4265-16-1, Name is Benzo[b]furan-2-carboxaldehyde, belongs to benzofuran compound, is a common compound. Safety of Benzo[b]furan-2-carboxaldehydeIn an article, once mentioned the new application about 4265-16-1.
Synthesis and Insecticidal Activity of Spinosyns with C9- O -Benzyl Bioisosteres in Place of the 2?,3?,4?-Tri- O -methyl Rhamnose
The spinosyns are fermentation-derived natural products active against a wide range of insect pests. They are structurally complex, consisting of two sugars (forosamine and rhamnose) coupled to a macrocyclic tetracycle. Removal of the rhamnose sugar results in a >100-fold reduction in insecticidal activity. C9-O-benzyl analogues of spinosyn D were synthesized to determine if the 2?,3?,4?-tri-O-methyl rhamnose moiety could be replaced with a simpler, synthetic bioisostere. Insecticidal activity was evaluated against larvae of Spodoptera exigua (beet armyworm) and Helicoverpa zea (corn earworm). Whereas most analogues were far less active than spinosyn D, a few of the C9-O-benzyl analogues, such as 4-CN, 4-Cl, 2-isopropyl, and 3,5-diOMe, were within 3-15 times the activity of spinosyn D for larvae of S. exigua and H. zea. Thus, although not yet quite as effective, synthetic bioisosteres can substitute for the naturally occurring 2?,3?,4?-tri-O-methyl rhamnose moiety.
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Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H979O – PubChem