Simple exploration of 69999-16-2

As the paragraph descriping shows that 69999-16-2 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.69999-16-2,2,3-Dihydrobenzofuranyl-5-acetic acid,as a common compound, the synthetic route is as follows.

Step 3. 2~(2,3-dihydro-l~benzofuran-5-ylmethyl)-l-(3-rnethylbutyl)-N,N-bis(2,2,2-trifluoro- ethyI)-lH-benzimidazole-5-carboxamide[0168] To a mixture of 3-amino-4-[(3-methylbutyl)amino]-N,N-bis(2,2,2- trifluoroethyl)benzamide (Step 2 of the Example 1, 0.175g, 0.454 mmol, lequiv), 2,3-dihydro-l- benzofuran-5-ylacetic acid (0.089g, 0.50 mmol, 1.1 equiv) and HATU (0.19Og, 0.500 mmol, 1.1 equpsiloniv) was added a solution of DIPEA (160 muL, 0.92 mmol, 2equiv) in DMF (5 mL). The mixture was stirred overnight at room temperature. Complete consumption of the starting material was confirmed by LC-MS. DMF was removed under reduced pressure. Ethyl acetate was added to the resulting residue. The organic layer was washed once with a saturated aqueous <n=”54″/>NaHCtheta3 solution, once with brine and dried over anhydrous Na2SO4. Ethyl acetate was removed under reduce pressure. The resulting residue was dissolved in dichloroethane and a few drops of concentrated HCl were added. The mixture was stirred at 80 C for 3 hours. Complete consumption of the starting material was confirmed by LC-MS. Dichloromethane was added. The organic layer was washed once with a 2M aqueous NaOH solution, once with brine and dried over anhydrous Na2SO4. Dichloromethane was removed under reduced pressure. The resulting residue was purified by column chromatography on silica gel (hexanes/EtOAc, 50:50) to afford 2-(2,3-dmydro-l-benzofuran-5-ylmethyl)-l-(3-methylbutyl)-N,N-bis(2,2,2-trifluoro- ethyl)-lH-benzimidazole-5-carbochiamide (0.173 mg) in 72% yield. The product was dissolved in methanol (about 5 mL) and 1 equivalent of TFA was added. The mixture was stirred at room temperature for about 30 minutes. Methanol was removed under reduced pressure. Water was added and the resulting residue was lyophilized to afford 2-(2,3-dihydro-l-benzofuran-5- ymiethyl)-l-(3-me1hylbu1yl)-N,N-bis(2,2,2-trifluoro-e&yl)-lH-benzimidazole-5-carboxamide as the corresponding TFA salt. 1H NMR (400 MHz, METHANOL-D4) 6 ppm 0.96 (d, /=6.64 Hz, 6 H) 1.45 – 1.54 (m, 2 H) 1.63 – 1.75 (m, 1 H) 3.18 (t, /=8.79 Hz, 2 H) 4.32 – 4.44 (m, 6 H) 4.49 (s, 2 H) 4.54 (t, J=8.79 Hz, 2 H) 6.75 (d; /=8.20 Hz, 1 H) 7.07 (dd, J=8.20, 1.95 Hz, 1 H) 7.20 (s, 1 H) 7.58 (dd, /=8.50, 1.46 Hz, 1 H) 7.79 (d, /=0.78 Hz, 1 H) 7.87 (d, /=8.59 Hz, 1 H); MS (ESI) m/z 527.8 (MHhH)+; Anal. Calcd (%) for C26H27F6N3O2 + 1.0 TFA: C, 52.42; H, 4.40; N, 6.55. Found: C, 52.52; H, 4.27; N 6.18.

As the paragraph descriping shows that 69999-16-2 is playing an increasingly important role.

Reference£º
Patent; ASTRAZENECA AB; WO2007/91950; (2007); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

Downstream synthetic route of 18761-31-4

The synthetic route of 18761-31-4 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.18761-31-4,5-Nitrobenzofuran,as a common compound, the synthetic route is as follows.

EXAMPLE 33 N-(4-methylfuro[2,3-g]quinazolin-2-yl)guanidine was made in the same manner as N-(6,7-dibutoxy-4-methyl-2-quinazolinyl)guanidine (see Example 1) except that 5-nitro-[2,3]-benzofuran was used in place of 1,2-dibutoxy-4-nitrobenzene. Name: 6,6,8-trimethyl-5,6-dihydrofuro[2,3-g]quinoline (synthesised using Method B (70% yield)). Data: 1H NMR (CDCl3) delta 7.53 (br s, 1H), 7.21 (dd, 1H, J=8.4, 0.6 Hz), 6.94 (br s, 1H), 6.51 (d, 1H, J=8.4 Hz), 5.38 (d, 1H, J=1.2 Hz), 2.29 (d, 3H, J=1.2 Hz), 1.29 (s, 6H).

The synthetic route of 18761-31-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Forray, Carlos C.; Kawakami, Joel; Konkel, Michael J.; Boteju, Lakmal W.; Wetzel, John M.; Noble, Stewart A.; Wan, Honghe; US2003/176314; (2003); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

 

Analyzing the synthesis route of 95333-17-8

#N/A

95333-17-8, Benzofuran-4-carbonitrile is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In a single-necked flask, add benzofuran-4-carbonitrile C1-1e (300 mg, 2.09 mmol), methanol (50 mL), nickel chloride (543 mg, 4.19 mmol), and slowly add sodium borohydride (159 mg, 4.19 mmol). , 2 hours reaction at room temperature.The mixture was filtered through celite, washed with methanol,The filtrate was concentrated under reduced pressure to obtain a crude product. The crude was purified on silica gel (dichloromethane:Methanol = 10: 1) to give benzofuran-4-ylmethylamine C2-1 (50 mg, 16.2% yield) as a yellow solid.

#N/A

Reference£º
Patent; Shanghai Qingyu Pharmaceutical Technology Co., Ltd.; Zou Bin; Ma Shichao; Wang Xiang; Zhang Zhongguo; (92 pag.)CN110563722; (2019); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

 

Some tips on 17403-47-3

The synthetic route of 17403-47-3 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17403-47-3,5-Nitro-2,3-dihydrobenzofuran,as a common compound, the synthetic route is as follows.

General procedure: Procedure B: The nitro-group containing compound was dissolved in MeOH (or a mixture of MeOH and tetrahydrofuran) and then 10% Pd/C was added. The mixture was stirred at room temperature under hydrogen gas until the starting material had been consumed. The crude mixture was filtered through Celite, washed with methanol, and then concentrated. The product was carried on to the next step without further purification or was purified by column chromatography.

The synthetic route of 17403-47-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Lee, Jeewoo; Tran, Phuong-Thao; Hoang, Van-Hai; Thorat, Shivaji A.; Kim, Sung Eun; Ann, Jihyae; Chang, Yu Jin; Nam, Dong Woo; Song, Hyundong; Mook-Jung, Inhee; Lee, Jiyoun; Bioorganic and Medicinal Chemistry; vol. 21; 13; (2013); p. 3821 – 3830;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

 

Some tips on 23681-89-2

23681-89-2 2,3-Dihydrobenzofuran-6-ol 12236540, abenzofuran compound, is more and more widely used in various.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.23681-89-2,2,3-Dihydrobenzofuran-6-ol,as a common compound, the synthetic route is as follows.

EXAMPLE 25 875 mg. of a 55percent by weight sodium hydride dispersion in oil are washed three times with absolute tetrahydrofuran and then covered with 10 ml. of absolute tetrahydrofuran. Thereafter, the mixture is treated at 0¡ã C. and while stirring with a solution of 2.72 g. of 6-hydroxy-2,3-dihydrobenzofuran in 12 ml. of absolute tetrahydrofuran. The mixture is stirred for one hour (during which time it is allowed to warm up to room temperature), then again cooled to 0¡ã C. and added dropwise to a solution of 1-bromo-7-ethoxy-3,7-dimethyl-2-octene in 12 ml. of absolute tetrahydrofuran. 12 ml. of pure hexamethylphosphoric acid triamide are then added to the mixture, the ice bath is removed and the mixture stirred for 3 hours. The mixture is worked up by pouring it onto ice-water and extracting the resulting mixture three times with diethyl ether. The extracts are washed with water and saturated aqueous sodium chloride solution, dried over sodium sulfate and evaporated. By chromatography on silica gel with hexane/diethyl ether (19:1 parts by volume) there is obtained pure 6-[(7-ethoxy-3,7-dimethyl-2-octenyl)-oxy]-2,3-dihydrobenzofuran which is distilled in a bulb-tube at 150¡ã C./0.05 mmHg; nD20.5 = 1.5172.

23681-89-2 2,3-Dihydrobenzofuran-6-ol 12236540, abenzofuran compound, is more and more widely used in various.

Reference£º
Patent; Hoffmann-La Roche Inc.; US4002647; (1977); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

 

Analyzing the synthesis route of 59434-19-4

As the paragraph descriping shows that 59434-19-4 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.59434-19-4,4-Aminophthalide,as a common compound, the synthetic route is as follows.

Example 139A(?)-6-Fluoro-4-((l -methyl- lH-imidazol-2-yl)methyleneamino)isobenzofuran- 1 (3H)-one[00798] A solution of 1 -methyl- lH-imidazole-2-carbaldehyde (659 mg, 6.0 mmol), 4-amino-6- fluoroisobenzofuran- 1 (3H)-one (1.0 g, 6.0 mmol), and anhydrous magnesium sulfate (7.2 g, 60.0 mmol) in acetonitrile (100 mL) was heated to reflux for 2 days. The solution was filtered and the solvents were removed in vacuum. The crude product was re-crystallized from isopropanol to afford the title compound (1.068 g, yield 68%) LC-MS (ESI) m/z: 260 (M+l)+. ?-NMR (400 MHz, DMSO-d6) delta (ppm): 4.04 (s, 3H), 5.49 (s, 2H), 7.24 (s, 1H), 7.54-7.58 (m, 2H), 7.73-7.76 (m, 1H), 8.70 (s, 1H).

As the paragraph descriping shows that 59434-19-4 is playing an increasingly important role.

Reference£º
Patent; BIOMARIN PHARMACEUTICAL INC.; WANG, Bing; CHU, Daniel; WO2011/130661; (2011); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

 

Brief introduction of 69999-16-2

69999-16-2 2,3-Dihydrobenzofuranyl-5-acetic acid 2737455, abenzofuran compound, is more and more widely used in various.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.69999-16-2,2,3-Dihydrobenzofuranyl-5-acetic acid,as a common compound, the synthetic route is as follows.

2-(2,3-Dihydro-benzofuran-5-yl)-ethanol Borane-THF complex (1 M) (52ml_, 52mmol) was slowly added to a solution of 2,3- dihydro-5-benzofuranacetic acid (4.62g, 25.9mmol) in 15OmL dry THF cooled to O0C under a nitrogen atmosphere. The reaction mixture was allowed to warm up to RT and stirred for 2Oh. Water (5OmL) was added, and the mixture stirred for 20 min. Ethyl acetate was added and the phases were separated. The aqueous layer was further extracted with ethyl acetate, the combined organic layers were dried (MgSO4) and concentrated to give the title product as light brown viscous oil. Yield: 4.2g (100%) LC-MS (Method 2): Rt 2.37 mins, molecular ion not observed.

69999-16-2 2,3-Dihydrobenzofuranyl-5-acetic acid 2737455, abenzofuran compound, is more and more widely used in various.

Reference£º
Patent; ARGENTA DISCOVERY LTD.; WO2008/96093; (2008); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

 

Analyzing the synthesis route of 6940-49-4

6940-49-4 3-Bromophthalide 96218, abenzofuran compound, is more and more widely used in various.

6940-49-4, 3-Bromophthalide is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Amine (1.05 Equiv) was added to Isatoic anhydride (1.0 Equiv) in water (4.0mL) and PEG400 (1.0mL) at RT and stirred for 1-2 hr. Upon completion of SM by TLC, added 3-bromoisobenzofuran-1(3H)-one (1.1 Equiv) and warm the reaction mixture to 90-95 C and maintained for 10-14 h. After completion of the reaction, cool the reaction mass up to 25-30 C and product was filtered and further purified via column chromatography through silica gel stationary phase and Ethyl acetate & Heptane mixture as eluent.

6940-49-4 3-Bromophthalide 96218, abenzofuran compound, is more and more widely used in various.

Reference£º
Article; Madhubabu; Shankar; Reddy, G. Rajeshwar; Rao, T. Srinivasa; Basaveswara Rao, Mandava V.; Akula, Raghunadh; Tetrahedron Letters; vol. 57; 46; (2016); p. 5033 – 5037;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

 

Downstream synthetic route of 90843-31-5

The synthetic route of 90843-31-5 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.90843-31-5,5-Acetyl-2,3-dihydrobenzo[b]furan,as a common compound, the synthetic route is as follows.

General procedure: The target thiosemicarbazones were prepared by dissolving corresponding ketone (2a-b) (0.005 mol) and appropriate thiosemicarbazide (1a-q) (0.005 mol) in ethanol containing 1-2 drops of HCl as catalyst. The reaction mixture was heated under reflux at 80 C for 2-3 h and course of the reaction was monitored by TLC. After the reaction completion,the excess solvent was evaporated under vacuum and the crystalline or amorphous product formed was filtered, washed with hot ethanol and then with diethyl ether to afford the required thiosemicarbazones (3a-u) in excellent yields. The synthesized thiosemicarbazones were further recrystallized by mixture of chloroform-ethanol (1:1). For X-ray measurements, single crystal of 3m was mounted on a MiTeGen loop with grease and examined on a Bruker D8 Venture APEX diffractometer equipped with Photon 100 CCD area detector and Oxford Cryostream cooler at 296 (2) K using graphite-monochromated Mo-Kalpharadiation (lambda=0.71073 A). Data was collected using the APEX-II software [33], integrated using SAINT [34] and corrected for absorption using a multi-scan approach (SADABS) [35]. The structure was solved using intrinsic phasing (SHELXT) [36]. Final cell constants were determined from full least squares refinement of all observed reflections. All non-H atoms were located in subsequent difference maps and refined anisotropically with SHELXL-97 [37], using full least squares refinement against F2. H-atoms were added at calculated positions and refined with a riding model. The structure has been deposited with the CCDC (CSD deposition numbers 1874544).

The synthetic route of 90843-31-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Islam, Muhammad; Khan, Ajmal; Shehzad, Muhammad Tariq; Hameed, Abdul; Ahmed, Nadeem; Halim, Sobia Ahsan; Khiat, Mohammed; Anwar, Muhammad Usman; Hussain, Javid; Csuk, Rene; Shafiq, Zahid; Al-Harrasi, Ahmed; Bioorganic Chemistry; vol. 87; (2019); p. 155 – 162;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

 

New learning discoveries about 35700-40-4

35700-40-4 2,3-Dihydrobenzofuran-7-carboxylic acid 2795014, abenzofuran compound, is more and more widely used in various.

35700-40-4, 2,3-Dihydrobenzofuran-7-carboxylic acid is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A suspension of 2,3-dihydro-benzofiran-7-carboxylic acid, (TCI, 20.0 g, 121.8 mmol) in 600 mL of dry acetonitrile was cooled to 0 0C and treated with N,O-dirnethylhydroxylamine hydrochloride (14.25 g, 146.1 mmol). The reaction was allowed to stirfor 10 minutes and EDCI (24.6 g, 158.3 mmol) was added, followed by HOBT (3.2 g, 24.2 mmol) and the resulting mixture was allowed to stirfor 5 minutes. Triethylamine (365.4 mmol) was then added and the reaction mixture was allowed to stirfor 18 hours at room temperature, then diluted with aqueous IN HCl (250 mL) and extracted with ethyl acetate (1.0 L). The organic layer was sequentially washed with aqueous 10% potassium carbonate (200 mL), aqueous IN HCl (200 mL), and brine (200 mL). The organic layer was then dried over magnesium sulfate, filtered and concentrated in vacuo to provide compound 2A (23.37 g, 93 %) as a colorless oil. M.S. found for CnHnNO3: 230.1 1 (M^Na)+.

35700-40-4 2,3-Dihydrobenzofuran-7-carboxylic acid 2795014, abenzofuran compound, is more and more widely used in various.

Reference£º
Patent; SCHERING CORPORATION; WO2009/152200; (2009); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem