Month: November 2021

An article Synthesis and Anticancer Evaluation of New 1,3,4-Oxadiazole Derivatives WOS:000654444900001 published article about POSSESSING 1,4-BENZODIOXAN MOIETY; BIOLOGICAL EVALUATION; MOLECULAR DOCKING; ANTIPROLIFERATIVE ACTIVITY; CARCINOMA-CELLS; ACID SYNTHESIS; CANCER; DESIGN; INHIBITORS; IDENTIFICATION in [Stecoza, Camelia Elena; Nitulescu, George Mihai; Olaru, Octavian Tudorel] Carol Davila Univ Med & Pharm, Dept Pharmaceut Chem, Fac Pharm, 6 Traian Vuia St, Bucharest 020956, Romania; [Draghici, Constantin; Caproiu, Miron Teodor] Romanian Acad, Costin D Nenitescu Ctr Organ Chem, 202 B Splaiul Independentei, Bucharest 060023, Romania; [Bostan, Marinela; Mihaila, Mirela] Inst Virol, Ctr Immunol Stefan S Nicolau, Bucharest 030304, Romania in 2021, Cited 54. COA of Formula: C8H6O2. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2

In order to develop novel chemotherapeutic agents with potent anticancer activities, a series of new 2,5-diaryl/heteroaryl-1,3,4-oxadiazoles were designed and synthesized. The structures of the new compounds were established using elemental analyses, IR and NMR spectral data. The compounds were evaluated for their anticancer potential on two standardized human cell lines, HT-29 (colon adenocarcinoma) and MDA-MB-231 (breast adenocarcinoma). Cytotoxicity was measured by MTS assay, while cell cycle arrest and apoptosis assays were conducted using a flow cytometer, the results showing that the cell line MDA-MB-231 is more sensitive to the compounds’ action. The results of the predictive studies using the PASS application and the structural similarity analysis indicated STAT3 and miR-21 as the most probable pharmacological targets for the new compounds. The promising effect of compound 3e, 2-[2-(phenylsulfanylmethyl)phenyl]-5-(4-pyridyl)-1,3,4-oxadiazole, especially on the MDA-MB-231 cell line motivates future studies to improve the anticancer profile and to reduce the toxicological risks. It is worth noting that 3e produced a low toxic effect in the D. magna 24 h assay and the predictive studies on rat acute toxicity suggest a low degree of toxic risks.

COA of Formula: C8H6O2. Welcome to talk about 87-41-2, If you have any questions, you can contact Stecoza, CE; Nitulescu, GM; Draghici, C; Caproiu, MT; Olaru, OT; Bostan, M; Mihaila, M or send Email.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

An article Association of electroanalytical and spectrophotometric methods to evaluate the antioxidant activity of isobenzofuranone in primary cultures of hippocampal neurons WOS:000566428200014 published article about PEROXIDE-INDUCED DAMAGE; OXIDATIVE STRESS; 3-SUBSTITUTED ISOCOUMARINS; CELLS; CHEMISTRY in [Teixeira, Aniely dos Reis; Ribeiro, Iara Mariana Lellis; Oliveira, Laser Antonio Machado; Nogueira, Katiane de Oliveira Pinto Coelho] Univ Fed Ouro Preto, Dept Biol Sci, Neurobiol & Biomat Lab, Ouro Preto, MG, Brazil; [Teixeira, Robson Ricardo; Pereira, Wagner Luiz] Univ Fed Vicosa, Dept Chem, Vicosa, MG, Brazil; [Manhabosco, Taise Matte; de Brito, Ana Carolina Ferreira] Univ Fed Ouro Preto, Dept Phys, REDEMAT, Ouro Preto, MG, Brazil in 2020, Cited 52. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2. Recommanded Product: 87-41-2

The isobenzofuran-1(3H)-ones (phthalides) exhibit various biological activities, including antioxidant activity on reactive oxygen species (ROS). An excess of ROS that cannot be naturally contained by cellular enzymatic systems is called redox imbalance, which damage cell membranes, proteins, and DNA, thereby possibly triggering neuronal death in several neurodegenerative diseases. Considering our ongoing efforts to find useful compounds to control redox imbalance, herein we evaluated the antioxidant activity of two phtalides (compounds 3 and 4), using primary cultures of hippocampal neurons. Spectrophotometric assays showed that compound 3 significantly reduced (p <= 0.05) ROS levels and lipid peroxidation compared to the control treatment, while compound 4 was unable at any of the tested concentrations. Despite their structural similarity, these compounds behave differently in the intracellular environment, which was reliably corroborated by the determination of oxidation potentials via cyclic voltammetry. It was demonstrated that compound 3 presents a lower oxidation potential. The combination of the mentioned methods allowed us to find a strong correlation between the chemical structure of compounds and their biological effects. Taking together, the results indicate that compound 3 presents desirable characteristics to act as a candidate pharmacological agent for use in the prevention and treatment of neurodegenerative diseases. Recommanded Product: 87-41-2. Welcome to talk about 87-41-2, If you have any questions, you can contact Teixeira, AD; Teixeira, RR; Ribeiro, IML; Pereira, WL; Manhabosco, TM; de Brito, ACF; Oliveira, LAM; Nogueira, KDPC or send Email.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

I found the field of Chemistry very interesting. Saw the article Modular Synthetic Approach to Silicon-Rhodamine Homologues and Analogues via Bis-aryllanthanum Reagents published in 2021. HPLC of Formula: C8H6O2, Reprint Addresses Butkevich, AN (corresponding author), Max Planck Inst Med Res, Dept Opt Nanoscopy, D-69120 Heidelberg, Germany.. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one

A modular synthetic approach toward diverse analogues of the far-red fluorophore silicon-rhodamine (SiR), based on a regioselective double nucleophilic addition of aryllanthanum reagents to esters, anhydrides, and lactones, is proposed. The reaction has improved functional group tolerance and represents a unified strategy toward cell-permeant, spontaneously blinking, and photoactivatable SiR fluorescent labels. In tandem with Pd-catalyzed hydroxy- or aminocarbonylation, it serves a streamlined synthetic pathway to a series of validated live-cell-compatible fluorescent dyes.

HPLC of Formula: C8H6O2. Welcome to talk about 87-41-2, If you have any questions, you can contact Butkevich, AN or send Email.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Formula: C8H6O2. In 2020 CATALYSTS published article about NONTHERMAL PLASMA; MODEL-COMPOUND; BIOMASS GASIFICATION; NAPHTHALENE DECOMPOSITION; DISCHARGE CHARACTERISTICS; HETEROGENEOUS CATALYSIS; TOTAL OXIDATION; CARBON-DIOXIDE; PRODUCER GAS; CO2 in [Cimerman, Richard; Cibikova, Maria; Hensel, Karol] Comenius Univ, Fac Math Phys & Informat, Dept Astron Phys Earth & Meteorol, Mlynska Dolina F2, Bratislava 84248, Slovakia; [Satrapinskyy, Leonid] Comenius Univ, Fac Math Phys & Informat, Dept Expt Phys, Mlynska Dolina F2, Bratislava 84248, Slovakia in 2020, Cited 108. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2.

Plasma catalysis has been utilized in many environmental applications for removal of various hydrocarbons including tars. The aim of this work was to study the tars removal process by atmospheric pressure DBD non-thermal plasma generated in combination with packing materials of various composition and catalytic activity (TiO2, Pt/gamma Al2O3, BaTiO3, gamma Al2O3, ZrO2, glass beads), dielectric constant (5-4000), shape (spherical and cylindrical pellets and beads), size (3-5 mm in diameter, 3-8 mm in length), and specific surface area (37-150 m(2)/g). Naphthalene was chosen as a model tar compound. The experiments were performed at a temperature of 100 degrees C and a naphthalene initial concentration of approx. 3000 ppm, i.e., under conditions that are usually less favorable to achieve high removal efficiencies. For a given specific input energy of 320 J/L, naphthalene removal efficiency followed a sequence: TiO2 > Pt/gamma Al2O3 > ZrO2 > gamma Al2O3 > glass beads > BaTiO3 > plasma only. The efficiency increased with the increasing specific surface area of a given packing material, while its shape and size were also found to be important. By-products of naphthalene decomposition were analyzed by means of FTIR spectrometry and surface of packing materials by SEM analysis.

Formula: C8H6O2. Welcome to talk about 87-41-2, If you have any questions, you can contact Cimerman, R; Cibikova, M; Satrapinskyy, L; Hensel, K or send Email.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

I found the field of Chemistry; Crystallography; Materials Science very interesting. Saw the article Cu(I)-Based Metal-Organic Frameworks as Efficient and Recyclable Heterogeneous Catalysts for Aqueous-Medium C-H Oxidation published in 2019. Formula: C8H6O2, Reprint Addresses Wu, J; Hou, HW (corresponding author), Zhengzhou Univ, Coll Chem & Mol Engn, Zhengzhou 450001, Henan, Peoples R China.. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one

The enantioselective transformation of ubiquitous C-H bonds into valuable C=O bonds offers an efficient synthetic approach to construct carbonyl functionalized molecules. However, the grand obstacles in the reaction are the selectivity issues and side reactions under the harsh reaction conditions. In order to overcome the limits, two Cu(I)-based MOFs {(NEt4)(0.5)[Cu-3 (TTPB)(0.75) (CN)(0.5)(H2O)]center dot H2O}(n) (1) and {[Cu-2 (TTPB)(0.5)]center dot DMF center dot 2H(2)O}(n) (2) were synthesized (H-4 TTPB = 5,5′ – (4′,5′ -bis (4- (1H-tetrazol-5-yl)phenyl)- [1,1′ :2′,1 ”-terphenyl]-4,4 ”-diyl) bis(1H-tetrazole)) under hydrothermal conditions with (triethylamine (TEA) and ethyldiisopropylamine (DIPEA) as structure-directing agents, respectively. Of these, 1 shows an anionic three-dimensional (3D) framework composed of two kinds of cagelike micropores with 7 X 17 angstrom and 10 x 17 angstrom, respectively. In comparison, 2 exhibits a 3D framework with open channels (14 x 8 angstrom). The stability studies showed that the crystallinity of 1 and 2 could remain in a series of organic solvents (ethanol, N,N-dimethylformamide, chloroform, dioxane, toluene) and acid and alkali aqueous solutions (pH = 1-13) at room temperature for 48 h. 1 and 2 with coordinatively unsaturated Cu(I) sites were applied as heterogeneous catalysts for the oxidation of arylacycloalkanes in aqueous medium and exhibited excellent catalytic activities, selectivities, and recyclabilities. Moreover, free-radical reaction mechanism and reversible valence-tautomeric conversions of central copper were confirmed during the process by control experiment.

Formula: C8H6O2. Welcome to talk about 87-41-2, If you have any questions, you can contact Gao, K; Huang, C; Yang, YS; Li, H; Wu, J; Hou, HW or send Email.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Recently I am researching about METAL-FREE REDUCTION; FRUSTRATED LEWIS PAIRS; H BOND ACTIVATION; CARBONYL-COMPOUNDS; CARBOXYLIC-ACIDS; IRIDIUM(III) METALLACYCLES; HOMOGENEOUS CATALYSIS; UNSYMMETRICAL ETHERS; SELECTIVE REDUCTION; SI-H, Saw an article supported by the University of Lille; CNRSCentre National de la Recherche Scientifique (CNRS)European Commission; Chevreul Institute (FR 2638); Ministere de l’Enseignement Superieur et de la RechercheEstonian Research CouncilEuropean Commission; Region Hauts-de-FranceRegion Hauts-de-France; FEDEREuropean Commission; European UnionEuropean Commission; European Regional Development Fund (ERDF)European Commission; Hauts de France Regional Council [17003781]; Metropole Europeenne de Lille [2016_ESR_05]; Pasteur Institute of Lille; Lille University; French CNRSCentre National de la Recherche Scientifique (CNRS); [2017-R3-CTRL-Phase 1]. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Rysak, V; Dixit, R; Trivelli, X; Merle, N; Agbossou-Niedercorn, F; Vanka, K; Michon, C. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one. Name: Isobenzofuran-1(3H)-one

We report the catalytic and transition metal-free reductive deoxygenation of esters to ethers through the use of a hydrosilane and a fluorinated borate BArF salt as a catalyst. Experimental and theoretical studies support the role of noncovalent interactions between the fluorinated catalyst, the hydrosilane and the ester substrate in the reaction mechanism.

Name: Isobenzofuran-1(3H)-one. Welcome to talk about 87-41-2, If you have any questions, you can contact Rysak, V; Dixit, R; Trivelli, X; Merle, N; Agbossou-Niedercorn, F; Vanka, K; Michon, C or send Email.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Authors Butkevich, AN in AMER CHEMICAL SOC published article about FLUORESCENT-PROBES; CELL; FLUOROPHORE; MICROSCOPY in [Butkevich, Alexey N.] Max Planck Inst Med Res, Dept Opt Nanoscopy, D-69120 Heidelberg, Germany in 2021, Cited 41. HPLC of Formula: C8H6O2. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2

A modular synthetic approach toward diverse analogues of the far-red fluorophore silicon-rhodamine (SiR), based on a regioselective double nucleophilic addition of aryllanthanum reagents to esters, anhydrides, and lactones, is proposed. The reaction has improved functional group tolerance and represents a unified strategy toward cell-permeant, spontaneously blinking, and photoactivatable SiR fluorescent labels. In tandem with Pd-catalyzed hydroxy- or aminocarbonylation, it serves a streamlined synthetic pathway to a series of validated live-cell-compatible fluorescent dyes.

HPLC of Formula: C8H6O2. Welcome to talk about 87-41-2, If you have any questions, you can contact Butkevich, AN or send Email.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

I found the field of Chemistry very interesting. Saw the article Cubane Electrochemistry: Direct Conversion of Cubane Carboxylic Acids to Alkoxy Cubanes Using the Hofer-Moest Reaction under Flow Conditions published in 2020. Computed Properties of C8H6O2, Reprint Addresses Linclau, B; Brown, RCD (corresponding author), Univ Southampton, Sch Chem, Southampton SO17 1BJ, Hants, England.. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one

The highly strained cubane system is of great interest as a scaffold and rigid linker in both pharmaceutical and materials chemistry. The first electrochemical functionalisation of cubane by oxidative decarboxylative ether formation (Hofer-Moest reaction) was demonstrated. The mild conditions are compatible with the presence of other oxidisable functional groups, and the use of flow electrochemical conditions allows straightforward upscaling.

Computed Properties of C8H6O2. Welcome to talk about 87-41-2, If you have any questions, you can contact Collin, DE; Folgueiras-Amador, AA; Pletcher, D; Light, ME; Linclau, B; Brown, RCD or send Email.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Recently I am researching about C-H ALKYNYLATION; BRONSTED ACID; AMINE OXIDASE; DERACEMISATION; RACEMATE, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21971148]; Shenzhen Special Funds [JCYJ20190807093805572]. Published in ELSEVIER SCIENCE INC in NEW YORK ,Authors: Chen, XH; Zhao, R; Liu, ZQ; Sun, ST; Ma, YG; Liu, QY; Sun, X; Liu, L. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one. HPLC of Formula: C8H6O2

Chiral alpha-substituted 1,3-dihydroisobenzofurans are key scaffolds in a number of bioactive natural products and synthetic pharmaceuticals. However, catalytic asymmetric approaches have been rarely developed. Here, a redox deracemization technology is adopted to address the catalytic asymmetric synthesis. A broad range of alpha-aryl substituted 1,3-dihydroisobenzofurans are effectively deracemized in high efficiency with excellent ee. alpha-Alkynyl substituted ethers were also compatible with the deracemization technology. (c) 2021 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.

HPLC of Formula: C8H6O2. Welcome to talk about 87-41-2, If you have any questions, you can contact Chen, XH; Zhao, R; Liu, ZQ; Sun, ST; Ma, YG; Liu, QY; Sun, X; Liu, L or send Email.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

SDS of cas: 87-41-2. I found the field of Chemistry very interesting. Saw the article Breaking C-O Bonds with Uranium: Uranyl Complexes as Selective Catalysts in the Hydrosilylation of Aldehydes published in 2019, Reprint Addresses Berthet, JC; Cantat, T (corresponding author), Univ Paris Saclay, CEA Saclay, CNRS, NIMBE,CEA, F-91191 Gif Sur Yvette, France.. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one.

We report herein the possibility to perform the hydrosilylation of carbonyls using actinide complexes as catalysts. While complexes of the uranyl ion [UO2](2+) have been poorly considered in catalysis, we show the potentialities of the Lewis acid [UO2(OTf)(2)] (1) in the catalytic hydrosilylation of a series of aldehydes. [UO2(OTf)(2)] proved to be a very active catalyst affording distinct reduction products depending on the nature of the reductant. With Et3SiH, a number of aliphatic and aromatic aldehydes are reduced into symmetric ethers, while (Pr3SiH)-Pr-i yielded silylated alcohols. Studies of the reaction mechanism led to the isolation of aldehyde/uranyl complexes, [UO2(OTf)(2)(4-Me2N-PhCHO)(3)], [UO2(mu-kappa(2)-OTf)(2)(PhCHO)](n), and [UO2(mu-kappa(2)-OTf(kappa(1)-OTf)(PhCHO)(2)](2), which have been fully characterized by NMR, IR, and single-crystal X-ray diffraction.

SDS of cas: 87-41-2. Welcome to talk about 87-41-2, If you have any questions, you can contact Monsigny, L; Thuery, P; Berthet, JC; Cantat, T or send Email.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem