So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Braden, A.; Roner, M.; Ganter, J.; Nelson, K. researched the compound: Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate( cas:70539-42-3 ).Related Products of 70539-42-3.They published the article 《Transport of biologically active molecules to intracellular environments utilizing a lyzosomally cleavable random block copolymer of polyethylenimine》 about this compound( cas:70539-42-3 ) in Journal of Biomedical Nanotechnology. Keywords: polyethylenimine genetic vector transfection ethylene glycol bis succinimidyl succinate. We’ll tell you more about this compound (cas:70539-42-3).
The use of cationic polymers for the delivery of DNA to mammalian cells has generated significant interest due to the intrinsic properties associated with these delivery vector systems. One particular system utilizing polyethylenimine (PEI) has been rigorously investigated. A major drawback associated with PEI is the cytotoxicity of the vector/delivery system. In an effort to combat this adverse side effect we have synthesized a novel random block copolymer based upon low mol. weight PEI. Here we report the grafting of EGS (ethylene glycol bis(succinimidyl succinate)), to a low mol. weight PEI. Upon cellular transfection, introduction of two carboxylester bonds from the bioconjugation process are cleavable within the lytic pathways of the cell. We confirm the successful grafting of this agent through FTIR and C-13 NMR. Mol. weight determination of the grafted copolymer was performed through HPLC-SEC and light scattering experiments This polymer retains the ability to deliver GFP encoding plasmid DNA to 3T3 fibroblasts. Transfection levels were found to be approx. 90%. Transfection of T7 RNA dependent DNA polymerase was also performed utilizing our copolymer. We find successful activation of a virally introduced RNA transcript.
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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem