Archives for Chemistry Experiments of Benzo[b]furan-2-carboxaldehyde

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Neuroactive! An enantioselective, catalytic synthesis strategy provides rapid access to natural-product-inspired classes of neuritogenic compounds (see scheme). The goal is to find interesting chemical probes to shed light on neurodevelopmental processes and foster a better understanding of the complex biology and physiology of neuronal development and related neurodegenerative disorders. Copyright

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H791O – PubChem

Extracurricular laboratory:new discovery of Benzofuran-3-carbaldehyde

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Treatment of arenediazonium fluoroborates bearing suitable alkenyloxy- or alkenylamino-ortho-substituents affords ring-closed hydroxylamine derivatives via free-radical mechanism: similar treatment of o-alkynyloxy- or o-alkynylamino-arenediazonium salts gives aldehydes.

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Benzofuran – Wikipedia,
Benzofuran | C8H1168O – PubChem

Brief introduction of 66826-78-6

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The invention provides compounds of formula (I) having nematicidal, insecticidal, acaricidal and fungicidal properties, compositions comprising them and processes and intermediates for their preparation: STR1 wherein: X is oxygen or sulphur; n is 0, 1 or 2; R1, R2, R3, and R4 are as described in the specification.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H3334O – PubChem

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The synthesis of SCF3 as well as SeCF3 isosteres of two OCF3-containing drugs was achieved through visible light and copper-catalyzed processes. Herein, we show that chalcogen replacement modulates physicochemical and ADME properties without introducing intrinsic liabilities. The SCF3 and SeCF3 groups are more lipophilic than their oxygen counterpart; however, microsomal stability is unchanged, indicating that these molecular changes may be beneficial for in vivo half-life. Enabled by modern synthetic methods, we present the chalcogen-CF3 groups as potential key players for future fluorinated pharmaceuticals.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H3360O – PubChem

Properties and Exciting Facts About 125-20-2

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A pharmaceutical composition comprising a compound of formula I or II and a pharmaceutically acceptable carrier. Methods for treating a proliferative disorder mediated by a methyl transferase comprising administering an anti-proliferative effective amount of the compound of formula I or II are also presented.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H4251O – PubChem

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The comparative characterization of a series of 4-acyl-1,6-dialkylpiperazin-2-ones as potent cell entry inhibitors of the hemorrhagic fever arenavirus Lassa (LASV) is disclosed. The resolution and examination of the individual enantiomers of the prototypical LASV cell entry inhibitor 3 (16G8) is reported and the more potent (-)-enantiomer was found to be 15-fold more active than the corresponding (+)-enantiomer. The absolute configuration of (-)-3 was established by asymmetric synthesis of the active inhibitor (-)-(S)-3 (lassamycin-1). A limited deletion scan of lassamycin-1 defined key structural features required of the prototypical inhibitors.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H1105O – PubChem

The Absolute Best Science Experiment for Benzofuran-3-carbaldehyde

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A convenient approach towards enantiopure (R) and (S) isomers of 2,2,2-trifluoro-1-(heteroaryl)ethanols was developed. The enzyme-catalyzed kinetic resolution of the corresponding racemic mixtures was achieved by using a two-step protocol that involved an acylation and a hydrolysis step in the presence of Burkholderia cepacia and CAL-B lipase (Candida antarctica lipase B), respectively. Fourteen compounds were resolved on a multigram scale by using this approach. The observed enantioselectivities correlated well with the results of molecular docking experiments.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H1189O – PubChem

Extracurricular laboratory:new discovery of Benzo[b]furan-2-carboxaldehyde

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(Chemical Equation Presented) The first general methodology for the gram-scale preparation of previously overlooked beta-(hetero)aryl-alpha- nitro-alpha,beta-enals (3) is reported. Condensation of (hetero)aromatic aldehydes with 2-nitroethanol gave the E-isomers of uncommon beta-(hetero)aryl-alpha-hydroxymethyl-alpha,beta-unsatured-nitroalkenes (2), as determined by NOE and X-ray studies. alpha-Nitro-alpha,beta-enals 3 were subsequently obtained by hypervalent iodine oxidation of 2 as E-Z-mixtures in solid form. They showed varied stability and solvent-dependent thermal-promoted and photopromoted E-Z interconversion. Starting with furfural, experimental conditions were developed to prepare the corresponding nitroenal 3a enriched in either the E or the Z isomer: E-3a/Z-3a ? 90/10 and 20/80, respectively. In contrast with other structurally related compounds, nitroenals 3 have their (hetero)aryl-vinyl unit and their formyl and nitro groups all in a planar arrangement, both in solid form and in solution; accordingly, they are colored compounds with predicted high dipole moments. As deduced from solution-NMR and X-ray data, the C=C and the C=O double bonds in 3 are exclusively s-cis-oriented; this disposition corresponds in fact to the DFT-computed most stable conformer.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H945O – PubChem

Awesome and Easy Science Experiments about 569-31-3

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The annulation of phthalides with alpha-alkyl/arylacrylates in the presence of LDA/LHMDS is shown to directly give alkyl/aryl-1-naphthols. The method involving a novel dealkoxycarbonylation obviates the regiochemical issues in the synthesis of polysubstituted naphthalenes, and it forms the key step in a three-step total synthesis of arnottin I, a naphthobenzopyranone natural product.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H3139O – PubChem

Simple exploration of 3-Hydroxyisobenzofuran-1(3H)-one

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Preparation of the title compound in one operation from commercially available phthalaldehydic acid in 34percent yield is described.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H1474O – PubChem