A derivatisation agent selection guide was written by Tobiszewski, Marek;Namiesnik, Jacek;Pena-Pereira, Francisco. And the article was included in Green Chemistry in 2017.Safety of 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione This article mentions the following:
The study reported herein is aimed at the greenness assessment of 267 derivatization agents that are frequently applied in anal. chem. and related disciplines. Multicriteria decision anal. allowed obtaining three rankings of derivatization agents applied in liquid chromatog., gas chromatog. and chiral anal. The criteria of assessment included the safety information obtained from material safety data sheets and physicochem. and environmental parameters predicted with relevant models. As for some of the agents predicted data were not available, these agents were assessed with a smaller number of criteria, within the ranking of low confidence. The results of the study will help to apply greener derivatization agents, wherever the green chem. principle of avoiding derivatization cannot be fulfilled. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Safety of 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione).
4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Safety of 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem