Reference of 496-41-3, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, and a compound is mentioned, 496-41-3, Benzofuran-2-carboxylic acid, introducing its new discovery.
Imidazolidine and 1,4-diazepane analogs of N-(2-benzofuranyl)methyl- N?-(4-alkoxybenzyl)piperazines were prepared to explore the effect of ring contraction and expansion on sigma receptor affinity and subtype selectivity within a series of cyclic diamines. In vitro receptor binding assays revealed that all cyclic vicinal diamines possessed affinity and selectivity for sigma1 receptors. The imidazolidines possessed nanomolar sigma1 affinities (Ki = 6.45-53.5 nM), and relatively low levels of subtype selectivity (sigma2/sigma1 = 58-237). However, the piperazines and diazepanes achieved picomolar sigma1 interactions, with Ki ranges of 0.05-10.28 and 0.10-0.194 nM, respectively. Moreover, the piperazines and diazepanes showed excellent discrimination over the sigma2 receptor, with sigma1 selectivities of 143-16140 and 220-11542, respectively.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Reference of 496-41-3. In my other articles, you can also check out more blogs about 496-41-3
Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H1909O – PubChem