A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 66357-35-5, Name is Ranitidine, molecular formula is C13H22N4O3S. In an article, author is Taha, Muhammad,once mentioned of 66357-35-5, Name: Ranitidine.
Synthesis, in vitro urease inhibitory potential and molecular docking study of benzofuran-based-thiazoldinone analogues
In continuation of our work on enzyme inhibition, the benzofuran-based-thiazoldinone analogues (1-14) were synthesized, characterized by HREI-MS, H-1 and (CNMR)-C-13 and evaluated for urease inhibition. Compounds 1-14 exhibited a varying degree of urease inhibitory activity with IC50 values between 1.2 +/- 0.01 to 23.50 +/- 0.70 mu M when compared with standard drug thiourea having IC50 value 21.40 +/- 0.21 mu M. Compound 1, 3, 5 and 8 showed significant inhibitory effects with IC50 values 1.2 +/- 0.01, 2.20 +/- 0.01, 1.40 +/- 0.01 and 2.90 +/- 0.01 mu M respectively, better than the rest of the series. A structure activity relationship (SAR) of this series has been established based on electronic effects and position of different substituents present on phenyl ring. Molecular docking studies were performed to understand the binding interaction of the compounds.
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Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem