Condensation of salicylonitrile with some α-halo carbonyl compounds was written by Trofimov, F. A.;Lelyak, G. F.;Shevchenko, L. I.;Grinev, A. N.. And the article was included in Khimiya Geterotsiklicheskikh Soedinenii in 1974.Application of 54802-10-7 This article mentions the following:
Benzofurans (I; R = H, Br, R1 = OMe, NH2, Ph, Me, R2 = Ac, H) were obtained in 20-84% yields by condensation of a salicylonitrile with XCH2COR1 (X = Cl, Br). Hydrolysis of I (R = H, R1 = OMe, R2 = Ac) by NaOH gave 90% I (R = H, R1 = OH, R2 = Ac) which was decarboxylated by heating in DMF to give 31% II. In the experiment, the researchers used many compounds, for example, 3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7Application of 54802-10-7).
3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.Application of 54802-10-7
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem