Heterocyclic Building Block-benzofuran

Chakrabarty, Suman published the artcileFacile access to functionalized chiral secondary benzylic boronic esters via catalytic asymmetric hydroboration, COA of Formula: C8H5IO, the publication is Chemical Science (2019), 10(18), 4854-4861, database is CAplus and MEDLINE.

Allylic and homoallylic phosphonates bearing an aryl or heteroaryl substituent at the γ- or δ-position undergo rhodium-catalyzed asym. hydroboration by pinacolborane to give functionalized chiral secondary benzylic boronic esters in yields up to 86% and enantiomer ratios up to 99 : 1. Compared to minimally-functionalized terminal and 1,1-disubstituted vinyl arenes, there are relatively few reports of efficient catalytic asym. hydroboration (CAHB) of more highly functionalized internal alkenes. Phosphonate substrates bearing a variety of common heterocyclic ring systems, including furan, indole, pyrrole and thiophene derivatives, as well as those bearing basic nitrogen substituents (e.g., morpholine and pyrazine) are tolerated, although donor substituents positioned in close proximity of the alkene can influence the course of the reaction. Stereoisomeric (E)- and (Z)-substrates afford the same major enantiomer of the borated product. Deuterium-labeling studies reveal that rapid (Z)- to (E)-alkene isomerization accounts for the observed (E/Z)-stereoconvergence during CAHB. The synthetic utility of the chiral boronic ester products is illustrated by stereospecific C-B bond transformations including stereoretentive electrophile promoted 1,2-B-to-C migrations, stereoinvertive S_E2 reactions of boron-ate complexes with electrophiles, and stereoretentive palladium- and rhodium-catalyzed cross-coupling protocols.

Chemical Science published new progress about 69626-75-1. 69626-75-1 belongs to benzofurans, auxiliary class Iodide,Benzofuran, name is 2-Iodobenzofuran, and the molecular formula is C8H5IO, COA of Formula: C8H5IO.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Matsuki, Yuki published the artcileAryl radical-mediated N-heterocyclic carbene catalysis, Related Products of benzofurans, the publication is Nature Communications (2021), 12(1), 3848, database is CAplus and MEDLINE.

There have been significant advancements in radical reactions using organocatalysts in modern organic synthesis. Recently, NHC-catalyzed radical reactions initiated by single electron transfer processes have been actively studied. However, the reported examples have been limited to catalysis mediated by alkyl radicals. In this article, the NHC organocatalysis mediated by aryl radicals has been achieved. The enolate form of the Breslow intermediate derived from an aldehyde and thiazolium-type NHC in the presence of a base undergoes single electron transfer to an aryl iodide, providing an aryl radical. The catalytically generated aryl radical could be exploited as an arylating reagent for radical relay-type arylacylation of styrenes and as a hydrogen atom abstraction reagent for α-amino C(sp³)-H acylation of secondary amides.

Nature Communications published new progress about 69626-75-1. 69626-75-1 belongs to benzofurans, auxiliary class Iodide,Benzofuran, name is 2-Iodobenzofuran, and the molecular formula is C8H5IO, Related Products of benzofurans.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Korenman, Ya. I. published the artcileTitrimetric determination of aromatic acids in nonaqueous concentrates, Application In Synthesis of 596-01-0, the publication is Journal of Analytical Chemistry (Translation of Zhurnal Analiticheskoi Khimii) (1998), 53(12), 1125-1130, database is CAplus.

The extraction of aromatic acids by hydrophilic solvents from aqueous solutions in the absence and the presence of salts was studied. Efficient extraction systems are proposed as media for nonaqueous titrations Procedures for the sep. titrimetric, potentiometric, conductometric, and photometric determination of aromatic acids in nonaqueous concentrates were developed.

Journal of Analytical Chemistry (Translation of Zhurnal Analiticheskoi Khimii) published new progress about 596-01-0. 596-01-0 belongs to benzofurans, auxiliary class Benzofuran,Naphthalene,Alcohol,Ester, name is 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one, and the molecular formula is C28H18O4, Application In Synthesis of 596-01-0.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Hedvall, J. A. published the artcilePhotoadsorption effects in the system pigment-fluid phase, Recommanded Product: 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one, the publication is Arkiv foer Kemi, Mineralogi och Geologi (1943), 17A(No. 11), 11 pp., database is CAplus.

The adsorption by red and black HgS of phenolphthalein from aqueous EtOH solution and by CdS of α-naphtholphthalein from similar solutions has been investigated under varying light conditions. Light has little effect on adsorption by black HgS but red HgS adsorbs six times as much phthalein in light as in darkness. This difference is ascribed to the different electronic structures of red and black HgS. Black HgS and irradiated red HgS are conductors, whereas in darkness red HgS is an insulator. CdS adsorbs phthalein much more when irradiated than in darkness. In each case adsorption in darkness is increased by presence of excess of S in the sulfide, A parallel is drawn between these photoadsorption effects and the Becquerel or photovoltaic effect.

Arkiv foer Kemi, Mineralogi och Geologi published new progress about 596-01-0. 596-01-0 belongs to benzofurans, auxiliary class Benzofuran,Naphthalene,Alcohol,Ester, name is 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one, and the molecular formula is C28H18O4, Recommanded Product: 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Tran, Huynh Nguyen Khanh published the artcileAnti-inflammatory activities of compounds from twigs of Morus alba, Recommanded Product: 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, the publication is Fitoterapia (2017), 17-24, database is CAplus and MEDLINE.

Five new compounds, 10-oxomornigrol F (1), (7′′R)-(-)-6-(7′′-hydroxy-3′′,8′′-dimethyl-2′′,8′′-octadien-1′′-yl)apigenin (2), ramumorin A (3), ramumorin B (4), and (4S,7S,8R)-trihydroxyoctadeca-5Z-enoic acid (5), together with 31 known compounds (6-36), were isolated from the twigs of Morus alba (Moraceae). The chem. structures of these compounds were established using spectroscopic analyses, 1D and 2D NMR, high-resolution electrospray ionization mass spectrometry (HRESIMS), and Mosher′s methods. The anti-inflammatory activities of the compounds were evaluated by investigating their ability to inhibit lipopolysaccharide (LPS)-induced nitric oxide (NO) production in macrophage RAW 264.7 cells. Compounds 1, 2, 13, 17, 19, 25-28, and 32 showed inhibitory effects with IC₅₀ values ranging from 2.2 to 5.3 μg/mL. Compounds 1, 2, 17, 25, and 32 reduced LPS-induced inducible nitric oxide synthase (iNOS) expression in a concentration-dependent manner. In addition, pretreating the cells with compound 1, 17, and 32 significantly suppressed LPS-induced expression of cyclooxygenase-2 (COX-2) protein.

Fitoterapia published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C5H9IO2, Recommanded Product: 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Garcia-Dominguez, Patricia published the artcileAu-Pd Bimetallic Catalysis: The Importance of Anionic Ligands in Catalyst Speciation, Product Details of C8H5IO, the publication is Journal of the American Chemical Society (2016), 138(10), 3266-3269, database is CAplus and MEDLINE.

Synergistic gold-palladium catalytic processes have been intensively sought during the past decade, because the combination of the carbophilic Lewis acidity of Au with the redox properties of Pd within a catalytic cycle particularly appealing for the synthesis of novel functionalized compounds We demonstrate here the feasibility of a Au-Pd bimetallic catalytic system based on the generation of competent Au and Pd species by anionic ligand exchange. This strategy enabled the preparation of a variety of substituted butenolides in a simple and efficient way.

Journal of the American Chemical Society published new progress about 69626-75-1. 69626-75-1 belongs to benzofurans, auxiliary class Iodide,Benzofuran, name is 2-Iodobenzofuran, and the molecular formula is C8H5IO, Product Details of C8H5IO.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Mokhtari Brikci-Nigassa, Nahida published the artcileFunctionalization of 9-thioxanthone at the 1-position: From arylamino derivatives to [1]benzo(thio)pyrano[4,3,2-de]benzothieno[2,3-b]quinolines of biological interest, HPLC of Formula: 69626-75-1, the publication is Bioorganic Chemistry (2020), 103347, database is CAplus and MEDLINE.

Original 1-amino substituted thioxanthone derivatives were easily prepared from the bare heterocycle by a deprotometalation-iodolysis-copper-catalyzed C-N bond formation sequence. This last reaction delivered mono- or/and diarylated products I (R = 4-FC₆H₄, 1-naphthyl, 3-aminopyridin-2-yl, etc.) and II (R = 4-CH₃C₆H₄, 4-CH₃OC₆H₄) depending on the anilines RNH₂ involved. 1-Amino-9-thioxanthone was also prepared and reacted with 2-iodoheterocycles R¹I (R¹ = 2-thienyl, 1-benzothiophen-2-yl, 1-benzofuran-2-yl). Interestingly, while 1-(arylamino)-9-thioxanthones like 1-(2-thienylamino)-9-thioxanthone and 1-(2-benzothienylamino)-9-thioxanthone could be isolated, their subsequent cyclization was found to deliver original hexacyclic derivatives like [1]benzothiopyrano[4,3,2-de]benzothieno[2,3-b]quinoline and [1]benzothiopyrano[4,3,2-de]benzofuro[2,3-b]quinoline of helicoidal nature. Evaluation of their photophys. properties revealed high fluorescence in polar media, indicating potential applications for biol. imaging. These compounds being able to inhibit PIM1 kinase, their putative binding mode was examined through mol. modeling experiments Altogether, these results tend to suggest the discovery of a new family of fluorescent PIM inhibitors and pave the way for their future rational optimization.

Bioorganic Chemistry published new progress about 69626-75-1. 69626-75-1 belongs to benzofurans, auxiliary class Iodide,Benzofuran, name is 2-Iodobenzofuran, and the molecular formula is C8H5IO, HPLC of Formula: 69626-75-1.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Amao, Yutaka published the artcileAn optical sensor with the combination of colorimetric change of α-naphtholphthalein and internal reference luminescent dye for CO₂ in water, Computed Properties of 596-01-0, the publication is Sensors and Actuators, B: Chemical (2005), 107(2), 861-865, database is CAplus.

A new optical CO₂ sensor based on luminescence intensity changes of tetraphenylporphyrin (TPP) due to the absorption change of pH indicator dye (α-naphtholphthalein) with CO₂ is developed and its CO₂ sensing properties in pure H₂O were studied. The observed luminescence intensity from TPP at 650 nm increased with increasing the CO₂ concentration in pure H₂O. The ratio I₁₀₀/I₀, where I₀ and I₁₀₀ represent the detected luminescence intensities from a layer exposed to 100% Ar and 100% CO₂, resp., that the authors takes the sensitivity of the sensor is 430. The response times of the sensing film are 42.6 s for switching from Ar to CO₂, and 88.8 s for switching from CO₂ to Ar in pure H₂O. The signal changes are fully reversible and no hysteresis is observed during the measurements.

Sensors and Actuators, B: Chemical published new progress about 596-01-0. 596-01-0 belongs to benzofurans, auxiliary class Benzofuran,Naphthalene,Alcohol,Ester, name is 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one, and the molecular formula is C28H18O4, Computed Properties of 596-01-0.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Amao, Yutaka published the artcileOptical CO₂ sensor with the combination of colorimetric change of α-naphtholphthalein and internal reference fluorescent porphyrin dye, Computed Properties of 596-01-0, the publication is Sensors and Actuators, B: Chemical (2004), 100(3), 347-351, database is CAplus.

A new optical CO₂ sensor based on the overlay of the CO₂ induced absorbance change of pH indicator dye α-naphtholphthalein with the fluorescence of tetraphenylporphyrin (TPP) was developed. The observed luminescence intensity from TPP at 655 nm increased with increasing the CO₂ concentration The ratio I₁₀₀/I₀ values of the sensing films consisting of α-naphtholphthalein in Et cellulose layer and TPP in polystyrene layer, where I₀ and I₁₀₀ represent the detected luminescence intensities from a layer exposed to 100% nitrogen and 100% CO₂, resp., that the sensitivity of the sensor, are >53.9. The response and recovery times of the sensing films consisting of α-naphtholphthalein in Et cellulose layer and TPP in polystyrene layer were <5 s for switching from nitrogen to CO₂, and for switching from CO₂ to nitrogen. The signal changes were fully reversible and no hysteresis was observed during the measurements. The highly sensitive optical CO₂ sensor based on fluorescence intensity changes of TPP due to the absorption change of α-naphtholphthalein with CO₂ was achieved.

Sensors and Actuators, B: Chemical published new progress about 596-01-0. 596-01-0 belongs to benzofurans, auxiliary class Benzofuran,Naphthalene,Alcohol,Ester, name is 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one, and the molecular formula is C28H18O4, Computed Properties of 596-01-0.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Sichaem, Jirapast published the artcileChemical Constituents of the Leaves of Artocarpus integer, HPLC of Formula: 56317-21-6, the publication is Chemistry of Natural Compounds (2022), 58(3), 538-540, database is CAplus.

During our recent chem. investigation, 11 compounds, epiafzelechin (1) , (+)-epicatechin (2), 3β-hydroxy-7α-methoxy-24β-ethylcholest-5-ene (3) , isobavachalcone (4), kuwanon J (5), moracin M (6), morachalcone A (7) ,apigenin (8) , scopoletin (9), ferulic acid (10), and luteolin (11) were isolated from the leaves of A. integer. Their structures were identified by interpretation of their spectroscopic data and comparison with those reported in the literature. Among these compounds, compounds 2, 6, and 11 exhibited potent antioxidant activity in DPPH radical scavenging with IC50 values of 20.59 ± 0.56, 54.17 ± 1.84, and 26.43 ± 0.17 μg/mL, resp.

Chemistry of Natural Compounds published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C17H18N2O6, HPLC of Formula: 56317-21-6.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem