Heterocyclic Building Block-benzofuran

Kapche, Gilbert D. W. F. published the artcilePrenylated arylbenzofuran derivatives from Morus mesozygia with antioxidant activity, HPLC of Formula: 56317-21-6, the publication is Phytochemistry (Elsevier) (2009), 70(2), 216-221, database is CAplus and MEDLINE.

Five prenylated arylbenzofurans, moracins Q-U, were isolated from Morus mesozygia (Moraceae). Their structures were elucidated on the basis of spectroscopic evidence. Along with these compounds, 3β-acetoxyurs-12-en-11-one, marsformoxide, moracin C, moracin M, moracin K, artocarpesin, cycloartocarpesin, morachalcone A were also isolated. Four of the five compounds (moracins R-U) displayed potent antioxidant activity.

Phytochemistry (Elsevier) published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C14H10O4, HPLC of Formula: 56317-21-6.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Steinhuebel, Dietrich P. published the artcileStereoselective Organo-Zinc Addition Reactions to 1,2-Dihydropyrans for the Assembly of Complex Pyran Structures, SDS of cas: 69626-75-1, the publication is Organic Letters (2002), 4(2), 293-295, database is CAplus and MEDLINE.

Nucleophilic addition of organo-zinc to 1,2-dihydropyranyl acetates represents a new, broadly defined method for the stereocontrolled synthesis of α-substituted pyrans. The products obtained from this process are versatile materials that can be used to construct C-glycosides and other functionalized pyran structures of import. The occurrence of pyranyl groups in both natural products and therapeutically active agents confers added value to the studies described herein.

Organic Letters published new progress about 69626-75-1. 69626-75-1 belongs to benzofurans, auxiliary class Iodide,Benzofuran, name is 2-Iodobenzofuran, and the molecular formula is C18H23N3O4S, SDS of cas: 69626-75-1.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Escobedo, P. published the artcileSmart facemask for wireless CO₂ monitoring, Name: 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one, the publication is Nature Communications (2022), 13(1), 72, database is CAplus and MEDLINE.

The use of facemasks by the general population is recommended worldwide to prevent the spread of SARS-CoV-2. Despite the evidence in favor of facemasks to reduce community transmission, there is also agreement on the potential adverse effects of their prolonged usage, mainly caused by CO2 rebreathing. Herein we report the development of a sensing platform for gaseous CO2 real-time determination inside FFP2 facemasks. The system consists of an opto-chem. sensor combined with a flexible, battery-less, near-field-enabled tag with resolution and limit of detection of 103 and 140 ppm resp., and sensor lifetime of 8 h, which is comparable with recommended FFP2 facemask usage times. We include a custom smartphone application for wireless powering, data processing, alert management, results displaying and sharing. Through performance tests during daily activity and exercise monitoring, we demonstrate its utility for non-invasive, wearable health assessment and its potential applicability for preclin. research and diagnostics.

Nature Communications published new progress about 596-01-0. 596-01-0 belongs to benzofurans, auxiliary class Benzofuran,Naphthalene,Alcohol,Ester, name is 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one, and the molecular formula is C28H18O4, Name: 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Perez de Vargas-Sansalvador, I. M. published the artcileA new light emitting diode-light emitting diode portable carbon dioxide gas sensor based on an interchangeable membrane system for industrial applications, Recommanded Product: 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one, the publication is Analytica Chimica Acta (2011), 699(2), 216-222, database is CAplus and MEDLINE.

A CO₂ measurement system (0-100%) based on a paired emitter-detector diode arrangement as a colorimetric detector is described. Two different configurations were tested. Configuration 1 (opposite side configuration), where a secondary inner filter effect accounted for CO₂ sensitivity, involved absorption of phosphorescence emitted from a CO₂-insensitive luminophore by an acid-base indicator. Configuration 2, where the luminophore-containing membrane was removed, simplified the sensing membrane which now only contained the acid-base indicator. Also, 2 different instrumental configurations were assessed, using a paired emitter/detector diode system consisting of 2 light-emitting diodes (LED) where one diode was used as the light source (emitter) and the other diode was used in reverse bias mode as the light detector. The first configuration used a green LED as emitter and a red LED as detector; the second configuration used 2 identical red LED as emitter and detector. The system was characterized for sensitivity, dynamic response, reproducibility, stability, and temperature influence. Results showed configuration 2 had a better CO₂ response in terms of sensitivity.

Analytica Chimica Acta published new progress about 596-01-0. 596-01-0 belongs to benzofurans, auxiliary class Benzofuran,Naphthalene,Alcohol,Ester, name is 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one, and the molecular formula is C28H18O4, Recommanded Product: 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Perez de Vargas-Sansalvador, Isabel M. published the artcileWater based-ionic liquid carbon dioxide sensor for applications in the food industry, Synthetic Route of 596-01-0, the publication is Sensors and Actuators, B: Chemical (2017), 302-309, database is CAplus.

A new water-based sensor for carbon dioxide containing an ionic liquid is presented. The sensor is based on the acidity of the CO₂ mol. The sensor incorporates an ionic liquid in the matrix, which enhances CO₂ solubility, and minimising the response and recovery times of the sensor. The entire concentration range (0-100%) of CO₂ in water has been studied. The sensor is more sensitive at low CO₂ concentrations as is usual in this kind of optical sensor. As the sensor is intended for smart food packaging, one of the most important characteristics is stability, and this has been studied under different conditions of light, temperature and relative humidity. The sensor was found to be stablef or more than 14 days, which is the period of use for the intended application. Pork chops were packed at 4 °C and the production of CO₂ studied in conjunction with total bacterial counts over a period of 14 days. The results show that the concentration of CO₂ dioxide increases in time, in correlation with bacterial counts. As the threshold of CO₂ content for human consumption of this meat is 20%, the sensor has been optimized for detection around this concentration

Sensors and Actuators, B: Chemical published new progress about 596-01-0. 596-01-0 belongs to benzofurans, auxiliary class Benzofuran,Naphthalene,Alcohol,Ester, name is 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one, and the molecular formula is C28H18O4, Synthetic Route of 596-01-0.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Escobedo, P. published the artcileFlexible Passive near Field Communication Tag for Multigas Sensing, Product Details of C28H18O4, the publication is Analytical Chemistry (Washington, DC, United States) (2017), 89(3), 1697-1703, database is CAplus and MEDLINE.

In this work we present a full-passive flexible multigas sensing tag for the determination of oxygen, carbon dioxide, ammonia, and relative humidity readable by a smart-phone. This tag is based on near field communication (NFC) technol. for energy harvesting and data transmission to a smart-phone. The gas sensors show an optic response that is read through high-resolution digital color detectors. A white LED is used as the common optical excitation source for all the sensors. Only a reduced electronics with very low power consumption is required for the reading of the optical responses and data transmission to a remote user. An application for the Android operating system has been developed for the power supplying and data reception from the tag. The responses of the sensors have been calibrated and fitted to simple functions, allowing a fast prediction of the gases concentration Cross-sensitivity has also been evaluated, finding that in most of the cases it is negligible or easily correctable using the rest of the readings. The election of the target gases has been due to their importance in the monitoring of modified atm. packaging. The resolutions and limits of detection measured are suitable for such kinds of applications.

Analytical Chemistry (Washington, DC, United States) published new progress about 596-01-0. 596-01-0 belongs to benzofurans, auxiliary class Benzofuran,Naphthalene,Alcohol,Ester, name is 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one, and the molecular formula is C28H18O4, Product Details of C28H18O4.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Thomas Pannakal, Steve published the artcileComprehensive characterization of naturally occurring antioxidants from the twigs of mulberry (Morus alba) using on-line high-performance liquid chromatography coupled with chemical detection and high-resolution mass spectrometry, Recommanded Product: 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, the publication is Phytochemical Analysis (2022), 33(1), 105-114, database is CAplus and MEDLINE.

The mulberry tree (Morus alba L.) is a prolific source of biol. active compounds There is considerable growing interest in probing M. alba twigs as a source of disruptive antioxidant lead candidates for cosmetic skin care product development. An integrated approach using high-performance liquid chromatog. (HPLC) coupled with either chem. detection (CD) or high-resolution mass spectrometry (HRMS) was applied to the hydroalcoholic extract of M. alba to detect and identify lead antioxidant compounds, resp. The twigs were weighed, powd. and homogenized using a mill and the extract was prepared using 70% aqueous ethanol. The antioxidant metabolites were detected with HPLC coupled with CD (based on the ORAC assay) and their structural identification was carried out using a Q-Exactive Orbitrap MS instrument. Using this approach, 13 peaks were detected as overall contributors to the antioxidant activity of M. alba , i.e. mulberrosides (A & E), oxyresveratrol & its derivatives, moracin & its derivatives and a dihydroxy-octadecadienoic acid, which together accounted for >90% of the antioxidant activity, highlighting the effectiveness of the integrated approach based on HPLC-CD and HPLC-HRMS. Addnl., a 3,4-dimethoxyphenyl-1-O-β-D-apiofuranosyl-(1 → 6)-O-β-D-glucopyranoside was also discovered for the first time from the twig extract and is presented here. To our knowledge, this is the first report from M. alba twigs using HPLC-CD and HPLC-HRMS that identifies key compounds responsible for the antioxidant property of this native Chinese medicinal plant.

Phytochemical Analysis published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C10H2F12NiO4, Recommanded Product: 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Kumar, Nag S. published the artcileDiscovery and optimization of a new class of pyruvate kinase inhibitors as potential therapeutics for the treatment of methicillin-resistant Staphylococcus aureus infections, SDS of cas: 69626-75-1, the publication is Bioorganic & Medicinal Chemistry (2014), 22(5), 1708-1725, database is CAplus and MEDLINE.

A novel series of bis-indoles derived from naturally occurring marine alkaloid cis-3,4-dihydrohamacanthin B (I) was synthesized and evaluated as inhibitors of methicillin-resistant Staphylococcus aureus (MRSA) pyruvate kinase (PK). PK is not only critical for bacterial survival which would make it a target for development of novel antibiotics, but it is reported to be one of the most highly connected ‘hub proteins’ in MRSA, and thus should be very sensitive to mutations and making it difficult for the bacteria to develop resistance. From the co-crystal structure of I bound to S. aureus PK we were able to identify the pharmacophore needed for activity. Consequently, we prepared simple direct linked bis-indoles such as 6,6′-dibromo-2,2′-biindolyl [II; R, R’ = 6,6′-dibromo (b)] that have similar anti-MRSA activity as compound I. Structure-activity relationship (SAR) studies on II led us to discover more potent compounds such as II [R, R’ = 6,5′-dibromo; 6-bromo-5′-chloro; 5,6,6′-tribromo; 5,6,5′-tribromo (c, d, k, m, resp.)] with enzyme inhibiting activities in the low nanomolar range that effectively inhibited the bacteria growth in culture with min. inhibitory concentrations (MIC) for MRSA as low as 0.5 μg/mL. Some potent PK inhibitors, such as IIb, exhibited attenuated antibacterial activity and were found to be substrates for an efflux mechanism in S. aureus. Studies comparing a wild type S. aureus with a construct (S. aureus LAC Δpyk::Erm^R) that lacks PK activity confirmed that bactericidal activity of IId was PK-dependant.

Bioorganic & Medicinal Chemistry published new progress about 69626-75-1. 69626-75-1 belongs to benzofurans, auxiliary class Iodide,Benzofuran, name is 2-Iodobenzofuran, and the molecular formula is C8H5IO, SDS of cas: 69626-75-1.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Lang, Li published the artcile2-Arylbenzo[b]furan derivatives as potent human lipoxygenase inhibitors, Recommanded Product: 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, the publication is Journal of Enzyme Inhibition and Medicinal Chemistry (2016), 31(sup4), 98-105, database is CAplus and MEDLINE.

Human lipoxygenases (LOXs) have been emerging as effective therapeutic targets for inflammatory diseases. In this study, we found that four natural 2-arylbenzo[b]furan derivatives isolated from Artocarpus heterophyllus exhibited potent inhibitory activities against human LOXs, including moracin C, artoindonesianin B-1, moracin D, moracin M. In our in vitro experiments, compound 1 was identified as the most potent LOX inhibitor and the moderate subtype selective inhibitor of 12-LOX. Compounds 1 and 2 act as competitive inhibitors of LOXs. Moreover, 1 significantly inhibits LTB4 production and chemotactic capacity of neutrophils, and is capable of protecting vascular barrier from plasma leakage in vivo. In addition, the preliminary structure-activity relationship anal. was performed based on the above four naturally occurring (1-4) and six addnl. synthetic 2-arylbenzo[b]furan derivatives Taken together, these 2-arylbenzo[b]furan derivatives, as LOXs inhibitors, could represent valuable leads for the future development of therapeutic agents for inflammatory diseases.

Journal of Enzyme Inhibition and Medicinal Chemistry published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C14H10O4, Recommanded Product: 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Wang, Xiao-Ling published the artcileNew phenolic compounds from the leaves of Artocarpus heterophyllus, HPLC of Formula: 56317-21-6, the publication is Chinese Chemical Letters (2017), 28(1), 37-40, database is CAplus.

One new 2-arylbenzofuran derivative, artocarstilbene B (I), one new benzaldehyde derivative, (E)-3,5-dihydroxy-4-(3-methylbut-1-enyl)benzaldehyde (II), as well as 18 known compounds (3-20) were obtained from the leaves of Artocarpus heterophyllus. Their structures were elucidated on the basis of extensive spectroscopic techniques including 2D NMR and HR-ESIMS. Many compounds exhibited moderate to weak inhibitory activity against the proliferation of the PC-3, NCI-H460, and A549 cancer cell lines.

Chinese Chemical Letters published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C22H21N3O3S, HPLC of Formula: 56317-21-6.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem