Day: November 3, 2021

Name: Isobenzofuran-1(3H)-one. Recently I am researching about ONE-POT SYNTHESIS; ARYLDIAZONIUM SALTS; EXPEDIENT SYNTHESIS; FLUORESCENCE; PET; CHEMISTRY; DYES; DERIVATIVES; MONOXIDE; DESIGN, Saw an article supported by the Ministere de l’Enseignement et de la Recherche; French Agence Nationale de la RechercheFrench National Research Agency (ANR) [ANR-15-CE18-0015-01]; Investments for the Future Program [ANR-10-LABX-57]; CESAMO [ISM UMR 5255]. Published in PERGAMON-ELSEVIER SCIENCE LTD in OXFORD ,Authors: Christine, T; Tabey, A; Cornilleau, T; Fouquet, E; Hermange, P. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one

Aiming the faster development from bench to bedside of new potential tracers, multimodal tracers for positron emission tomography (PET) and optical imaging (OI) have emerged as a very promising tool. Indeed, they combine the simplicity of use of optical techniques for in vitro/in vivo pre-clinical studies with the various clinical possibilities offered by PET imaging using their radioactive versions. In this context, the preparation of new tags detectable by fluorescence imaging and potentially suitable for PET imaging after a last-step C-11-labeling of the corresponding precursor has been investigated. Various designs and syntheses were explored by linking o-iodobenzyl alcohols and tetramethyl-BODIPY moieties together. Among them, the most promising structure was produced in 30% yield over five steps from a commercially available and inexpensive starting material. (C) 2019 Elsevier Ltd. All rights reserved.

Name: Isobenzofuran-1(3H)-one. Welcome to talk about 87-41-2, If you have any questions, you can contact Christine, T; Tabey, A; Cornilleau, T; Fouquet, E; Hermange, P or send Email.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

I found the field of Chemistry very interesting. Saw the article Enantioselective Allylation of Oxocarbenium Ions Catalyzed by Bi(OAc)(3)/Chiral Phosphoric Acid published in 2020. Name: Isobenzofuran-1(3H)-one, Reprint Addresses Li, X (corresponding author), Nankai Univ, State Key Lab Elementoorgan Chem, Coll Chem, Tianjin 300071, Peoples R China.. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one

Phthalides as the crucial core skeletons are found extensively in natural products and biological active molecules. Herein we disclose an asymmetric allylation of 3-hydroxyisoben-zofuran-1(3H)-ones with boron allylation reagents to construct chiral phthalide derivatives. The simple Bi(OAc)(3)/chiral phosphoric acid catalytic system proves to be efficient in this method, delivering the desired chiral 3-allylisobenzofuran-1(3H)-ones in good yields (up to 99%) and high enantioselectivities (up to 99.5:0.5 e.r.) under mild conditions. The large-scale reaction and diverse transformations of products to various scaffolds with potential biological activities render it more attractive. Moreover, the mechanism was preliminarily explored by control reactions, mass spectrometry, deuterium experiment, and DFT calculations.

Name: Isobenzofuran-1(3H)-one. Welcome to talk about 87-41-2, If you have any questions, you can contact Pan, YL; Zheng, HL; Wang, J; Yang, C; Li, X; Cheng, JP or send Email.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

HPLC of Formula: C8H6O2. In 2020 SCI CHINA CHEM published article about CATALYZED ASYMMETRIC HYDROGENATION; MOLECULAR-STRUCTURE; COORDINATION; COMPLEXES; PHOSPHORAMIDITE; DERIVATIVES; COMPOUND; LIGANDS; KETONES; ACIDS in [Yu, Chang-Bin; Wang, Heng-Ding; Song, Bo; Shen, Hong-Qiang; Fan, Hong-Jun; Zhou, Yong-Gui] Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Peoples R China; [Wang, Heng-Ding] Univ Chinese Acad Sci, Beijing 100049, Peoples R China in 2020, Cited 57. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2.

For the metal-catalyzed asymmetric hydrogenation of alpha-substituted ketones, cis reductive products are generally obtained due to steric hindrance of substituents. Herein, an unprecedented trans reductive products were observed in palladium-catalyzed hydrogenative desymmetrization of cyclic and acyclic 1,3-diketones, providing the chiral trans beta-hydroxy ketones with two adjacent stereocenters including one alpha-tertiary or quaternary stereocenter with high enantioselectivity and diastereoselectivity. Mechanistic studies and DFT calculations suggested that the rarely observed diastereoselectivity reversal is ascribed to the charge-charge interaction between the palladium and aromatic ring of the substrate, which could not only result in the reversal of the diastereoselectivity, but also improve the reactivity.

HPLC of Formula: C8H6O2. Welcome to talk about 87-41-2, If you have any questions, you can contact Yu, CB; Wang, HD; Song, B; Shen, HQ; Fan, HJ; Zhou, YG or send Email.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

An article Discovery and Structure Relationships of Salicylanilide Derivatives as Potent, Non-acidic P2X1 Receptor Antagonists WOS:000541741100028 published article about P2X(1) ION-CHANNEL; MOUSE MODEL; ATP; ACTIVATION; EXPRESSION; RESPONSES; NF449; INHIBITOR; PHARMACOLOGY; NUCLEOTIDES in [Tian, Maoqun; Abdelrahman, Aliaa; Azazna, Djamil; Spanier, Claudia; Densborn, Sabrina; Hinz, Sonja; Mueller, Christa E.] Univ Bonn, PharmaCtr Bonn, Pharmaceut Inst, Pharmaceut & Med Chem, D-53121 Bonn, Germany; [Baqi, Younis] Sultan Qaboos Univ, Dept Chem, Fac Sci, Muscat 123, Oman; [Fuentes, Eduardo] Univ Talca, Dept Clin Biochem & Immunohaematol, Thrombosis Res Ctr, Med Technol Sch,Fac Hlth Sci,Interdisciplinary Ct, Talca 3460000, Chile; [Schmid, Ralf] Univ Leicester, Dept Mol & Cell Biol, Leicester LE1 7RH, Leics, England; [Schmid, Ralf] Univ Leicester, Leicester Inst Struct & Chem Biol, Leicester LE1 7RH, Leics, England in 2020, Cited 78. COA of Formula: C8H6O2. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2

Antagonists for the ATP-gated ion channel receptor P2X1 have potential as antithrombotics and for treating hyperactive bladder and inflammation. In this study, salicylanilide derivatives were synthesized based on a screening hit. P2X1 antagonistic potency was assessed in 1321N1 astrocytoma cells stably transfected with the human P2X1 receptor by measuring inhibition of the ATP-induced calcium influx. Structure-activity relationships were analyzed, and selectivity versus other P2X receptor subtypes was assessed. The most potent compounds, N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide (1, IC50 0.0192 mu M) and N-[3,5-bis(trifluoromethyl)phenyl]-4-chloro-2-hydroxybenzamide (14, IC50 0.0231 mu M), displayed >500-fold selectivity versus P2X2 and P2X3, and 10-fold selectivity versus P2X4 and P2X7 receptors, and inhibited collagen-induced platelet aggregation. They behaved as negative allosteric modulators, and molecular modeling studies suggested an extracellular binding site. Besides selective P2X1 antagonists, compounds with ancillary P2X4 and/or P2X7 receptor inhibition were discovered. These compounds represent the first potent, non-acidic, allosteric P2X1 receptor antagonists reported to date.

COA of Formula: C8H6O2. Welcome to talk about 87-41-2, If you have any questions, you can contact Tian, MQ; Abdelrahman, A; Baqi, Y; Fuentes, E; Azazna, D; Spanier, C; Densborn, S; Hinz, S; Schmid, R; Muller, CE or send Email.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Recently I am researching about ACID IONIC LIQUIDS; EFFICIENT SYNTHESIS; CHEMICAL-EQUILIBRIUM; METHANOL; REDUCTION; SITES; OME; PARAFORMALDEHYDE; IMPROVEMENT; TRIOXANE, Saw an article supported by the National Key R&D Program of China [2018YFB0604804]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21403268, 21703276]; Strategic Program of Coal-based Technology of Shanxi Province [MQ2014-11, MQ2014-10]; Key Research Program of the Chinese Academy of SciencesChinese Academy of Sciences [KFZD-SW-410]; CAS/SAFEA International Partnership Program for Creative Research TeamsChinese Academy of Sciences. Product Details of 87-41-2. Published in ELSEVIER SCIENCE BV in AMSTERDAM ,Authors: Wang, RY; Wu, ZW; Li, ZK; Qin, ZF; Chen, CM; Zheng, ZF; Wang, GF; Fan, WB; Wang, JG. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one

Polyoxymethylene dimethyl ethers (PODE, with the formula of CH3O-(CH2O)(n)-CH3), as a promising environmentally benign diesel fuel or additive with an enormous potential in the reduction of soot and NIC, emissions, can be efficiently synthesized from methanol derivatives such as dimethoxymethane (DMM) and trioxymethylene (TOM), which requests a proper catalyst of high performance. In this work, the catalytic performance of graphene oxide (GO) in the synthesis of PODEn as well as its relation to the catalyst structure was thoroughly investigated. The results indicate that GO is an excellent catalyst in the synthesis of PODEn from DMM and TOM; a TOM conversion of 94.6% and selectivity of 86.0% to PODE2-8 are achieved under mild reaction conditions, which is superior to the majority of the state-of-the-art catalysts. Meanwhile, the active species and characteristic layer structure of GO sheets catalytically responsible for PODEn formation were discriminated through selectively removing certain surface functional groups, thermally annealing at different temperatures, and carefully comparing with a series of model compounds. The results illustrate that the superior catalytic performance of GO in the PODEn synthesis should be ascribed to a synergy between the surface sulfonyl, hydroxyl and carboxyl groups present on the GO surface and the unique layered structure of GO sheets, wherein the surface sulfonyl groups act as the main active sites. The insights shown in this work are beneficial to a deep understanding on the catalytic principle of GO and development of efficient catalyst for the synthesis of PODEn.

Product Details of 87-41-2. Welcome to talk about 87-41-2, If you have any questions, you can contact Wang, RY; Wu, ZW; Li, ZK; Qin, ZF; Chen, CM; Zheng, ZF; Wang, GF; Fan, WB; Wang, JG or send Email.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

In 2019 CHEMOSPHERE published article about POLYCYCLIC AROMATIC-HYDROCARBONS; PHOTOLYSIS HALF-LIVES; SPIRIT OIL-SPILL; CRUDE-OIL; AQUEOUS PHOTODEGRADATION; PHOTOCATALYTIC DEGRADATION; UV-LIGHT; TOXICITY; PAHS; SEDIMENTS in [Kang, Hyun-Joong; Jung, Yerin; Kwon, Jung-Hwan] Korea Univ, Div Environm Sci & Ecol Engn, 145 Anam Ro, Seoul 02841, South Korea in 2019, Cited 65. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2. Quality Control of Isobenzofuran-1(3H)-one

Crude oil released into the environment contains many polycyclic aromatic hydrocarbons (PAHs). Alkylated PAHs are more abundant than unsubstituted PAHs and their toxicity is also of serious concern. Among the various physical, chemical, and biological weathering processes of crude oils, photodegradation is one of the most important for determining the environmental fate of oil residues. In this study, the photodegradation rate constants of naphthalene and alkylated naphthalenes were determined under simulated laboratory conditions at different temperature. Changes in the luminescence inhibition of Aliivibrio fischeri, as an indicator of the baseline toxicity, were observed in photodegradation mixtures. The major transformation products were also identified by gas chromatography-mass spectrometry. The photodegradation of naphthalene and the eight alkylated naphthalenes was described well by pseudofirst-order kinetics regardless of experimental temperature. The measured toxicity of the reaction mixtures obtained by photodegradative weathering slightly increased initially and then decreased with further weathering. In all cases, the observed toxicity was greater than accounted for by the parent compounds, indicating that the photodegradation products also contributed significantly to the overall toxicity of the mixtures. The identified photodegradation products were mostly oxygenated compounds such as alcohols, aldehydes, ketones, and quinones, which warrant further investigation. (C) 2019 Elsevier Ltd. All rights reserved.

Quality Control of Isobenzofuran-1(3H)-one. Welcome to talk about 87-41-2, If you have any questions, you can contact Kang, HJ; Jung, Y; Kwon, JH or send Email.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

An article Selective aerobic oxidation of cyclic ethers to lactones over Au/CeO2 without any additives WOS:000518591800023 published article about COPPER(II) COMPLEXES; CATALYTIC-OXIDATION; TETRAHYDROFURAN; FUNCTIONALIZATION; CLUSTERS in [Liu, Shulin; Li, Shaopeng; Shen, Xiaojun; Wang, Yanyan; Du, Juan; Chen, Bingfeng; Han, Buxing; Liu, Huizhen] Chinese Acad Sci, Beijing Natl Lab Mol Sci, CAS Key Lab Colloid & Interface, Beijing 100190, Peoples R China; [Liu, Shulin; Li, Shaopeng; Shen, Xiaojun; Wang, Yanyan; Du, Juan; Chen, Bingfeng; Han, Buxing; Liu, Huizhen] Chinese Acad Sci, Thermodynam Inst Chem, Beijing 100190, Peoples R China; [Liu, Shulin; Li, Shaopeng; Shen, Xiaojun; Wang, Yanyan; Du, Juan; Han, Buxing; Liu, Huizhen] Univ Chinese Acad Sci, Beijing 100149, Peoples R China in 2020, Cited 40. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2. Safety of Isobenzofuran-1(3H)-one

Selective oxidation of ethers to lactones with O-2 as a benign oxidant using Au/CeO2 as the catalyst has been developed. The oxygen vacancies and Au-0 species on the surface of CeO2 contribute to the activation of O-2. The excellent selectivity of lactones is due to the adsorption of ethers and activation of the C(sp(3))-H bond on Au/CeO2.

Safety of Isobenzofuran-1(3H)-one. Welcome to talk about 87-41-2, If you have any questions, you can contact Liu, SL; Li, SP; Shen, XJ; Wang, YY; Du, J; Chen, BF; Han, BX; Liu, HZ or send Email.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Authors Liu, ZK; Wang, QQ; Wang, H; Su, WT; Dong, SL in PERGAMON-ELSEVIER SCIENCE LTD published article about PARKINSONS-DISEASE; LIVING CELLS; GSH LEVELS; HOMOCYSTEINE; GLUTATHIONE; PLASMA; CHEMOSENSOR; MECHANISM; APOPTOSIS; RATHER in [Liu, Zhengkun; Wang, Qianqian; Wang, Hao; Su, Wenting; Dong, Shouliang] Lanzhou Univ, Sch Life Sci, Inst Biochem & Mol Biol, 222 Tianshui South Rd, Lanzhou 730000, Gansu, Peoples R China; [Dong, Shouliang] Lanzhou Univ, Key Lab Preclin Study New Drugs Gansu Prov, 222 Tianshui South Rd, Lanzhou 730000, Gansu, Peoples R China in 2019, Cited 47. SDS of cas: 87-41-2. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2

The specific detection of cysteine (Cys) over homocysteine (Hcy), glutathione (GSH) and other amino acids is of great significance for studying its biological functions as well as for the diagnosis of related diseases. Chloroacetyl group was often used as a reaction site for cysteine fluorescent probes for its sensitivity and selectivity. However, high background fluorescence and low stability are common problems encountered by such probes. Here, four chloroacetyl group based fluorescent probes (C1, C2, C3, and H4) was synthesized for a comparative study. We found that the inefficient quenching ability of chloroacetyl group turned into an advantage when connected with a ratiometric fluorophore. With the modification of chloroacetyl group, probe H4 displayed excellent ratiometric property and great selectivity for Cys, the stability was also improved. Additionally, the probe was successfully applied for quantitative detection of Cys in fetal bovine serum and real-time imaging in living HeLa cells with low toxicity. (C) 2019 Elsevier Ltd. All rights reserved.

SDS of cas: 87-41-2. Welcome to talk about 87-41-2, If you have any questions, you can contact Liu, ZK; Wang, QQ; Wang, H; Su, WT; Dong, SL or send Email.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

In 2020 PESTIC BIOCHEM PHYS published article about STRUCTURE-BASED DESIGN; ACARICIDAL ACTIVITY; CNIDIUM-OFFICINALE; PLANTS; BUTYLIDENEPHTHALIDE; TOXICITY; MELANIN; PROPHENOLOXIDASE; DERIVATIVES; INHIBITION in [Abbod, Mohsen; Safaie, Naser] Tarbiat Modares Univ, Fac Agr, Dept Plant Pathol, POB 14115-336, Tehran, Iran; [Gholivand, Khodayar; Bonsaii, Mahyar] Tarbiat Modares Univ, Dept Chem, POB 14115-175, Tehran, Iran; [Mehrabadi, Mohammad] Tarbiat Modares Univ, Fac Agr, Dept Entomol, POB 14115-336, Tehran, Iran in 2020, Cited 64. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2. HPLC of Formula: C8H6O2

In this study, the biological activities and mode of action of 3-butylidene phthalide (3-BPH) were studied. 3-BPH had a superior efficiency against microsclerotia of Macrophomina phaseolina compared to the commercial fungicide tricyclazole. The microsclerotia formation and pigmentation were inhibited at 100 mu g/mL. Moreover, the fungicide exhibited in silico affinity toward trihydroxy naphthalene reductase (3HNR). Both 3-BPH and tricyclazole showed congruence in the orientation and interaction within the 3HNR active site. 3-BPH displayed a strong interaction with SER-164, TYR-178, and TYR-223, with estimated binding energy and inhibition constant of -6.78 kcal mol(-1), and Ki = 12.6 mu M, respectively. Furthermore, it showed in vitro and in silico inhibitory activity against Drosophila melanogaster acetylcholinesterase in a concentration-dependent manner with IC50 = 730 mu g/mL. It also impaired Galleria mellonella phenol oxidase enzyme, which corresponds with the insect’s immune system. Phytotoxicity of 3-BPH was evident against Lemna minor at 1000 mu g/mL; nevertheless, it was nontoxic at the concentrations inhibiting M. phaseolina microsclerotia and dark pigments suggest that it may be safe for use on other plants at low doses. Further assays are wanted to develop 3-BPH as a novel crop protection compound.

HPLC of Formula: C8H6O2. Welcome to talk about 87-41-2, If you have any questions, you can contact Abbod, M; Safaie, N; Gholivand, K; Mehrabadi, M; Bonsaii, M or send Email.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Safety of Isobenzofuran-1(3H)-one. I found the field of Pharmacology & Pharmacy very interesting. Saw the article SYNTHESIS AND EVALUATION OF THE ANTIMICROBIAL AND ANTIBIOFILM ACTIVITY OF NOVEL DIBENZOTHIEPINES published in 2020, Reprint Addresses Pircalabioru, GG (corresponding author), Univ Bucharest, Res Inst, Bucharest 60101, Romania.. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one.

Considering the anti-infective potential of compounds containing the dibenzothiepine scaffold, we set out to obtain new compounds bearing this structure. The synthesized compounds were characterized by spectral studies and elemental analysis and screened for their microbiostatic/microbicidal and antibiofilm properties against reference and clinical microbial strains. The new compounds exhibited a broad spectrum of antimicrobial activity, which was more intensive for the S-oxidized compounds. Some of the compounds also inhibited the ability of the investigated strains to form biofilms on the inert substratum.

Safety of Isobenzofuran-1(3H)-one. Welcome to talk about 87-41-2, If you have any questions, you can contact Stecoza, CE; Draghici, C; Caproiu, MT; Pircalabioru, GG; Marutescu, L or send Email.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem