4265-25-2, Name is 2-Methylbenzofuran, belongs to benzofurans compound, is a common compound. Formula: C9H8OIn an article, once mentioned the new application about 4265-25-2.
The establishment of permanent fish cell cultures dates back in the early 1960s and since then more than 283 fish cell lines have been developed. The cells were isolated from a broad range of tissues such as ovary, fin, swim bladder, heart, spleen, liver, eye muscle, vertebrae, brain, skin and especially embryos from different fish species. In contrast to mammals, fish cell lines are derived from normal tissues, with only a few exceptions isolated from epithelioma or hepatoma Cultured fish cells were used for genotoxicity assessment for the first time in 1979,2 when transformed cells derived from a primary culture of embryonic tissue of butterfly splitfin (Ameca splendens) were used for the evaluation of the induction of sister chromatid exchanges (SCEs) by carcinogens/mutagens. Since then, a variety of different fish cell lines have been successfully introduced for the detection of a large variety of genotoxic endpoints. As most fish karyotypes consist of large numbers of small, irregular chromosomes, chromosomal aberrations (CA), which are usually detected in metaphase-blocked cells, are difficult to discern and to interpret in fish cells, thus the analysis is complicated and time-consuming. Therefore, other methods such as micronucleus assay are recommended for the assessment of chromosomal damage instead of SCE and CA in fish cells (Figure 13.1).
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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H22O – PubChem