Day: November 9, 2021

Fang, X; Ma, Q; Zhang, KX; Yao, SY; Feng, Y; Jin, YS; Liang, S in [Fang, Xin; Ma, Qiang; Feng, Yi; Liang, Shuang] Shanghai Univ Tradit Chinese Med, Innovat Res Inst Tradit Chinese Med, Shanghai 201203, Peoples R China; [Zhang, Kai-Xia; Yao, Song-Yun; Jin, Yong-Sheng] Second Mil Med Univ, Sch Pharm, Shanghai 200433, Peoples R China published Synthesis of phthalide derivatives and evaluation on their antiplatelet aggregation and antioxidant activities in 2020, Cited 25. Safety of Isobenzofuran-1(3H)-one. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2.

As part of our continuing efforts to discover structurally interesting bioactive phthalide derivatives, 23 of them with a structure incorporating thiophen or halogens were designed and synthesized, 17 of which are previously unreported. In vitro antiplatelet aggregation activity screening showed that 14b could significantly inhibit platelet aggregation induced by arachidonic acid, compared with edaravone (p < 0.01). Meanwhile, oxidative damage models using SH-SY5Y and PC12 cells induced by H2O2 were built to evaluate the antioxidant activity of the phthalide derivatives. In SH-SY5Y cells, compared with aspirin, 1a significantly increased the relative cell survival rate (p < 0.05). Compared with edaravone, 1a (p < 0.01) and 15b (p < 0.05) significantly increased the relative cell survival rate. In PC12 cells, 1a (p < 0.01), 15b (p < 0.01), and 12a (p < 0.05) remarkably increased the cell survival rate compared with edaravone. The present study identified lead structures to develop potential anti-ischemic stroke agents. Welcome to talk about 87-41-2, If you have any questions, you can contact Fang, X; Ma, Q; Zhang, KX; Yao, SY; Feng, Y; Jin, YS; Liang, S or send Email.. Safety of Isobenzofuran-1(3H)-one

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Authors Zhou, MX; Gridneva, T; Zhang, ZF; He, ED; Liu, YG; Zhang, WB in WILEY-V C H VERLAG GMBH published article about ENANTIOSELECTIVE C-ACYLATION; SECONDARY ALCOHOLS; DERIVATIVES in [Zhou, Muxing; Zhang, Zhenfeng; He, Ende; Liu, Yangang; Zhang, Wanbin] Shanghai Jiao Tong Univ, Shanghai Key Lab Mol Engn Chiral Drugs, Sch Pharm, 800 Dongchuan Rd, Shanghai 200240, Peoples R China; [Gridneva, Tatiana; Zhang, Wanbin] Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, Frontiers Sci Ctr Transformat Mol, 800 Dongchuan Rd, Shanghai 200240, Peoples R China in 2021, Cited 47. Name: Isobenzofuran-1(3H)-one. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2

Utilizing a chiral bicyclic imidazole organocatalyst and adopting a continuous injection process, an alternative route has been developed for the efficient synthesis of chiral phthalidyl ester prodrugs via dynamic kinetic resolution of 3-hydroxyphthalides through enantioselective acylation (up to 99 % ee). The computational studies suggest a general base catalytic mechanism differing from the widely accepted nucleophilic catalytic mechanism. The structure analysis of the key transition states shows that the CH-pi interactions and not the previously considered cation/pi-pi interactions between the catalyst and substrate is the dominant factor giving rise to the observed stereocontrol.

Welcome to talk about 87-41-2, If you have any questions, you can contact Zhou, MX; Gridneva, T; Zhang, ZF; He, ED; Liu, YG; Zhang, WB or send Email.. Name: Isobenzofuran-1(3H)-one

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

An article Efficient synthesis of N ‘-benzylidene-2-hydroxymethylbenzohydrazides from the one-pot reaction of phthalide, hydrazine and aldehydes WOS:000486518900003 published article about BIOLOGICAL EVALUATION; DERIVATIVES; HYDRAZONES; DESIGN in [Alifu, Zulipiye; Nizhamu, Maijidan; Ablajan, Keyume] Xinjiang Univ, Key Lab Oil & Gas Fine Chem, Minist Educ & Xinjiang Uyghur Autonomous Reg, Coll Chem & Chem Engn, Urumqi 830046, Peoples R China in 2019, Cited 22. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2. Category: benzofurans

We report an efficient, catalyst-free, one-pot synthesis of (E)-N ‘-benzylidene-2-(hydroxymethyl)benzohydrazide derivatives by the one-pot reaction of phthalide, hydrazine hydrate and aldehyde. Advantages of this synthetic approach include mild reaction conditions and environmentally friendly nature, and the ability to provide a wide range of desired compounds in moderate to excellent yields. Graphic abstract Here we introduce a green and efficient one-pot three-component protocol for the synthesis of (E)-N ‘-benzylidene-2-(hydroxymethyl)benzohydrazide derivatives in ethanol without any catalyst. [GRAPHICS] .

