Iridium(III)-Catalyzed Asymmetric Site-Selective Carbene C-H Insertion during Late-Stage Transformation was written by Yamakawa, Yuki;Ikuta, Takashi;Hayashi, Hiroki;Hashimoto, Keigo;Fujii, Ryoma;Kawashima, Kyohei;Mori, Seiji;Uchida, Tatsuya;Katsuki, Tsutomu. And the article was included in Journal of Organic Chemistry in 2022.Quality Control of 2,3-Dihydrobenzo[b]furan This article mentions the following:
Here, it was observed that the iridium-salen complex 6 exhibited efficient catalysis in asym. carbene C-H insertion reactions. Under optimized conditions, benzylic, allylic, and propargylic C-H bonds e.g., I were converted to desired C-C bond products e.g., II in an excellent stereoselective manner. Excellent regioselectivity was demonstrated in the reaction using not only simple substrate but also natural products, bearing multiple reaction sites. Moreover, based on the mechanistic studies, the iridium-catalyzed unique C-H insertion reaction involved rate-determining asynchronous concerted processes. In the experiment, the researchers used many compounds, for example, 2,3-Dihydrobenzo[b]furan (cas: 496-16-2Quality Control of 2,3-Dihydrobenzo[b]furan).
2,3-Dihydrobenzo[b]furan (cas: 496-16-2) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Quality Control of 2,3-Dihydrobenzo[b]furan
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem