Hydrophobicity parameters determined by reversed-phase liquid chromatography. VIII. Hydrogen-bond effects of ester and amide groups in heteroaromatic compounds on the relationship between the capacity factor and the octanol-water partition coefficient was written by Yamagami, Chisako;Yokota, Miho;Takao, Narao. And the article was included in Journal of Chromatography A in 1994.Category: benzofurans This article mentions the following:
The logarithms of the capacity factors, log k’, for several heteroaromatic systems (furan, pyrrole, benzofuran, indole, benzene and their alkyl, ester and amide derivatives) were determined on a Capcell Pak C18 column using methanol-buffer (pH 7.4) mobile phases of different compositions These results and the log kw values, derived by a linear extrapolation of the plot of log k’ against the volume fraction of methanol to 0% methanol, were correlated with exptl. log P values by taking into account the hydrogen-acceptor and hydrogen-donor effects. Whereas the hydrogen-donor effect is minimized by using the log kw parameter, the hydrogen-acceptor effect was found to become insignificant in an eluent containing 50% methanol. Isocratic data determined at this eluent composition gave the simplest and best correlation. In the experiment, the researchers used many compounds, for example, Methyl benzofuran-2-carboxylate (cas: 1646-27-1Category: benzofurans).
Methyl benzofuran-2-carboxylate (cas: 1646-27-1) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Category: benzofurans
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem