Let`s talk about compound :C8H6O2

Bye, fridends, I hope you can learn more about C8H6O2, If you have any questions, you can browse other blog as well. See you lster.. Computed Properties of C8H6O2

An article Phthalide derivative CD21 ameliorates ischemic brain injury in a mouse model of global cerebral ischemia: involvement of inhibition of NLRP3 WOS:000565183600002 published article about ISCHEMIA/REPERFUSION INJURY; INFLAMMASOME ACTIVATION; LIGUSTILIDE; STROKE; NEUROTOXICITY; PATHWAY; RATS in [Li, Xin; Shi, Meng-Qi; Du, Jun-Rong] Sichuan Univ, Educ Minist, Sichuan Engn Lab Plant Sourced Drug, Dept Pharmacol,Key Lab Drug Targeting & Drug Deli, Chengdu 610041, Peoples R China; [Li, Xin; Shi, Meng-Qi; Du, Jun-Rong] Sichuan Univ, West China Sch Pharm, Sichuan Res Ctr Drug Precis Ind Technol, Chengdu 610041, Peoples R China; [Chen, Chu] Sichuan Acad Chinese Med Sci, Chengdu 610041, Peoples R China in 2020, Cited 43. Computed Properties of C8H6O2. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2

The activation of NLRP3 inflammasome is closely related to ischemic brain injury and inhibition of NLRP3 inflammasome activation may be a new therapeutic strategy for ischemic stroke. Our previous studies showed that ligustilide (LIG) had a dose-dependent neuroprotective effect on various models of cerebral ischemia and dementia in vivo and in vitro. CD21, a kind of phthalide derivative, was modified from LIG. In this study, we established a global cerebral ischemia-reperfusion model in mice by bilateral common carotid artery ligation (2VO), and explored the neuroprotective effect of CD21 and its anti-inflammatory mechanism on cerebral ischemia mice. CD21 significantly improved weight loss, neurobehavioral deficits and neurons loss in hippocampal CA1 and caudate putamen (CPu) subregions, which were induced by 2VO in mice. CD21 significantly inhibited the overactivation of astrocyte and microglia, and decreased the mRNA level of IL-6, TNF-alpha and IL-1 beta. Moreover, CD21 significantly inhibited the activation of TLR4/NF-kappa B signaling pathway mediated by HMGB1 and NLRP3/ASC/Caspase-1 signaling pathway mediated by Cathepsin B, thus inhibiting the activation of NLRP3 inflammasome. Our results demonstrated that CD21 may exert a neuroprotection by inhibiting NLRP3 inflammasome activation after cerebral ischemia. These findings provide a new strategy for the treatment of ischemic stroke.

Bye, fridends, I hope you can learn more about C8H6O2, If you have any questions, you can browse other blog as well. See you lster.. Computed Properties of C8H6O2

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

How did you first get involved in researching 87-41-2

Welcome to talk about 87-41-2, If you have any questions, you can contact Wei, QH; Qin, FF; Ma, QX; Shen, WZ or send Email.. HPLC of Formula: C8H6O2

Recently I am researching about ACTIVATED CARBON; SELECTIVE HYDROGENATION; GRAPHENE OXIDE; NITROGEN; OXIDATION; NITROBENZENE; NANOTUBES; PERFORMANCE; SITES; ELECTRODES, Saw an article supported by the National Key R&D Program of China [2016YFE0203500]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [U1510122]; Foundation of State Key Laboratory of High-efficiency Utilization of Coal and Green Chemical Engineering [2017-K11]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2018M631777]. Published in PERGAMON-ELSEVIER SCIENCE LTD in OXFORD ,Authors: Wei, QH; Qin, FF; Ma, QX; Shen, WZ. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one. HPLC of Formula: C8H6O2

Nitroarenes reduction is an important technology in the industrial production of aminoarenes. In this work, we presented an environment-friendly and low-cost green synthesis route for preparation of oxygen and nitrogen co-doped porous carbon (ONPC) via acid oxidation and alkali activation methods using coal tar- and residual oil-based as starting materials, and the prepared ONPC was employed as metal-free carbon catalyst for nitroarenes reduction to aminoarenes in the presence of hydrazine hydrate. This ONPC catalyst showed much higher catalytic activity as compared to those of un-doped porous carbon (PC), activated carbon (AC) and carbon black, which was attributed to its large surface area and developed pore structure as well as O and N co-doping. Additionally, it also exhibited a versatility in various aromatic nitro-compounds reduction to relative aromatic amines. Experimental results by using model catalysts to simulate different carbons with various oxygen-containing groups proved that carbonyl groups were more favorable for nitrobenzene reduction to aniline. Upon co-doping O and N into PC, the two kinds of introduced species synergistically promoted the catalytic activity of PC. Good performance together with low-cost preparation makes oxygen and nitrogen co-doped porous carbon a potential substitution of supported metal catalyst for nitroarenes reduction. (C) 2018 Elsevier Ltd. All rights reserved.

Welcome to talk about 87-41-2, If you have any questions, you can contact Wei, QH; Qin, FF; Ma, QX; Shen, WZ or send Email.. HPLC of Formula: C8H6O2

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

The Shocking Revelation of C8H6O2

COA of Formula: C8H6O2. Bye, fridends, I hope you can learn more about C8H6O2, If you have any questions, you can browse other blog as well. See you lster.

COA of Formula: C8H6O2. Recently I am researching about PATHWAY CONTRIBUTES; STROKE; INJURY; NEUROGENESIS; LIGUSTILIDE; DEFICITS; KLOTHO, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81072636, 81473219]; Sichuan Science and Technology Programs [2014JY0151, 20185Z0015]; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities; 111 Project of the National Ministry of Education [B18035]. Published in ELSEVIER in AMSTERDAM ,Authors: Gan, YM; Liu, DL; Chen, C; Duan, W; Yang, YX; Du, JR. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one

Microglia can be activated to become the classic phenotype (M1) or alternative phenotype (M2), which play an important role in regulating neuroinflammatory response and tissue repair after ischemic stroke. CD21, a novel phthalide derivative, is a potential neuroprotectant against ischemic brain injury. The present study further investigated the effects of CD21 on post-ischemic microglial polarization and the underlying mechanisms. Transient middle cerebral artery occlusion (tMCAO) was used as a mouse model of ischemic stroke, while BV2 cells stimulated with conditioned medium collected from oxygen-glucose deprivation-treated HT22 cells were used in in vitro ischemic studies. The current results showed that CD21 dose-dependently and significantly improved neurological outcomes in tMCAO mice. Biochemical analyses revealed that CD21 decreased the expression of M1 phenotype markers (CD86, interleukin-1 beta and inducible nitric oxide synthase) and increased the expression of M2 phenotype markers (CD206, interleukin-10 and YM1/2) in both ischemic brain tissues and BV2 cells. Meanwhile, CD21 decreased the production of proinflammatory cytokines (interleukin-1 beta, interleukin-6 and tumor necrosis factor-alpha), promoted the release of the antiinflammatory cytokine (interleukin-10), and enhanced the phosphorylation of adenosine 5′-monophosphate-activated protein kinase (AMPK) in ischemic brain tissue and BV2 cells. Furthermore, the AMPK inhibitor (compound C) reversed these effects of CD21 in BV2 cells. These findings indicate that CD21 alleviates post-ischemic neuroinflammation through induction of microglial M2 polarization that is at least in part medicated by AMPK activation, suggesting that CD21 may be a promising candidate for protecting against ischemic brain injury.

COA of Formula: C8H6O2. Bye, fridends, I hope you can learn more about C8H6O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Some scientific research about 87-41-2

Bye, fridends, I hope you can learn more about C8H6O2, If you have any questions, you can browse other blog as well. See you lster.. Product Details of 87-41-2

Authors Liang, XY; Yu, P; Fu, C; Shen, YC in PERGAMON-ELSEVIER SCIENCE LTD published article about in [Liang, Xiayu; Yu, Peng; Fu, Chen; Shen, Yongcun] Wuhan Univ Technol, Sch Chem Chem Engn & Life Sci, 122 Luoshi Rd, Wuhan 430070, Peoples R China in 2021, Cited 31. Product Details of 87-41-2. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2

A new strategy for the facile synthesis of hydroxyalkylamides through the ring-opening reaction of lactone with amine promoted by dibutyltin acetate was developed. A series of hydroxyalkylamide compounds were obtained and the method was successfully applied to the synthesis of pharmaceutically active molecules tyrosinase inhibitor V and HDAC inhibitor VI via a three-step synthetic pathway. The broad substrate scope, mild reaction conditions and practical application proved the effectiveness, compatibility and practicality of this method. (C) 2021 Elsevier Ltd. All rights reserved.

Bye, fridends, I hope you can learn more about C8H6O2, If you have any questions, you can browse other blog as well. See you lster.. Product Details of 87-41-2

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Search for chemical structures by a sketch :87-41-2

Recommanded Product: 87-41-2. Welcome to talk about 87-41-2, If you have any questions, you can contact Das, UK; Janes, T; Kumar, A; Milstein, D or send Email.

Das, UK; Janes, T; Kumar, A; Milstein, D in [Das, Uttam Kumar; Janes, Trevor; Kumar, Amit; Milstein, David] Weizmann Inst Sci, Dept Organ Chem, IL-76100 Rehovot, Israel; [Kumar, Amit] Univ St Andrews, Sch Chem, St Andrews KY16 9ST, Fife, Scotland published Manganese catalyzed selective hydrogenation of cyclic imides to diols and amines in 2020, Cited 43. Recommanded Product: 87-41-2. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2.

Herein we report the selective hydrogenation of cyclic imides to diols and amines, homogeneously catalyzed for the first time by a complex of an earth-abundant metal, a manganese pincer complex. A plausible catalytic cycle is proposed based on informative mechanistic experiments.

Recommanded Product: 87-41-2. Welcome to talk about 87-41-2, If you have any questions, you can contact Das, UK; Janes, T; Kumar, A; Milstein, D or send Email.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

What Kind of Chemistry Facts Are We Going to Learn About Isobenzofuran-1(3H)-one

Bye, fridends, I hope you can learn more about C8H6O2, If you have any questions, you can browse other blog as well. See you lster.. Quality Control of Isobenzofuran-1(3H)-one

Quality Control of Isobenzofuran-1(3H)-one. Recently I am researching about CELL-CULTURES; IN-VITRO; REGENERATION; QUALITY; DIFFERENTIATION; METABOLISM; PHTHALIDES; INDUCTION; CAPACITY; STRESS, Saw an article supported by the BK21 + Program, the Ministry of Education, Republic of Korea; Korea Institute of Planning and Evaluation for technology in Food, Agriculture, Forestry and Fisheries [116057-03]. Published in ELSEVIER SCIENCE SA in LAUSANNE ,Authors: Adil, M; Ren, XX; Jeong, BR. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one

Cnidium officinale Makino is an important medicinal plant of oriental clinics and is considered as the main source of phthalides, polyphenols, and flavonoids. However, there is no available report regarding the effect of different light colors on the secondary metabolites composition of C. officinale. In this study different light (dark, white, blue, red and red: blue) conditions were arranged to raise callus on MS medium containing 0.5 mg.L-1 of each 2,4-D and BAP. Callus grown in dark condition showed maximum (2.0 g) fresh weight with lower total phenolic and flavonoids contents. Also, in dark condition callus faced higher catalase (CAT) and guaiacol peroxidase (GPX) activities to avoid free radicals. Mix (red: blue) light condition favored the synthesis of phenolics and flavonoids in callus at the cost of higher ascorbate peroxidase (APX) and superoxide dismutase (SOD) enzymes expression. However, DPPH free radical scavenging activity was less variable among the samples from the different light conditions. Interestingly, the HPLC profile showed higher (28.3 mu g.g(-1) DW) phthalide accumulation in dark grown-cultures. Compared to other light conditions, 3-butyledinephthalide accumulation was higher (0.43 mu g-g(-1) DW) in white light-grown callus. These findings suggest that light conditions play an important role in the regulation of in vitro callus growth and synthesis of important medicinal compounds of C. officinale.

Bye, fridends, I hope you can learn more about C8H6O2, If you have any questions, you can browse other blog as well. See you lster.. Quality Control of Isobenzofuran-1(3H)-one

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Discovery of Isobenzofuran-1(3H)-one

Welcome to talk about 87-41-2, If you have any questions, you can contact Liu, YY; Zhao, H; Xie, J; Zou, J; Hu, D; Guo, LD; Chen, GD; Yao, XS; Gao, H or send Email.. Application In Synthesis of Isobenzofuran-1(3H)-one

I found the field of Pharmacology & Pharmacy very interesting. Saw the article New phthalide derivatives from the Biscogniauxia sp. and their activities published in 2019. Application In Synthesis of Isobenzofuran-1(3H)-one, Reprint Addresses Chen, GD; Gao, H (corresponding author), Jinan Univ, Coll Pharm, Inst Tradit Chinese Med & Nat Prod, Guangdong Prov Key Lab Pharmacodynam Constituents, Guangzhou 510632, Guangdong, Peoples R China.. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one

Five new phthalide derivatives, biscogniphthalides A-D (1, 2, 3a/3b, and 4), were isolated from Biscogniauxia sp. (No. 69-8-7-1), along with one related known phthalide (5). Their structures were determined by comprehensive spectroscopic analyses, chemical derivatization, and quantum chemical ECD calculations. In addition, the anti-acetyl cholinesterase, antimicrobial, and anti-a-glucosidase activities of 1-5 were evaluated.

Welcome to talk about 87-41-2, If you have any questions, you can contact Liu, YY; Zhao, H; Xie, J; Zou, J; Hu, D; Guo, LD; Chen, GD; Yao, XS; Gao, H or send Email.. Application In Synthesis of Isobenzofuran-1(3H)-one

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Interesting scientific research on Isobenzofuran-1(3H)-one

HPLC of Formula: C8H6O2. Welcome to talk about 87-41-2, If you have any questions, you can contact Monsigny, L; Thuery, P; Berthet, JC; Cantat, T or send Email.

An article Breaking C-O Bonds with Uranium: Uranyl Complexes as Selective Catalysts in the Hydrosilylation of Aldehydes WOS:000489204000019 published article about RING-OPENING POLYMERIZATION; METAL-FREE; CRYSTAL-STRUCTURE; REDUCTIVE DEPOLYMERIZATION; CARBONYL-COMPOUNDS; ALDOL CONDENSATION; SYMMETRIC ETHERS; CARBOXYLIC-ACIDS; CYCLOTRIMERIZATION; ETHERIFICATION in [Monsigny, Louis; Thuery, Pierre; Berthet, Jean-Claude; Cantat, Thibault] Univ Paris Saclay, CEA Saclay, CNRS, NIMBE,CEA, F-91191 Gif Sur Yvette, France in 2019, Cited 76. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2. HPLC of Formula: C8H6O2

We report herein the possibility to perform the hydrosilylation of carbonyls using actinide complexes as catalysts. While complexes of the uranyl ion [UO2](2+) have been poorly considered in catalysis, we show the potentialities of the Lewis acid [UO2(OTf)(2)] (1) in the catalytic hydrosilylation of a series of aldehydes. [UO2(OTf)(2)] proved to be a very active catalyst affording distinct reduction products depending on the nature of the reductant. With Et3SiH, a number of aliphatic and aromatic aldehydes are reduced into symmetric ethers, while (Pr3SiH)-Pr-i yielded silylated alcohols. Studies of the reaction mechanism led to the isolation of aldehyde/uranyl complexes, [UO2(OTf)(2)(4-Me2N-PhCHO)(3)], [UO2(mu-kappa(2)-OTf)(2)(PhCHO)](n), and [UO2(mu-kappa(2)-OTf(kappa(1)-OTf)(PhCHO)(2)](2), which have been fully characterized by NMR, IR, and single-crystal X-ray diffraction.

HPLC of Formula: C8H6O2. Welcome to talk about 87-41-2, If you have any questions, you can contact Monsigny, L; Thuery, P; Berthet, JC; Cantat, T or send Email.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Why do aromatic interactions matter of compound:Isobenzofuran-1(3H)-one

Welcome to talk about 87-41-2, If you have any questions, you can contact Du, T; Gao, RH; Deng, YF; Wang, C; Zhou, Q; Geng, YH or send Email.. Product Details of 87-41-2

Product Details of 87-41-2. Recently I am researching about CHANNEL ORGANIC SEMICONDUCTORS; PI-CONJUGATED MATERIALS; HIGH-PERFORMANCE; BUILDING-BLOCK; THIOPHENE-S,S-DIOXIDIZED INDOPHENINE; QUINOIDAL OLIGOTHIOPHENES; SIDE-CHAIN; MOLECULES; POLYMERS; ANALOGS, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21774093]; National Key R&D Program of Strategic Advanced Electronic Materials [2016YFB0401100]; Chinese Ministry of Science and TechnologyMinistry of Science and Technology, China. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Du, T; Gao, RH; Deng, YF; Wang, C; Zhou, Q; Geng, YH. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one

A series of 1,3-indandione-terminated pi-conjugated quinoids were synthesized by alkoxide-mediated rearrangement reaction of the respective alkene precursors, followed by air oxidation. This new protocol allows access to quinoidal compounds with variable termini and cores. The resulting quinoids all show LUMO levels below -4.0 eV and molar extinction coefficients above 10(5) L mol(-1) cm(-1). The optoelectronic properties of these compounds can be regulated by tuning the central cores as well as the aryl termini ascribed to the delocalized frontier molecular orbitals over the entire molecular skeleton involving aryl termini. n-Channel organic thin-film transistors with electron mobility of up to 0.38 cm(2) V-1 s(-1) were fabricated, showing the potential of this new class of quinoids as organic semiconductors.

Welcome to talk about 87-41-2, If you have any questions, you can contact Du, T; Gao, RH; Deng, YF; Wang, C; Zhou, Q; Geng, YH or send Email.. Product Details of 87-41-2

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

The Shocking Revelation of C8H6O2

Application In Synthesis of Isobenzofuran-1(3H)-one. Welcome to talk about 87-41-2, If you have any questions, you can contact Backer, BS; Choy, CJ; Davis, AL; Browne, ZS; Berkman, CE or send Email.

Authors Backer, BS; Choy, CJ; Davis, AL; Browne, ZS; Berkman, CE in PERGAMON-ELSEVIER SCIENCE LTD published article about GENERAL-ACID CATALYSIS; NUCLEOPHILIC-ATTACK; HYDROLYSIS; CONJUGATE; RESONANCE; DESIGN; FIELD; OXIDE in [Backer, Brian S.; Choy, Cindy J.; Davis, Austen L.; Browne, Zachery S.; Berkman, Clifford E.] Washington State Univ, Dept Chem, Pullman, WA 99164 USA in 2020, Cited 28. Application In Synthesis of Isobenzofuran-1(3H)-one. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2

We previously described a pH-sensitive phosphoramidate linker scaffold that can be tuned to release amine-containing drugs at various pH values. In these previous studies it was determined that the tunability of this linker was dependent upon the proximity of an acidic group (e.g., carboxylic acid or pyridinium). In this study, we confirmed that the tunability of pH-triggered amine-release was also dependent upon the pK(a) of the proximal acidic group. A series of 2-carboxybenzyl phosphoramidates was prepared in which the pK(a) of the proximal benzoic acid was predictably attenuated by substituents on the benzoate ring consistent with their sigma-values. (C) 2020 Elsevier Ltd. All rights reserved.

Application In Synthesis of Isobenzofuran-1(3H)-one. Welcome to talk about 87-41-2, If you have any questions, you can contact Backer, BS; Choy, CJ; Davis, AL; Browne, ZS; Berkman, CE or send Email.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem