One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Recommanded Product: 5-Methoxybenzofuran-3(2H)-one, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 39581-55-0, Name is 5-Methoxybenzofuran-3(2H)-one, molecular formula is C9H8O3
Death-associated protein kinase-related apoptosis-inducing kinase-2 (DRAK2) is a serine/threonine kinase that plays a key role in a wide variety of cell death signaling pathways. Inhibition of DRAK2 was found to efficiently protect islet beta-cells from apoptosis and hence DRAK2 inhibitors represent a promising therapeutic strategy for the treatment of diabetes. Only very few chemical entities targeting DRAK2 are currently known. We carried out a high throughput screening and identified compound 4 as a moderate DRAK2 inhibitor with an IC50value of 3.15 muM. Subsequent SAR studies of hit compound 4 led to the development of novel benzofuran-3(2H)-one series of DRAK2 inhibitors with improved potency and favorable selectivity profiles against 26 selected kinases. Importantly, most potent compounds 40 (IC50 = 0.33 muM) and 41 (IC50 = 0.25 muM) were found to protect islet beta-cells from apoptosis in dose-dependent manners. These data support the notion that small molecule inhibitors of DRAK2 represents a promising strategy for the treatment of diabetes.
One of the oldest and most widely used commercial enzyme inhibitors is aspirin, Recommanded Product: 5-Methoxybenzofuran-3(2H)-one, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 39581-55-0
Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H2248O – PubChem