Welcome to talk about 87-41-2, If you have any questions, you can contact Alifu, Z; Nizhamu, M; Ablajan, K or send Email.. Category: benzofurans

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Recommanded Product: 87-41-2. Gan, YM; Liu, DL; Chen, C; Duan, W; Yang, YX; Du, JR in [Gan, Yu-Miao; Liu, Dong-Ling; Yang, Yu-Xin; Du, Jun-Rong] Sichuan Univ, Key Lab Drug Targeting & Drug Delivery Syst, Educ Minist & Sichuan Prov, West China Sch Pharm,Dept Pharmacol,Sichuan Engn, Chengdu 610041, Peoples R China; [Gan, Yu-Miao; Liu, Dong-Ling; Yang, Yu-Xin; Du, Jun-Rong] Sichuan Univ, Sichuan Res Ctr Drug Precis Ind Technol, West China Sch Pharm, Chengdu 610041, Peoples R China; [Chen, Chu] Sichuan Acad Chinese Med Sci, Sichuan Prov Key Lab Qual & Innovat Res Chinese M, Chengdu 610041, Peoples R China; [Duan, Wei] Deakin Univ, Sch Med, Waurn Ponds, Vic, Australia; [Duan, Wei] Deakin Univ, Ctr Mol & Med Res, Waurn Ponds, Vic, Australia; [Yang, Yu-Xin] PRIVIS TECHNOL CO LTD, Chengdu 610041, Peoples R China published Phthalide derivative CD21 alleviates cerebral ischemia-induced neuroinflammation: Involvement of microglial M2 polarization via AMPK activation in 2020, Cited 47. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2.

Microglia can be activated to become the classic phenotype (M1) or alternative phenotype (M2), which play an important role in regulating neuroinflammatory response and tissue repair after ischemic stroke. CD21, a novel phthalide derivative, is a potential neuroprotectant against ischemic brain injury. The present study further investigated the effects of CD21 on post-ischemic microglial polarization and the underlying mechanisms. Transient middle cerebral artery occlusion (tMCAO) was used as a mouse model of ischemic stroke, while BV2 cells stimulated with conditioned medium collected from oxygen-glucose deprivation-treated HT22 cells were used in in vitro ischemic studies. The current results showed that CD21 dose-dependently and significantly improved neurological outcomes in tMCAO mice. Biochemical analyses revealed that CD21 decreased the expression of M1 phenotype markers (CD86, interleukin-1 beta and inducible nitric oxide synthase) and increased the expression of M2 phenotype markers (CD206, interleukin-10 and YM1/2) in both ischemic brain tissues and BV2 cells. Meanwhile, CD21 decreased the production of proinflammatory cytokines (interleukin-1 beta, interleukin-6 and tumor necrosis factor-alpha), promoted the release of the antiinflammatory cytokine (interleukin-10), and enhanced the phosphorylation of adenosine 5′-monophosphate-activated protein kinase (AMPK) in ischemic brain tissue and BV2 cells. Furthermore, the AMPK inhibitor (compound C) reversed these effects of CD21 in BV2 cells. These findings indicate that CD21 alleviates post-ischemic neuroinflammation through induction of microglial M2 polarization that is at least in part medicated by AMPK activation, suggesting that CD21 may be a promising candidate for protecting against ischemic brain injury.

Welcome to talk about 87-41-2, If you have any questions, you can contact Gan, YM; Liu, DL; Chen, C; Duan, W; Yang, YX; Du, JR or send Email.. Recommanded Product: 87-41-2

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

SDS of cas: 87-41-2. I found the field of Chemistry very interesting. Saw the article Peroxydisulfate-Mediated Transition-Metal-Free Oxidative C(sp(3))-H Bond Lactonization published in 2019, Reprint Addresses Nozawa-Kumada, K; Kondo, Y (corresponding author), Tohoku Univ, Grad Sch Pharmaceut Sci, Aoba Ku, 6-3 Aoba, Sendai, Miyagi 9808578, Japan.. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one.

An inexpensive, powerful, and eco-friendly method for transition-metal-free oxidative C(sp(3))-H bond lactonization was developed using sodium peroxydisulfate as the sole oxidant. The cyclization of 2-alkylbenzoic acids containing a primary, secondary or tertiary carbon at the benzylic position proceeded smoothly, affording a variety of lactone derivatives. Furthermore, various functional groups such as halogen, cyano, nitro and hydroxy groups were tolerated under the reaction conditions.

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Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

In 2019 FITOTERAPIA published article about ENANTIOMERIC DERIVATIVES; ABSOLUTE-CONFIGURATION; DILIGUSTILIDE; UMBELLIFERAE in [Wei, Qian; Yang, Jianbo; Li, Li; Su, Yalun; Wang, Aiguo] Chinese Acad Med Sci, Peking Union Med Coll, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China; [Yang, Jianbo] Natl Inst Food & Drug Control, Inst Control Chinese Tradit Med & Ethn Med, Beijing 100050, Peoples R China in 2019, Cited 21. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2. Product Details of 87-41-2

Five new phthalide dimers, chaxiongnolides C-G (1-5), the two enantiomers of riligustilide (6a and 6b) and tokinolide B (7) were isolated from the aerial parts of Ligusticum sinense Oliv cv. Chaxiong. The structures of 1-5 were elucidated through extensive spectroscopic analysis, and the relative configurations of compounds 2 and 3 were further confirmed by an X-ray diffraction experiment. The absolute configurations of 1-3 were assigned by comparing calculated and experimental ECD spectra. The ECD exciton chirality method was used to confirm the absolute configurations of compounds 4, 5, 6a and 6b. Compounds 1-3 are the first dimeric phthalides to be reported that are comprising a sedanolide unit. The compounds were evaluated in vitro for their cytotoxic activity against select human cell lines.

Welcome to talk about 87-41-2, If you have any questions, you can contact Wei, Q; Yang, JB; Li, L; Su, YL; Wang, AG or send Email.. Product Details of 87-41-2

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

In 2019 CHINESE CHEM LETT published article about ONE-POT SYNTHESIS; O-PHTHALALDEHYDE; HYDROGENATION; DOMINO; ALCOHOLS; SOLVENT; ESTERS; COMPLEXES; HYDRIDE; LIGANDS in [Liu, Bin; Zhou, Xigeng] Fudan Univ, Dept Chem, Shanghai Key Lab Mol Catalysis & Innovat Mat, Shanghai 200433, Peoples R China; [Liu, Bin] Technol Res Insititute Shanghai Huayi Grp Co, Shanghai 200241, Peoples R China in 2019, Cited 54. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2. Safety of Isobenzofuran-1(3H)-one

An efficient method for preparation of substituted 1,2-phenylenedimethanols and aliphatic 1,4-diols that are valuable intermediates in organic synthesis, has been developed by the base-promoted reduction of isobenzofuran-1(3H)-ones and y-lactones with silane under mild conditions. Compared with traditional procedures using stoichiometric amounts of metal hydrides and alkyl reductants, the present method avoids the use of sensitive reagents and is operationally simple and a broad variety of functional groups are tolerated. (C) 2018 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.

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Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Safety of Isobenzofuran-1(3H)-one. Recently I am researching about RESAZURIN, Saw an article supported by the Thailand Research Fund (TRF)Thailand Research Fund (TRF) [RSA6280019]; National Center for Genetic Engineering and Biotechnology (BIOTEC grant) [P19-50917]. Published in ELSEVIER in AMSTERDAM ,Authors: Intaraudom, C; Punyain, W; Bunbamrung, N; Dramae, A; Boonruangprapa, T; Pittayakhajonwut, P. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one

Fourteen new compounds including thirteen drimane – phthalide derivatives (fendlerals A – C, fendlerins A – D, fendlerols A – B, fendleric acids A – C, fendlerinine G) and one terphenyl derivative (fendleryl E) along with eight known compounds, fendlerinine A, rickenyls C – D, fendleryls C – D, atromentin, tetramethyl atromentin, and ( +/- )-microsphaerophthalide F, were isolated from the wood fungus Hypoxylon fendleri BCC32408. Compared with the prior work, the results indicated the agitation effect on the production of bioactive drimane – phthalides. The chemical structures were determined based upon spectroscopic analyses and the absolute configurations were verified by comparison of the ECD spectral data with the calculated ECD spectra of the related compounds. Compounds 1-3 exhibited antimicrobial activity against Plasmodium falciparum (IC50 4.15-4.39 mu M), Colletotrichum capsici (MIC 6.25-12.5 mu g/mL), and Bacillus cereus (MIC 1.56-3.13 mu g/mL). All tested compounds displayed broad cytotoxicity against cancerous (MCF-7, KB, and NCI-H187) and non-cancerous (Vero) cells.

Safety of Isobenzofuran-1(3H)-one. Bye, fridends, I hope you can learn more about C8H6O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Name: Isobenzofuran-1(3H)-one. In 2020 ACS CATAL published article about ASYMMETRIC BINARY ACID; 3-SUBSTITUTED PHTHALIDES; TRANSFER HYDROGENATION; RELAY CATALYSIS; TRANSFORMATION; DERIVATIVES; FUSCINARIN; CHEMISTRY; ACETALS; ETHERS in [Pan, Yu-Liang; Zheng, Han-Liang; Wang, Jie; Yang, Chen; Li, Xin; Cheng, Jin-Pei] Nankai Univ, State Key Lab Elementoorgan Chem, Coll Chem, Tianjin 300071, Peoples R China in 2020, Cited 81. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2.

Phthalides as the crucial core skeletons are found extensively in natural products and biological active molecules. Herein we disclose an asymmetric allylation of 3-hydroxyisoben-zofuran-1(3H)-ones with boron allylation reagents to construct chiral phthalide derivatives. The simple Bi(OAc)(3)/chiral phosphoric acid catalytic system proves to be efficient in this method, delivering the desired chiral 3-allylisobenzofuran-1(3H)-ones in good yields (up to 99%) and high enantioselectivities (up to 99.5:0.5 e.r.) under mild conditions. The large-scale reaction and diverse transformations of products to various scaffolds with potential biological activities render it more attractive. Moreover, the mechanism was preliminarily explored by control reactions, mass spectrometry, deuterium experiment, and DFT calculations.

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Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

HPLC of Formula: C8H6O2. In 2019 J ORG CHEM published article about CATALYZES ALDOL-CONDENSATIONS; 2,3-DIMETHYLENEBUTADIENE DIANION; CONVENIENT SYNTHESIS; MOLECULAR-STRUCTURE; EFFICIENT SYNTHESIS; PHOTO-DIMERIZATION; CRYSTAL-STRUCTURE; ISOBENZOFURAN; PHOTOCHEMISTRY; 9-TERT-BUTYLANTHRACENE in [Geiger, Thomas; Haupt, Anne; Bettinger, Holger F.] Eberhard Karls Univ Tubingen, Inst Organ Chem, Morgenstelle 18, D-72076 Tubingen, Germany; [Maichle-Moessmer, Caecilia; Schrenk, Claudio; Schnepf, Andreas] Eberhard Karls Univ Tubingen, Inst Anorgan Chem, Morgenstelle 18, D-72076 Tubingen, Germany in 2019, Cited 84. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2.

There is increased evidence that the effect of bulky groups in organic, organometallic, and inorganic chemistry is not only repulsive but can be attractive because of London dispersion interactions. The influence of the size of primary alkyl substituents in 2- ‘ and 2,3-positions of anthracenes on the diastereoselectivity (anti vs syn dimer) of the [pi(4s) + pi(4s)] photoinduced dimerization is investigated. The synthesis of the anthracene derivatives was achieved by Suzuki-Miyaura reaction of 2,3-dibromoanthracene with alkylboronic acids as well as by reduction of anthraquinones that were obtained from 2,3-disubstituted 1,3-butadienes and naphthoquinone followed by dehydrogenation. The mixtures of dianthracene isomers were analyzed with respect to the anti/syn-ratio of the products by X-ray crystallography and nuclear Overhauser effect spectroscopy. While for the 2,3-dimethylanthracene the anti and syn isomers were formed in equal amounts, the anti dimers are the major products in all other cases. A linear correlation (R-2 = 0.98) between the steric size (Charton parameter) and the isomeric ratio suggests that the selectivity is dominated by classical repulsive steric effects. An exception is the iso-butyl substituent that produces an increased amount of the syn isomer. It is suggested that this is due to an exalted effect of London dispersion interactions.

HPLC of Formula: C8H6O2. Bye, fridends, I hope you can learn more about C8H6O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem