The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《The effect of 6-azauridine on the contractile responses of the isolated ileum of the guinea pig to drugs and to coaxial stimulation》. Authors are Seferna, I.; Lukomskaya, N.; Kadlec, O.; Janku, I..The article about the compound:Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-idecas:129-18-0,SMILESS:O=C(N(C1=CC=CC=C1)N2C3=CC=CC=C3)[C-](CCCC)C2=O.[Na+]).Reference of Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide. Through the article, more information about this compound (cas:129-18-0) is conveyed.
Small concentrations of 6-azauridine augmented the contractions of the isolated guinea pig ileum to acetylcholine, nicotine, histamine, barium chloride, and coaxial stimulation. High concentrations partially inhibited all the responses. After prolonged contact with high concentrations of 6-azauridine, the antispasmogenic effect persisted long after washing out the compound The acetylcholine output did not change under these conditions. Comparison of the actions of 6-azauridine with those of papaverine is made and the possible mechanisms of action are discussed.
As far as I know, this compound(129-18-0)Reference of Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.
Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem