthetic intermediate, which reacts efficiently with a number of electrophiles, (11b) instead undergoes rapid opening of the furan ring to give (2-hydroxyphenyl)propynoic acid (10a).By contrast, 5- and 7-methoxybenzofuran-2-carboxylic acids (13a) and (13c) give rise to the dianions (14a) and (14c) which are sufficiently stable at <= -90 deg C to be trapped by aldehydes.The dianion (14b) derived from 6-methoxybenzofuran-2-carboxylic acid (13b), however, suffers rapid ring opening before it can be trapped, even at very low temperatures.A plausible explanation of these observations is given.Metallation of 3-methylbenzofuran-2-carboxylic acid (18) affords the dianion (20), which cannot undergo ring opening and which is a valuable intermediate for the synthesis of a range of 3-substituted benzofuran-2-carboxylic acids. Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Reference of 496-41-3. In my other articles, you can also check out more blogs about 496-41-3
Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H1752O – PubChem