Day: December 6, 2022

Thiel, A. published the artcileBicolored phthaleins, Application of 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one, the publication is Z. physik. Chem. (1931), 352-6, database is CAplus.

The phthaleins of the series homologous to phenolphthalein have been assumed to show but one color change. α-Naphtholphthalein on very careful purification lost its pink to brownish color and was obtained colorless. In alc. the color changes are from colorless to orange-yellow and then by way of green to blue. This is difficult to observe in water because of the limited solubility of the free phthalein. p-Xylenolphthalein and thymolphthalein show similar color changes including the colorless stage in alc. The 1st change is from the colorless phthalein to that of the primary quinoid anions, and the 2nd change is from this color to the deep color of the secondary meriquinoid anions.

Z. physik. Chem. published new progress about 596-01-0. 596-01-0 belongs to benzofurans, auxiliary class Benzofuran,Naphthalene,Alcohol,Ester, name is 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one, and the molecular formula is C11H21BF4N2O2, Application of 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Rozman, Martin published the artcileMulticolor Transparent-Conductive-Electrode Free Electronic Paper based on Steel Foil and Water Electrolyte with pH Indicator Dyes, Product Details of C28H18O4, the publication is Advanced Electronic Materials (2022), 8(4), 2100901, database is CAplus.

Electronic paper devices, also known as electrochromic devices, are known for their ability to change color and remain in a particular color state even after the elec. power is turned off. Traditional devices such as electrochromic windows use mechanisms such as electrophoresis or intercalation and use special materials such as anhydrous electrolytes and transparent conductive materials (TCMs). As a result, these devices can sometimes be relatively difficult to assemble, especially in developing countries where such materials are difficult to obtain. Recently, some improvements are made by using alternative electrode positioning that do not require TCM. Here, a novel multicolor display module that is recyclable, can be fabricated from readily available materials, and can be scaled according to the desired screen size is presented. The presented device is a semi-open electrochem. device that uses pH indicator dyes and an aqueous electrolyte solution in combination with readily available stainless steel sheet.

Advanced Electronic Materials published new progress about 596-01-0. 596-01-0 belongs to benzofurans, auxiliary class Benzofuran,Naphthalene,Alcohol,Ester, name is 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one, and the molecular formula is C28H18O4, Product Details of C28H18O4.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Rohatgi, H. L. published the artcileOrganomercury derivatives as antiseptics. II. Symmetrical phthaleins and fluoresceins, Recommanded Product: 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one, the publication is Indian Journal of Applied Chemistry (1958), 117-20, database is CAplus.

Several sym. phthaleins and fluoresceins, their Hg and Br derivatives, were prepared and tested for bactericidal activity. Phthalic anhydride was treated with phenols to give the following compounds (phenol, % yield, dye formula, m.p. given): m-cresol, 54, C₂₂H₁₆O₃, 215°; p-cresol, 54, C₂₂H₁₆O₃, 246°; pyrocatechol, 54, C₂₀H₁₂O₅, 200°; hydroquinone, 51, C₂₀H₁₂O₅, 226°; pyrogallol, 71, C₂₀H₁₂O₇, 285°; phloroglucinol, 57, C₂₀H₁₂O₇, 250°; 1-naphthol, 49, C₂₈H₁₈O₄, 234-5°; and 2-naphthol, 50, C₂₈H₁₆O₃, 293°. The dyes were mercurated by the method of White (C.A. 15, 536) and the Hg substituents replaced by Br to give the following derivatives (dye, formula of Hg derivative, color of Hg derivative, color of Br derivative, m.p. of Br derivative given): phenolphthalein, C₂₀H₁₁O₄(HgOAc)₂(HgOH)₂, light pink, light red, >300°; ο-cresolphthalein, C₂₂H₁₆O₄(HgOAc)₂, green, orange, 255°; 3,6-dimethylfluoran, C₂₂H₁₄O₃(HgOAc)₂, brown, orange, 249-50°; 2,7-dimethylfluoran, C₂₂H₁₄O₃(HgOAc)₂, brown, orange, 984-5°; 4,5-dihydroxyfluoran, C₂₀H₁₀O₅(HgOH)₂, green, dirty orange, 285°; 3,6-dihydroxyfluoran, C₂₀H₈O₅(HgOAc)₄ red, orange-red, >300°; 2,7-dihydroxyfluoran, C₂₀H₁₀O₅(HgOH)₂, brown, dirty orange, 200° (decomposition); 4,5-dihydroxyfluorescein, C₂₀H₁₀O₇(HgOAc)₂, deep red, red, >300°; 1,8-dihydroxyfluorescein, C₂₀H₈O₇(HgOAc)₄, dirty red, red, >300°; α-naphthophthalein, C₂₈H₁₇O₄HgOAc, black, brown, >300°; and β-naphthophthalein, C₂₈H₁₅O₃HgOAc, black-brown, >300°. The mercurated compounds were more active against Staphylococcus aureus and Escherichia coli than the dyes but not more active than mercurochrome.

Indian Journal of Applied Chemistry published new progress about 596-01-0. 596-01-0 belongs to benzofurans, auxiliary class Benzofuran,Naphthalene,Alcohol,Ester, name is 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one, and the molecular formula is C28H18O4, Recommanded Product: 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Robien, Wolfgang published the artcileThe advantage of automatic peer-reviewing of 13C-NMR reference data using the CSEARCH-protocol, Name: 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, the publication is Molecules (2021), 26(11), 3413, database is CAplus and MEDLINE.

A systematic investigation of the exptl. 13C-NMR spectra published in Mols. during the period of 1996 to 2015 with respect to their quality using CSEARCH-technol. is described. It is shown that the systematic application of the CSEARCH-Robot-Referee during the peer-reviewing process prohibits at least the most trivial assignment errors and wrong structure proposals. In many cases, the correction of the assignments/chem. shift values is possible by manual inspection of the published tables; in certain cases, reprocessing of the original exptl. data might help to clarify the situation, showing the urgent need for a public domain repository. A comparison of the significant key numbers derived for Mols. against those of other important journals in the field of natural product chem. shows a quite similar level of quality for all publishers responsible for the six journals under investigation. From the results of this study, general rules for data handling, data storage, and manuscript preparation can be derived, helping to increase the quality of published NMR-data and making these data available as validated reference material.

Molecules published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C14H10O4, Name: 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Novikova, E. N. published the artcileEffect of substituents in molecules of inhibitors on their protective action in autoxidation of α-pinene, Name: 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one, the publication is Zhurnal Obshchei Khimii (1958), 1993-7, database is CAplus.

The effect of various inhibitors on autoxidation and formation of peroxides in α-pinene was studied in scattered light at 18-20°. The inhibitors were added in 0.01 millimolar amount to 1 mole of pinene, and the reaction was permitted to occur in contact with air at room temperature for up to 150 days. Peroxide formation is hindered by pyrocatechol, pyrogallol, o- and p-aminophenols, p-hydroxydiphenylamine, dinaphthylphenylenediamine, 1,4-diphenylphenylenediamine, p-aminodiphenylamine, 1-naphthol, and p-hydroxypheyl-2-naphthylamine. Derivatives of phenols were weak inhibitors. Fe palmitate is an initiator for peroxidation of pinene. The activity of the inhibitor is determined both by the polarity of the substance and the mobility of available H atoms.

Zhurnal Obshchei Khimii published new progress about 596-01-0. 596-01-0 belongs to benzofurans, auxiliary class Benzofuran,Naphthalene,Alcohol,Ester, name is 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one, and the molecular formula is C28H18O4, Name: 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Novikova, E. N. published the artcileEffect of the inhibitors on the formation of peroxides in α-pinene, Recommanded Product: 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one, the publication is Vestsi Akademii Navuk BSSR, Seryya Fizika-Tekhnichnykh Navuk (1957), 47-55, database is CAplus.

To a 25 mL. glass tube was added 4 mL. freshly distilled α-pinene (I), d₂₀ 0.8573, n²⁰_D 1.4665, b. 155-6°, containing 4 m mol inhibitor/100 mL. I, and the tube placed in an oil bath at 110° for air oxidation during 2 h. The amount of peroxides (II) formed was then determined iodometrically and calculated as ml. 0.1N hyposulfite solution/l. oxidized I. Secondary aromatic amines: dinaphthylphenylenediamine, p-H₂NC₆H₄NHPh, 2,4 – (H₂N)₂C₆H₃NHPh, 1,4 – diphenylenediamine, and p-HOC₆H₄NHPh caused total inhibition of the formation of II. Other equally effective inhibitors were p-hydroxyphenyl-β-naphthylamine, ο-, and p-aminophenol. The following aromatic compounds showed a much smaller inhibitory effect (in the decreasing order of the inhibitory efficiency): α-naphthol, phenyl-α-naphthylamine, nitrosodimethylamine, dihydroxynaphthalene, α-naphtholphthalein, hydroxyquinoline, phenyl-β-naphthylamine (III), and “aldol-α-naphthylamine” (titration values 1.5-10.1 mL. vs. 51.2-57.8 mL. for the controls), and hydroquinone (IV), pyrocatechol, pyrogallol, β-naphthol, β-naphthylamine, dianisidine, α-naphthylamine, phloroglucinol, resorcinol, Azatol A, p-toluidine, p-anisidine, nitroresorcinol, orcinol, m-tolylenediamine, ο-anthranilic acid, m-anthranilic acid, m-aminophenol, naphthalene, benzidine, ο-tolidine, hydroxyquinoline, and biphenyl (titration values from 11.8 to 50.4 mL.). Primary amines showed the lower inhibition. Naphthols were more effective than naphthylamines. ο- and p-Isomers of phenols and aminophenols inhibited formation of II more than did m-isomers. In another experiment, conducted on I and dipentene (fraction of turpentine, d₂₀ 0.8486, n²⁰_D 1.474, b. 174-5°), by using a dry O oxidation in a semivacuum at 80° 4 h., it was shown that the inhibitors are equally effective against formation of I in dry O as in the air. Addition of 0.005% Mn (as Mn stearate) to I did not increase the inhibitory effects of III and IV as found by the determinations of II and the O absorption by I. Triphenylphosphine and IV were found to be strong inhibitors against oxidation of terpenes. The inhibitory effects of the aromatic compounds against formation of II in I is discussed in the light of the chem. and structural nature of the inhibitors.

Vestsi Akademii Navuk BSSR, Seryya Fizika-Tekhnichnykh Navuk published new progress about 596-01-0. 596-01-0 belongs to benzofurans, auxiliary class Benzofuran,Naphthalene,Alcohol,Ester, name is 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one, and the molecular formula is C28H18O4, Recommanded Product: 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Murata, Kazuya published the artcileChemical Diversity of β-Secretase Inhibitors From Natural Resources, Recommanded Product: 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, the publication is Natural Product Communications (2019), 14(12), 1934578X19894819, database is CAplus.

A review. Reports on β-secretase inhibitors of natural origin are listed in order to reveal their chem. diversity. Various types of compounds were found to inhibit β-secretase, and natural resources included a wide spectrum of biol. species. Among them, some triterpenes and moracin derivatives, which are nonpeptidic compounds, were determined to be competitive inhibitors. In addition, no peptide compounds were reported from natural resources. These points will be clarified in future studies.

Natural Product Communications published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C14H10O4, Recommanded Product: 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Moir, James published the artcileColor and chemical constitution. XX. Some residual problems, Related Products of benzofurans, the publication is Transactions of the Royal Society of South Africa (1926), 131-8, database is CAplus.

cf. C. A. 19, 988. Locations of absorption bands are given for a considerable number of naphtholphthaleins, azo dyes, hydrazones, S compounds, and miscellaneous organic compounds Com. α-naphtholphthalein was shown to consist chiefly of a white substance (I) together with a small quantity of a brown substance (II). Apparently I is mostly the p,p’-isomer, with a little o,p (as with com. phenolphthalein); II is the o,o’-isomer, m. 234°.

Transactions of the Royal Society of South Africa published new progress about 596-01-0. 596-01-0 belongs to benzofurans, auxiliary class Benzofuran,Naphthalene,Alcohol,Ester, name is 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one, and the molecular formula is C28H18O4, Related Products of benzofurans.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Marquez, Luis Alberto Ponce published the artcileSynthesis and chemical study of some phenolic phthaleins and their halogenated derivatives, Product Details of C28H18O4, the publication is Anales de la Facultad de Farmacia y Bioquimica, Universidad Nacional Mayor de San Marcos (1950-57) (1956), 581-8, database is CAplus.

Various phenols were treated with ο-C₆H₄(CO)₂O to form the corresponding phthaleins (I) which were halogenated to halophthaleins (II). During the formation of I, the temperature must be maintained below 120° to avoid carbonization or volatilization of the reactants. The halogenation must be conducted in the cold under mildly alk. conditions to obtain good yields of II. Iodinated phthaleins lactonize readily.

Anales de la Facultad de Farmacia y Bioquimica, Universidad Nacional Mayor de San Marcos (1950-57) published new progress about 596-01-0. 596-01-0 belongs to benzofurans, auxiliary class Benzofuran,Naphthalene,Alcohol,Ester, name is 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one, and the molecular formula is C28H18O4, Product Details of C28H18O4.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Legradi, L. published the artcileMechanism of adsorption indication. IX. Phthaleins as adsorption indicators, Related Products of benzofurans, the publication is Acta Chimica Academiae Scientiarum Hungaricae (1971), 69(2), 157-61, database is CAplus.

α-Naphtholphthalein is suitable for the argentometric titration of Cl-, Br-, and NCS- ions; phenolphthalein for Br- and I- ions; and thymolphthalein for Cl-, Br-, and I- ions. The mixtures of thymolphthalein and α-naphtholphthalein or phenolphthalein and thymolphthalein are good adsorption indicators at pH 7-9; α-naphtholphthalein can be used without mading the solution alk. The phthalein indicators act on the basis of surface precipitation The Ag salt of the dye was detected on filter paper by a color reaction and was isolated by precipitation

Acta Chimica Academiae Scientiarum Hungaricae published new progress about 596-01-0. 596-01-0 belongs to benzofurans, auxiliary class Benzofuran,Naphthalene,Alcohol,Ester, name is 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one, and the molecular formula is C28H18O4, Related Products of benzofurans.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem