Heterocyclic Building Block-benzofuran

Comparative study of soluble soybean polysaccharides on bread staling under acidic conditions was written by Hong, Tingting;Wang, Lulu;Xu, Yue;Jin, Yamei;Xu, Dan;Wu, Fengfeng;Xu, Xueming. And the article was included in Food Chemistry in 2023.Electric Literature of C8H8O This article mentions the following:

Effect of soluble soybean polysaccharides (SSPS) and acidic condition on the bread staling of crumb and crust were evaluated in bread characteristics, water migration, starch retrogradation, and flavor. Bread characteristic anal. showed SSPS and acidic conditions significantly improved bread quality during storage, maintaining crumb softness. The staling rate of the synergistic group under SSPS and acidic condition decreased by 49.46% compared to the control group. This retardation was associated with water migration and starch retrogradation. SSPS and acidic conditions restricted the water migration from crumb to crust. A synergy between SSPS and acidification restrained the relative crystallinity and retrogradation enthalpy in bread crumbs and crust during storage. The scores plot and heat map anal. indicated SSPS and acidic condition was facilitated the flavors retention in the crumb and crust after stored 7-days. This study suggested SSPS and acidic conditions might be beneficial for extending bread shelf-life. In the experiment, the researchers used many compounds, for example, 2,3-Dihydrobenzo[b]furan (cas: 496-16-2Electric Literature of C8H8O).

2,3-Dihydrobenzo[b]furan (cas: 496-16-2) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Electric Literature of C8H8O

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Hydrophobic constituents of Arnebia euchroma was written by Ye, Jia;Mu, Qing. And the article was included in Zhongyaocai in 2009.Product Details of 54120-64-8 This article mentions the following:

Massive hydrophobic constituents of Arnebia euchroma were investigated, and similarities and differences of AE and AEZ from different sources were compared. The hydrophobic constituents, AE01-1 and AEZ01-1, were obtained by chromatograph of silica gel with elution of chloroform used in the chloroform extracts of Arnebia euchroma, AE01 and AEZ01. GC-MS was used to identify the main components of the hydrophobic constituents. Eleven and 22 compounds were identified in the hydrophobic constituency, AE01-1 and AEZ01-1, including 5 common compounds that were the main components. AE01-1, the hydrophobic constituents of AE, had 2 naphthoquinones, while AEZ01-1, the hydrophobic constituents of AEZ, had only lipid compounds Compared with AE, AEZ has fewer naphthoquinones with low polarity. In the experiment, the researchers used many compounds, for example, 5-Methylisobenzofuran-1(3H)-one (cas: 54120-64-8Product Details of 54120-64-8).

5-Methylisobenzofuran-1(3H)-one (cas: 54120-64-8) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Product Details of 54120-64-8

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Designing de Novo Small Molecules That Control Heat Shock Protein 70 (Hsp70) and Heat Shock Organizing Protein (HOP) within the Chaperone Protein-Folding Machinery was written by Zaiter, Samantha S.;Huo, Yuantao;Tiew, Fong Y.;Gestwicki, Jason E.;McAlpine, Shelli R.. And the article was included in Journal of Medicinal Chemistry in 2019.Quality Control of H-Arg(Pbf)-OH This article mentions the following:

Protein-protein interactions (PPIs) regulate all signaling pathways for cellular function. Developing mols. that modulate PPIs through the interface of their protein surfaces has been a significant challenge and there has been little success controlling PPIs through standard mol. library screening approaches. PPIs control the cell’s protein-folding machinery, and this machinery relies on a multi-protein complex formed with heat shock protein 70 (Hsp70). Described is the design, synthesis, and biol. evaluation of mols. aimed to regulate the interaction between two proteins that are critical to the protein-folding machinery: heat shock protein 70 (Hsp70) and cochaperone heat shock organizing protein (HOP). We report the first class of compounds that directly regulate these two protein-protein interactions and inhibit protein folding events. In the experiment, the researchers used many compounds, for example, H-Arg(Pbf)-OH (cas: 200115-86-2Quality Control of H-Arg(Pbf)-OH).

H-Arg(Pbf)-OH (cas: 200115-86-2) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.Quality Control of H-Arg(Pbf)-OH

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

MCR-ALS with sample insertion constraint to enhance the sensitivity of surface-enhanced Raman scattering detection was written by Sricharoen, Nontawat;Sukmanee, Thanyada;Pienpinijtham, Prompong;Ekgasit, Sanong;Kitahama, Yasutaka;Ozaki, Yukihiro;Wongravee, Kanet. And the article was included in Analyst (Cambridge, United Kingdom) in 2021.Formula: C10H12O2 This article mentions the following:

The multivariate curve resolution-alternative least squares (MCR-ALS) algorithm was modified with sample insertion constraint to deconvolute the overlapping peaks in SERS spectra. The developed method was evaluated by the spectral data simulated using a Gaussian distribution function to generate two independent peaks corresponding to a capping agent and an analyte. The spectra were generated with different overlapping levels and various intensity ratios of the analyte to the capping agent. By using MCR-ALS with the sample insertion constraint, the peak of the capping agent was completely excluded to obtain a calibration model of the analyte with R² > 0.95 under all conditions. Furthermore, our developed method was later applied to a real SERS measurement to quantify carbofuran (analyte) using the azo-coupling reaction with p-ATP (capping agent) on silver nanoparticles as a SERS substrate. A calibration model of derivative carbofuran phenol was generated with R² = 0.99 and LOD = 28.19 ppm. To assess the performance of the calibration model, the model was used to estimate the concentration of carbofuran in an external validation set. It was found that the RMSE of prediction was only 2.109 with a promising R² = 0.97. In the experiment, the researchers used many compounds, for example, 2,2-Dimethyl-2,3-dihydrobenzofuran-7-ol (cas: 1563-38-8Formula: C10H12O2).

2,2-Dimethyl-2,3-dihydrobenzofuran-7-ol (cas: 1563-38-8) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Formula: C10H12O2

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Environmental screening by capillary gas chromatography combined with mass spectrometry and atomic emission spectroscopy was written by Pedersen-Bjergaard, Stig;Semb, Svein Ingar;Vedde, John;Brevik, Einar Magne;Greibrokk, Tyge. And the article was included in Chemosphere in 1996.Name: Naphtho[2,1-b]benzofuran This article mentions the following:

Capillary gas chromatog. (GC) combined with mass spectrometry (MS) and at. emission spectroscopy (AED) was used for a comprehensive investigation of organic micropollutants in a marine sediment. Most compounds were found and identified by a GC-MS library search. The elemental information from GC-AED was used for confirmation purposes, for analyte characterization in cases where GC-MS identification was impossible, and for screening heteroat. components. In addition, GC-AED was effectively used for the quant. part, where the total amount of GC-amenable material, compound classes, and individual components were determined In the experiment, the researchers used many compounds, for example, Naphtho[2,1-b]benzofuran (cas: 205-39-0Name: Naphtho[2,1-b]benzofuran).

Naphtho[2,1-b]benzofuran (cas: 205-39-0) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Name: Naphtho[2,1-b]benzofuran

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

A UPLC-MS/MS method for in vivo and in vitro pharmacokinetic studies of psoralenoside, isopsoralenoside, psoralen and isopsoralen from Psoralea corylifolia extract was written by Wang, Yue-Fei;Liu, Ya-Nan;Xiong, Wen;Yan, Dong-Mei;Zhu, Yan;Gao, Xiu-Mei;Xu, Yan-Tong;Qi, Ai-Di. And the article was included in Journal of Ethnopharmacology in 2014.Synthetic Route of C17H18O9 This article mentions the following:

The dried fruit of Psoralea corylifolia L. has been used to prevent and treat vitiligo, osteoporosis, arthralgia and asthma in Traditional Chinese Medicine for some 1600 years. Psoralen (P), isopsoralen (IP), psoralenoside (PO) and isopsoralenoside (IPO) are the major coumarins and coumarin-related benzofuran glycosides in Psoraleae Fructus, which have been reported to show estrogen-like activity, osteoblastic proliferation accelerating activity, antitumor effects and antibacterial activity. The first aim of this study is to develop a rapid, sensitive and selective ultra performance liquid chromatog. tandem mass spectrometry (UPLC-MS/MS) approach for simultaneous determination of PO, IPO, P and IP in rat plasma and samples collected from in vitro incubation experiments The second aim is to investigate the pharmacokinetic properties of PO, IPO, P and IP after oral administration of Psoralea corylifolia extract (PCE) to rats. The third aim is to confirm the biotransformation of PO to P or IPO to IP under gastrointestinal conditions.A UPLC-MS/MS method with a C18 column and a mobile phase of methanol-0.1% aqueous formic acid was validated according to the criteria in FDA guidelines about bioanal. method, which was developed to investigate the pharmacokinetic behavior of PO, IPO, P and IP from PCE and the metabolic pathways of PO to P or IPO to IP.The criteria for establishment of a new UPLC-MS/MS method including selectivity, linearity, accuracy, precision, extraction recovery, matrix effect and stability were validated. This method was successfully applied to the quant. determination of PO, IPO, P and IP in biol. samples collected from both in vitro incubations and in vivo rat experiments After oral administration of PCE to rat, pharmacokinetic parameters of these four compounds indicated that in vivo biotransformation may occur between PO and P or IPO and IP. Purified benzofuran glycosides fraction (PBGF), containing only PO and IPO, was orally administered to rats to further confirm the biotransformation of PO to P or IPO to IP under gastrointestinal conditions. An in vitro incubation study elucidated that PO and IPO were metabolized to P and IP by intestinal microflora through de-glucosylation.This paper developed a rapid, sensitive and selective UPLC-MS/MS method for simultaneous determination of PO, IPO, P and IP from PCE in biol. samples, and investigated on their comprehensive in vivo and in vitro pharmacokinetic studies. These obtained results showed that the metabolism by intestinal bacteria plays an important role in pharmacol. effects of orally administered PCE. In the experiment, the researchers used many compounds, for example, (Z)-3-(6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)benzofuran-5-yl)acrylic acid (cas: 905954-17-8Synthetic Route of C17H18O9).

(Z)-3-(6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)benzofuran-5-yl)acrylic acid (cas: 905954-17-8) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.Synthetic Route of C17H18O9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

An efficient synthesis of 4-substituted coumarin derivatives via a palladium-catalyzed Suzuki cross-coupling reaction was written by Rajale, Trideep;Sharma, Shikha;Stroud, Daniel A.;Unruh, Daniel K.;Miaou, Emily;Lai, Kimberly;Birney, David M.. And the article was included in Tetrahedron Letters in 2014.Synthetic Route of C8H5BF3KO This article mentions the following:

An efficient Pd-catalyzed Suzuki cross-coupling reaction of sterically crowded 4-chlorocoumarin derivatives with air- and moisture-stable potassium organotrifluoroborates is developed. This methodol. has been used to generate a series of novel alkyl, aryl, and vinyl substituted coumarin derivatives in good to excellent yields. The twisted conformation of the vinyl groups in the X-ray crystal structures of (2-oxo-4-vinyl-2H-chromen-3-yl)methyl acetate and (2-oxo-4-vinyl-2H-chromen-3-yl)methyl 2,2,2-trichloroacetimidate, along with the atropisomerism of 3-(hydroxymethyl)-4-(2-methoxyphenyl)-2H-chromen-2-one, are evidence of the steric crowding in these adducts. In the experiment, the researchers used many compounds, for example, Potassium benzofuran-2-yltrifluoroborate (cas: 929626-27-7Synthetic Route of C8H5BF3KO).

Potassium benzofuran-2-yltrifluoroborate (cas: 929626-27-7) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Synthetic Route of C8H5BF3KO

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Platinum-on-Carbon-Catalyzed Aqueous Oxidative Lactonization of Diols by Using Molecular Oxygen was written by Takakura, Ryoya;Ban, Kazuho;Sajiki, Hironao;Sawama, Yoshinari. And the article was included in Synlett in 2019.Related Products of 54120-64-8 This article mentions the following:

A lactonization of various diols e.g., I catalyzed by platinum on carbon (Pt/C) in water under an atm. of mol. oxygen was developed. Diols e.g., I were transformed into lactones e.g., II by the present oxidative lactonization method. In the experiment, the researchers used many compounds, for example, 5-Methylisobenzofuran-1(3H)-one (cas: 54120-64-8Related Products of 54120-64-8).

5-Methylisobenzofuran-1(3H)-one (cas: 54120-64-8) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.Related Products of 54120-64-8

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Mono- and dialdehyde of trehalose: new synthons to prepare trehalose bio-conjugates was written by Greco, Valentina;Sciuto, Sebastiano;Rizzarelli, Enrico. And the article was included in Organic & Biomolecular Chemistry in 2021.Category: benzofurans This article mentions the following:

Trehalose, a non-reducing disaccharide of glucose, is a natural bioactive and non-toxic sugar. It is found in many organisms that synthesize it when their cells are exposed to stress conditions. While not produced by mammalian cells, this disaccharide and also some of its derivatives have been shown to have a number of interesting properties that indicate their importance in the treatment of certain human diseases. Differentiating the two glucosyl moieties in the trehalose mol. has often been a synthetic challenge. We report here an easy way to obtain the mono-aldehyde of trehalose, as well as the relevant sym. dialdehyde. The reactivity of the aldehyde functionalities involved in the mol. structure of these synthons allows the easy preparation of the corresponding amino or carboxy derivatives of trehalose, as well the synthesis of some new trehalose conjugates useful for diagnostic or therapeutic purposes. In the experiment, the researchers used many compounds, for example, 5-Amino-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 3326-34-9Category: benzofurans).

5-Amino-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 3326-34-9) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Category: benzofurans

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Novel 2-arylbenzofuran dimers and polyisoprenylated flavanones from Sophora tonkinensis was written by Luo, Guoyong;Yang, Yun;Zhou, Min;Ye, Qi;Liu, Yan;Gu, Jian;Zhang, Guolin;Luo, Yinggang. And the article was included in Fitoterapia in 2014.Related Products of 6807-83-6 This article mentions the following:

Two novel 2-arylbenzofuran dimers, shandougenines A (1) and B (2), and two new polyisoprenylated flavanones 3 (shandougenine C) and 4 (shandougenine D) were isolated from the 95% EtOH extract of Sophora tonkinensis, together with 18 known compounds Their structures were determined on the basis of spectral data interpretation and by comparing the spectral data with that reported previously for known compounds Shandougenine A (1) is a unique dimeric 2-arylbenzofuran with a C-3-C-5”’ bond linkage. Shandougenine B (2) is the first naturally occurring dimeric 2-arylbenzofuran with a novel C-3-C-3” bond linkage. Compound 1 showed moderate DPPH free radical scavenging capacity, whereas 2 has stronger DPPH free radical and ABTS cation radical scavenging capacity than Vc. Compounds 12, 19, and 20 showed parallel DPPH free radical scavenging capacity with Vc. Compounds 1, 3, 4, 19, 20, and 22 have parallel ABTS cation radical scavenging capacity to Vc. Compounds 1, 3, 4, and 18 showed slightly stronger superoxide anion radical scavenging capacity than the known flavanone luteolin. The antioxidant activities of shandougenines A (1) and B (2) indicated that compounds 1 and 2 may represent novel scaffolds for the development of new antioxidants. In the experiment, the researchers used many compounds, for example, (2S,3R,4S,5S,6R)-2-(((6aR,12aR)-6a,12a-Dihydro-6H-[1,3]dioxolo[4′,5′:5,6]benzofuro[3,2-c]chromen-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 6807-83-6Related Products of 6807-83-6).

(2S,3R,4S,5S,6R)-2-(((6aR,12aR)-6a,12a-Dihydro-6H-[1,3]dioxolo[4′,5′:5,6]benzofuro[3,2-c]chromen-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 6807-83-6) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Related Products of 6807-83-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem