Month: February 2023

Fluoran derivatives. IV. Electronic absorption and emission spectra of mono- and disubstituted derivatives of 3,3-diphenylphthalide and fluoran was written by Gronowska, Janina;Rakowska, Tersa;Walerys, Henryk. And the article was included in Roczniki Chemii in 1973.Name: 3′,6′-Dimethoxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one This article mentions the following:

The effect of Me, OMe, and OH groups on the electronic absorption spectra in 96% EtOH and absorption and emission spectra in 80% H2SO4 was determined for I (R = H, Me; R1 = H, Me, OMe, OH) and II (R,R1 = H, Me, OMe, OH). I were prepared by condensation of the corresponding aroylbenzoic acids with a substituted phenol in the presence of anhydrous ZnCl2 at 95-105°; demethylation and formation of phenolic products was observed at higher temperatures In the experiment, the researchers used many compounds, for example, 3′,6′-Dimethoxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 36886-76-7Name: 3′,6′-Dimethoxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one).

3′,6′-Dimethoxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 36886-76-7) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Name: 3′,6′-Dimethoxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Synthesis of CoSnS₂ hollow nanocubes with NIR-enhanced chemodynamic therapy and glutathione depletion for combined cancer therapy was written by Zhu, Xuerui;Chu, Zhaoyou;Chen, Benjin;Jin, Qianqian;Ma, Xuke;Yang, Juan;Jiang, Yongxin;Wang, Wanni;Zha, Zhengbao;Qian, Haisheng. And the article was included in Materials Chemistry Frontiers in 2022.HPLC of Formula: 1461-15-0 This article mentions the following:

Low concentrations of endogenous hydrogen peroxide (H₂O₂) and intrinsic oxidative stress defense system greatly limited the efficiency of Fenton and Fenton-like reactions driven by a single metal element. Moreover, the complex physiol. environment and inherent self-healing function of tumors make it difficult for chemodynamic therapy (CDT) alone, driven by Fenton and Fenton-like reactions, to eliminate malignant tumors. Herein, a tumor microenvironment (TME) remodeling cobalt-stannous sulfide CoSnS2 (CSS) hollow nanocubes are presented for photothermal therapy (PTT)-improved CDT, in which two redox pairs (Co²⁺/Co³⁺ and Sn²⁺/Sn⁴⁺) are involved in catalyzing H₂O₂ to generate a large number of toxic hydroxyl radicals ( OH) resulting in massive apoptosis of tumor cells. Importantly, two redox pairs (Co²⁺/Co³⁺ and Sn²⁺/Sn⁴⁺) promoted the depletion of glutathione (GSH), which reduced tumor antioxidant capacity and thus enhanced the CDT therapeutic impact of CDT. Furthermore, the CDT efficiency was greatly improved by the excellent photothermal effect (η = 47.23%). The combination of PTT and CDT achieved good therapeutic effects, which may provide a new perspective for the development of other anti-tumor strategies on the basis of improved CDT and modulation of TME. In the experiment, the researchers used many compounds, for example, 2,2′,2”,2”’-(((3′,6′-Dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-2′,7′-diyl)bis(methylene))bis(azanetriyl))tetraacetic acid (cas: 1461-15-0HPLC of Formula: 1461-15-0).

2,2′,2”,2”’-(((3′,6′-Dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-2′,7′-diyl)bis(methylene))bis(azanetriyl))tetraacetic acid (cas: 1461-15-0) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.HPLC of Formula: 1461-15-0

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Prucalopride for the treatment of ileus was written by Smart, Christopher J.;Malik, Kamran I.. And the article was included in Expert Opinion on Investigational Drugs in 2017.Related Products of 179474-81-8 This article mentions the following:

Postoperative ileus (POI) is an impairment of coordinated gastrointestinal (GI) motility that develops as a consequence of abdominal surgery and is a major factor contributing to patient morbidity and prolonged hospitalisation. Despite the availability of various options its treatment is still under debate. This review will focus on effect of Prucalopride (5-HT₄ receptor agonist) on postoperative ileus based on the existing literature. A literature search of MEDLINE, EMBASE and COCHRANE Library was performed concerning topics related to the treatment of ileus with prucalopride. The search strategy also included articles relating to other treatments of ileus for comparison with prucalopride. Postoperative ileus remains difficult to treat and most strategies encompass preventative measures through enhanced recovery after surgery and laparoscopic approaches. The role of pharmacol. intervention is developing with some drugs licensed for use. The evidence for prucalopride remains unclear although there is randomised controlled trial (RCT) evidence available. Given the potential for reduction in patient morbidity and length of stay the role of prucalopride in POI should be further investigated with multi-center RCTs to establish which group of patients will gain the most from this exciting potential treatment. In the experiment, the researchers used many compounds, for example, 4-Amino-5-chloro-N-(1-(3-methoxypropyl)piperidin-4-yl)-2,3-dihydrobenzofuran-7-carboxamide (cas: 179474-81-8Related Products of 179474-81-8).

4-Amino-5-chloro-N-(1-(3-methoxypropyl)piperidin-4-yl)-2,3-dihydrobenzofuran-7-carboxamide (cas: 179474-81-8) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.Related Products of 179474-81-8

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Process for preparing a benzofurancarboxamide compound was written by Anonymous. And the article was included in IP.com Journal in 2016.SDS of cas: 179474-81-8 This article mentions the following:

Process for preparing 4-amino-5-chloro-2,3-dihydro-N-[1-(3-methoxypropyl)-4-piperidinyl]-7-benzofurancarboxamide butanedioate (1:1) was disclosed. In the experiment, the researchers used many compounds, for example, 4-Amino-5-chloro-N-(1-(3-methoxypropyl)piperidin-4-yl)-2,3-dihydrobenzofuran-7-carboxamide (cas: 179474-81-8SDS of cas: 179474-81-8).

4-Amino-5-chloro-N-(1-(3-methoxypropyl)piperidin-4-yl)-2,3-dihydrobenzofuran-7-carboxamide (cas: 179474-81-8) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.SDS of cas: 179474-81-8

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Identification of chemical constituents in vitro and in vivo of Er Shen Zhenwu Decoction by utilizing ultra-high-performance liquid chromatography with quadrupole time-of-flight mass spectrometry was written by Hong, Li-Li;Zhao, Yan;Yang, Chen-Yu;Li, Guo-Zhuang;Wang, Hong-Song;Chen, Wei-Dong;Cheng, Xiao-Yu;Liu, Li. And the article was included in Journal of Separation Science in 2021.Recommanded Product: (R)-3-(3,4-Dihydroxyphenyl)-1-methoxy-1-oxopropan-2-yl (2S,3S)-2-(3,4-dihydroxyphenyl)-4-((E)-3-(((R)-3-(3,4-dihydroxyphenyl)-1-methoxy-1-oxopropan-2-yl)oxy)-3-oxoprop-1-en-1-yl)-7-hydroxy-2,3-dihydrobenzofuran-3-carboxylate This article mentions the following:

Er Shen Zhenwu Decoction is a prescription for treating chronic heart failure of heart and kidney yang deficiency, while its active ingredients remain unclear and difficult to identify. This paper aims to apply a rapid assay strategy of ultra-high-performance liquid chromatog.-quadrupole time-of-flight mass spectrometry to collect the mass spectrometry data of Er Shen Zhenwu Decoction and its decomposed recipes (monarch, minister, and assist). By comparing with retention time and MSE fragmentation patterns, 67 and 34 components in vitro and in vivo were identified, resp., the main ingredients include saponins, terpenes, alkaloids, phenolic acids, tanshinone, urea, steroids, aromatics, organic acids, carbohydrates, and so forth, of which the monarch medicine > minister medicine > assist medicine. By comparison with reference standards, paeoniflorin, rosmarinic acid, ginsenoside Rg1, ginsenoside Re, ginsenoside Rb1 and atractylenolide III were identified in vitro and paeoniflorin, ginsenoside Rg1, ginsenoside Re and ginsenoside Rb1 were identified in vivo. In this study, the chem. ingredients of Er Shen Zhenwu Decoction were analyzed by ultra-high-performance liquid chromatog.-quadrupole time-of-flight mass spectrometry technol. and each compound was grouped into the decomposed recipes. The identified substances can be used as references for Er Shen Zhenwu Decoction quality control and potential medicinal substances in chronic heart failure of heart and kidney yang deficiency treatment. In the experiment, the researchers used many compounds, for example, (R)-3-(3,4-Dihydroxyphenyl)-1-methoxy-1-oxopropan-2-yl (2S,3S)-2-(3,4-dihydroxyphenyl)-4-((E)-3-(((R)-3-(3,4-dihydroxyphenyl)-1-methoxy-1-oxopropan-2-yl)oxy)-3-oxoprop-1-en-1-yl)-7-hydroxy-2,3-dihydrobenzofuran-3-carboxylate (cas: 875313-64-7Recommanded Product: (R)-3-(3,4-Dihydroxyphenyl)-1-methoxy-1-oxopropan-2-yl (2S,3S)-2-(3,4-dihydroxyphenyl)-4-((E)-3-(((R)-3-(3,4-dihydroxyphenyl)-1-methoxy-1-oxopropan-2-yl)oxy)-3-oxoprop-1-en-1-yl)-7-hydroxy-2,3-dihydrobenzofuran-3-carboxylate).

(R)-3-(3,4-Dihydroxyphenyl)-1-methoxy-1-oxopropan-2-yl (2S,3S)-2-(3,4-dihydroxyphenyl)-4-((E)-3-(((R)-3-(3,4-dihydroxyphenyl)-1-methoxy-1-oxopropan-2-yl)oxy)-3-oxoprop-1-en-1-yl)-7-hydroxy-2,3-dihydrobenzofuran-3-carboxylate (cas: 875313-64-7) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Recommanded Product: (R)-3-(3,4-Dihydroxyphenyl)-1-methoxy-1-oxopropan-2-yl (2S,3S)-2-(3,4-dihydroxyphenyl)-4-((E)-3-(((R)-3-(3,4-dihydroxyphenyl)-1-methoxy-1-oxopropan-2-yl)oxy)-3-oxoprop-1-en-1-yl)-7-hydroxy-2,3-dihydrobenzofuran-3-carboxylate

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Chemical constituents of picrasma quassioides (d. don) benn. was written by Zhu, Chen-chen;Deng, Gui-hua;Lin, Chao-zhan. And the article was included in Tianran Chanwu Yanjiu Yu Kaifa in 2012.Quality Control of (2S,3R,4S,5S,6R)-2-(((6aR,12aR)-6a,12a-Dihydro-6H-[1,3]dioxolo[4′,5′:5,6]benzofuro[3,2-c]chromen-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol This article mentions the following:

Five compounds were isolated and purified from the 95% ethanol extract of Picrasma quassioides(D. Don) Benn. by using column chromatog. and recrystallization Based on the spectroscopic methods, their structures were identified as trifolirhizin(1), maackiain(2), 3′,7-dihydroxy-4′-methoxyisoflavone(3), umbelliferone(4), and emodin(5). All the Compounds are reported from the genus Picrasma for the first time. In the experiment, the researchers used many compounds, for example, (2S,3R,4S,5S,6R)-2-(((6aR,12aR)-6a,12a-Dihydro-6H-[1,3]dioxolo[4′,5′:5,6]benzofuro[3,2-c]chromen-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 6807-83-6Quality Control of (2S,3R,4S,5S,6R)-2-(((6aR,12aR)-6a,12a-Dihydro-6H-[1,3]dioxolo[4′,5′:5,6]benzofuro[3,2-c]chromen-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol).

(2S,3R,4S,5S,6R)-2-(((6aR,12aR)-6a,12a-Dihydro-6H-[1,3]dioxolo[4′,5′:5,6]benzofuro[3,2-c]chromen-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 6807-83-6) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Quality Control of (2S,3R,4S,5S,6R)-2-(((6aR,12aR)-6a,12a-Dihydro-6H-[1,3]dioxolo[4′,5′:5,6]benzofuro[3,2-c]chromen-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Study on serum active constituents of rats intragastrically given decoction of fructus psoraleae was written by Song, Dian-rong;Song, Hong-yun;Wang, Yue-fei;Guo, Jie;Xu, Yan-ying;Pan, Gui-xiang. And the article was included in Zhonghua Zhongyiyao Zazhi in 2010.Safety of (Z)-3-(6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)benzofuran-5-yl)acrylic acid This article mentions the following:

Objective: To investigate the active constituents in decoction of Fructus Psoraleae by serum pharmacochem., and illuminate the elemental pharmacodynamic constituents, and provide the foundation for optimizing the prescription of fructus psoraleae. Methods: Based on the establishment of HPLC fingerprint of decoction of Fructus Psoraleae, rat serum were obtained after being given with decoction of Fructus Psoraleae 1 h and 12 h, compared HPLC fingerprints of blank serum, serum containing drug and decoction of Fructus Psoraleae, and the serum active constituents in decoction of Fructus Psoraleae were analyzed. Results: Psoralenoside, isopsoralenoside, psoralen and isopsoralen and the unknown constituent Number3 chromatog. peak were determined in the decoction of Fructus Psoraleae. Psoralenoside, isopsoralenoside, psoralen and isopsoralen were determined in the rat serum after being intragastrically administrated decoction of Fructus Psoraleae 1 h and 12 h. Conclusion: Psoralenoside, isopsoralenoside, psoralen and isopsoralen were the main active constituents and the elemental pharmacodynamic constituents of the decoction of Fructus Psoraleae. In the experiment, the researchers used many compounds, for example, (Z)-3-(6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)benzofuran-5-yl)acrylic acid (cas: 905954-17-8Safety of (Z)-3-(6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)benzofuran-5-yl)acrylic acid).

(Z)-3-(6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)benzofuran-5-yl)acrylic acid (cas: 905954-17-8) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Safety of (Z)-3-(6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)benzofuran-5-yl)acrylic acid

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Halodeboronation of organotrifluoroborates using tetrabutylammonium tribromide or cesium triiodide was written by Yao, Min-Liang;Kabalka, George W.;Blevins, David W.;Reddy, Marepally Srinivasa;Yong, Li. And the article was included in Tetrahedron in 2012.Application of 929626-27-7 This article mentions the following:

Halodeboronation of organotrifluoroborates using com. available tetrabutylammonium tribromide (TBATB) or cesium triiodide in aqueous medium is reported. The mild, transition metal-free method has proven to be tolerant of a wide range of functional groups. High regio- and chemoselectivity are observed Two synthetic routes to (Z)-dibromoalkenes from alkynes, through stereodefined (Z)-2-bromoalkenyltrifluoroborates and (Z)-1,2-bis(boryl)alkenyltrifluoroborates, have been developed using the TBATB mediated bromodeboronation as the key step. In the experiment, the researchers used many compounds, for example, Potassium benzofuran-2-yltrifluoroborate (cas: 929626-27-7Application of 929626-27-7).

Potassium benzofuran-2-yltrifluoroborate (cas: 929626-27-7) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Application of 929626-27-7

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Generation of local redox potential from confined nano-bimetals in porous metal silicate materials for high-performance catalysis was written by Liu, Yang-Yang;Shi, Xiao-Ke;Wu, Chuan-De. And the article was included in Catalysis Science & Technology in 2022.COA of Formula: C8H8O This article mentions the following:

Partial hydrogenation of polycyclic aromatic hydrocarbons (PAHs) could not only produce highly value-added chems. but also reduce environmental pollution; however, the partial hydrogenation reaction has to be performed under extreme conditions in the presence of precious metal-based catalysts, because PAHs are a class of inactive reactants. We report herein a porous metal silicate (PMS) material, PMS-16, that consists of Co and Ni bimetal redox-active species and BIII Lewis acid sites, demonstrating high catalytic activity (>99% conversion) and selectivity (>99%) for hydrogenation of a series of PAHs under mild conditions, which is much superior to noble metal-based catalysts in the literature. The unique catalytic properties of PMS-16 are derived from the synergistic work between Ni and Co metal species by sep. activating different reactant mols. and generating local redox potential to prompt electron and charge transfer. The catalyst is simply produced and very stable for industrial applications. In the experiment, the researchers used many compounds, for example, 2,3-Dihydrobenzo[b]furan (cas: 496-16-2COA of Formula: C8H8O).

2,3-Dihydrobenzo[b]furan (cas: 496-16-2) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.COA of Formula: C8H8O

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Valuable chemicals identified from Flourensia species using vacuum and analytical pyrolysis was written by Silva, Mariana P.;Nieva Lobos, Maria L.;Larson, Tony R.;McQueen-Mason, Simon;Gomez, Leonardo D.;Moyano, E. Laura;Scopel, Ana L.. And the article was included in Journal of Analytical and Applied Pyrolysis in 2022.Related Products of 496-16-2 This article mentions the following:

The genus Flourensia, present throughout most of the Americas has been identified as a source of renewable chems. Here, we characterized the aerial biomass and matrix polysaccharides of Flourensia campestris, F. oolepis and F. riparia, and explored their potential as a source of chems. through the study of two techniques: anal. pyrolysis (PY-GC/MS) and vacuum pyrolysis (VP). In all species, hemicellulose was more abundant than cellulose and lignin, with galacturonic acid being the most abundant monosaccharide. Bio-oils from VP exhibited a complex combination of phenols, terpenes, furans and nitrogen-containing compounds which have a wide range of industrial applications. Differences between the composition of VP pyrolytic oils derived from the mixture of leaves and stems or from individual organs suggest possible interactions between biopolymers. Combining PY-GC/MS and principal component anal. (PCA) we identified fingerprints for leaves and stems of the three Flourensia species. In the experiment, the researchers used many compounds, for example, 2,3-Dihydrobenzo[b]furan (cas: 496-16-2Related Products of 496-16-2).

2,3-Dihydrobenzo[b]furan (cas: 496-16-2) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.Related Products of 496-16-2

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem