Baskin, Leonard S.; Yang, Chung S. published an article about the compound: Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate( cas:70539-42-3,SMILESS:O=C(ON1C(CCC1=O)=O)CCC(OCCOC(CCC(ON2C(CCC2=O)=O)=O)=O)=O ).Name: Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:70539-42-3) through the article.
Crosslinking studies were carried out to investigate the structural organization of monooxygenase enzymes. Liver microsomal cytochrome P 450 (P-450) and NADPH-cytochrome P-450 reductase were purified from phenobarbital-treated rats. When purified P-450 or reductase was reacted with 2 mM dimethylsuberimidate for 1 min, the predominant crosslinked species were the dimer and trimer of P-450 and the dimer of the reductase as analyzed by Na dodecyl sulfate-polyacrylamide gel electrophoresis. Crosslinking P-450 with 2 mM di-Me 3,3′-dithiobis(propionimidate) for 1 min gave a gel electrophoresis pattern of monomer through octamer of P-450. Reductase crosslinked under the same conditions gave a monomer through tetramer band pattern. Gel filtration experiments indicated that the purified P-450 existed in protein micelles corresponding to a decamer. The results were attributed to crosslinking within the protein micelle. When a mixture of P-450 and reductase was crosslinked with 2 mM di-Me 3,3′-dithiobis(propionimidate) for 1 min, a mixed dimer of P-450 and reductase was the predominant crosslinked product in addition to the dimers of P-450 and reductase. Similar results were also obtained in crosslinking studies with dithiobis(succinimidyl propionate) and ethylene glycolyl bis(succinimidyl succinate). The addition of dilauroylphosphatidylcholine did not alter significantly the crosslinking pattern. The results provide evidence for the formation of a complex between P-450 and reductase under the exptl. conditions.
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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem